Results 61 to 70 of about 85,417 (299)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Mutual Trust: Joint Performance of an Operations Strategy Implementation—Securing the Value Chain by Preparedness [PDF]
, 2018 This chapter discusses mutual trust in the daily construction of public safety. The chapter is based on the corresponding author’s article-based dissertation, with work connecting joint research articles to his action research.
Vesa-Jukka Vornanen +7 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
A social institution based on mutuality and trust [PDF]
British Journal of General Practice, 2011 In 1948 when the NHS was born, the challenge of universal coverage was to include everyone, regardless of ability to pay. This remains an important objective, but it is no longer sufficient. Now that health care can improve public health, via the mass delivery of effective care, the test of universal coverage is that health systems should be seen at ...
openaire +2 more sources
Does Morningstar Shine in the Universe of Mutual Funds? A Study on Morningstar Mutual Fund Ratings [PDF]
, 2009 Using data from Morningstar Principia CDs and employing standard methodologies, we examine the extent to which two mutual fund ratings: Morningstar star ratings and Morningstar stewardship grades can predict future fund performance.
NG, Wee Seng
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
A Stitch in Time? Mutual Trust as the EU’s Fix-All in Case C-183/23 Commission v Malta
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2025 10(2), 463-487 | Article | (Table of Contents) 1. Introduction. – 2. The (limited) substance of the judgment in Commission v Malta: what it says about citizenship per se.
Ruairi O'Neill
doaj +1 more source