Results 21 to 30 of about 97 (92)

Applications and limitations of AI tools in enzyme design

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Enzymes catalyze various different chemical reactions often with high efficiency and selectivity compared to synthetic catalysts. Advances in protein engineering over the past decades have allowed researchers to design enzymes, improving their catalytic performance and adapting them for specific or entirely novel chemical reactions.
Rosa Teijeiro‐Juiz, Nina Egeler, Grzegorz Jamróg, Marion Ringel, Thomas Brück, Bruno Di Geronimo, Bernhard Loll   +6 more
wiley   +1 more source

Tetragonal distortion of the multiferroic compound α‐LiFe5O8 from first‐principles calculations

Journal of Applied Crystallography, Volume 59, Issue 4, Page 1307-1318, August 2026.
First‐principles calculations suggest the tetragonal space group P43212 for the multiferroic compound α‐LiFe5O8, with a direct band gap smaller than that in its widely known cubic space group P4332. The tetragonal lattice distortion a > c is explained by relatively strong antiferromagnetic exchange interactions parallel to the c axis and by Fe–O–Fe ...
Yaoshi Cheng, So-Hyun Park
wiley   +1 more source

Mechanistic Insights Into Metal Binding in the Aggregation Pathway of an Immunoglobulin Light Chain Protein

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Cardiac antibody light chain (AL) amyloidosis is characterized by the deposition of light chain (LC) variable domain (VL) protein in the heart. Transition metals such as copper and zinc have been suggested to enhance the toxicity of circulating soluble LCs. We show here how divalent metal ions influence the aggregation behavior of the patient‐derived λ‐
Tejaswini Pradhan, Riddhiman Sarkar, Joshua Leonhard‐Preu, Adrian F. Schnell, Nadine Schwierz, Bernd Reif   +5 more
wiley   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

AlphaFold2‐Guided Cyclic Peptide Stabilizer Design to Target Protein–Protein Interactions

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1356-1370, July 2026.
ABSTRACT The control and modulation of protein–protein interactions (PPIs) is of central importance for the majority of biological processes and most biomedical applications. Stabilization of PPIs, besides inhibition, is of growing pharmaceutical interest.
Niklas Halbwedl, Martin Zacharias
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, Volume 600, Issue 11, Page 1621-1637, June 2026.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

MXene/PEDOT Functional Coatings on Flexible Microelectrode Arrays for Multianalyte In Vivo Neurochemical Sensing and Electrophysiology

Advanced Functional Materials, Volume 36, Issue 46, 8 June 2026.
A MXene/PEDOT coating enables multimodal functionality and dual‐analyte detection of dopamine and serotonin in flexible microelectrode arrays while enhancing electrophysiological recording quality. The anti‐fouling, low‐impedance interface overcomes key limitations of conventional coatings, providing a robust and versatile platform to investigate the ...
Ilaria Gatti, Karamullah Eisawi, Umisha Siwakoti, Greyson Jadwin, Ashmita Sigdel, Michela Chiappalone, Deepak Kumbhare, Michael Naguib, Elisa Castagnola   +8 more
wiley   +1 more source

Information Dense and Industry Scalable Accelerated Formation

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Pulsed formation can reduce lithium‐ion battery formation time by over 50% while maintaining or enhancing performance. Validated on 25 Ah prismatic cells, this industry‐scalable method yields thinner, more homogeneous solid electrolyte interphases (SEIs).
Leon Merker, Markus Blessing, Bojing Zhang, Helge Sören Stein   +3 more
wiley   +1 more source

Audit‐Ready Machine Learning for Short‐Horizon Equity Prediction: A Dual‐Target Benchmark With Fold‐Isolated Preprocessing

Engineering Reports, Volume 8, Issue 6, June 2026.
This study introduces a rigorous, walk‐forward protocol to evaluate next‐day return and volatility‐proxy forecasting across matched model families. By enforcing fold‐isolated preprocessing and causal feature construction on US mega‐caps, the study eLectively mitigates performance inflation.
Abdul Kadar Muhammad Masum, Md. Abul Kalam Azad, Mirza Nadim Saad, Al‐Amain, Mohammad Azam Khan, A. B. M. Yasir Arafat   +5 more
wiley   +1 more source

Response of stock market volatility to COVID-19 announcements and stringency measures: A comparison of developed and emerging markets. [PDF]

Financ Res Lett, 2022
Bakry W, Kavalmthara PJ, Saverimuttu V, Liu Y, Cyril S.   +4 more
europepmc   +1 more source