Results 21 to 30 of about 26,170 (206)

MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. [PDF]

PLoS ONE, 2007
After ligand binding and endocytosis, cell surface receptors can continue to signal from endosomal compartments until sequestered from the cytoplasm. An important mechanism for receptor downregulation in vivo is via the inward budding of receptors into ...
Anjon Audhya, Ian X McLeod, John R Yates, Karen Oegema   +3 more
doaj   +1 more source

Vps27 recruits ESCRT machinery to endosomes during MVB sorting [PDF]

The Journal of Cell Biology, 2003
Down-regulation (degradation) of cell surface proteins within the lysosomal lumen depends on the function of the multivesicular body (MVB) sorting pathway. The function of this pathway requires the class E vacuolar protein sorting (Vps) proteins. Of the class E Vps proteins, both the ESCRT-I complex (composed of the class E proteins Vps23, 28, and 37 ...
Katzmann, David J., Stefan, Christopher J., Babst, Markus, Emr, Scott D.   +3 more
openaire   +2 more sources

Activity of meropenem/vaborbactam against international carbapenem-resistant Escherichia coli isolates in relation to clonal background, resistance genes, resistance to comparators and region

Journal of Global Antimicrobial Resistance, 2021
Objectives: Carbapenem resistance has emerged inEscherichia coli, including sequence type 131 (ST131) and its fluoroquinolone-resistant H30R subclone, the leading cause of extraintestinal E. coli infections globally.
Brian D. Johnston, Paul Thuras, Stephen B. Porter, Mariana Castanheira, James R. Johnson   +4 more
doaj   +1 more source

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]

, 2015
Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T, Futter, CE, Hartley, JA, Hochhauser, D, Sorkin, A, Tomas, A, Vaughan, SO   +6 more
core   +1 more source

Pre-implantation mouse embryos cultured In vitro under different oxygen concentrations show altered ultrastructures [PDF]

, 2020
Assisted Reproductive Technologies routinely utilize different culture media and oxygen (O2) concentrations to culture human embryos. Overall, embryos cultured under physiological O2 tension (5%) have improved development compared to embryos cultured ...
Antonouli, S, Belli, M, Macchiarelli, G, Nottola, Sa, Palmerini, Mg, Rinaudo, P, Ruggeri, E   +6 more
core   +1 more source

Scattering length of the ground state Mg+Mg collision [PDF]

, 2001
We have constructed the X 1SIGMAg+ potential for the collision between two ground state Mg atoms and analyzed the effect of uncertainties in the shape of the potential on scattering properties at ultra-cold temperatures.
B. Liu, C. R. Vidal, C. W. Muhlhausen, C. W. Oates, C. W. Oates, E. A. Curtis, E. Czuchaj, E. Tiesinga, F. Riehle, F. Riehle, F. Ruschewitz, F.-M. Tao, G. Chalasinski, G. D. Purvis, G. H. F. Diercksen, G. Zinner, H. Katori, H. Katori, J. F. Stanton, J. M. Standard, K. C. Li, K. G. Dyall, K. Sengstock, M. Machholm, M. R. Doery, P. Bertoncini, P. Bertoncini, P. J. Hay, P. O. Fedichev, P. S. Julienne, P. S. Julienne, S. G. Porsev, S. Kotochigova, T. Binnewies, T. Ido, Th. Udem, W. C. Stwalley, W. C. Stwalley, W. J. Balfour, W. J. Stevens, W. Klopper   +40 more
core   +3 more sources

ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting [PDF]

Journal of Cell Biology, 2009
Ubiquitin (Ub) sorting receptors facilitate the targeting of ubiquitinated membrane proteins into multivesicular bodies (MVBs). Ub-binding domains (UBDs) have been described in several endosomal sorting complexes required for transport (ESCRT). Using available structural information, we have investigated the role of the multiple UBDs within ESCRTs ...
Shields, S. Brookhart, Oestreich, Andrea J., Winistorfer, Stanley, Nguyen, Doris, Payne, Johanna A., Katzmann, David J., Piper, Robert   +6 more
openaire   +2 more sources

Analytic Error Estimates [PDF]

, 1994
I present an analytic method for estimating the errors in fitting a distribution. A well-known theorem from statistics gives the minimum variance bound (MVB) for the uncertainty in estimating a set of parameters $\l_i$, when a distribution function $F(z;\
Gould, Andrew
core   +3 more sources

Neddylation of Coro1a determines the fate of multivesicular bodies and biogenesis of extracellular vesicles

Journal of Extracellular Vesicles, 2021
Multivesicular bodies (MVBs) fuse with not only the plasma membranes to release extracellular vesicles (EVs) but also lysosomes for degradation. Rab7 participates in the lysosomal targeting of MVBs.
Xuefeng Fei, Zhijie Li, Diya Yang, Xianghui Kong, Xinliang Lu, Yingying Shen, Xu Li, Shaofang Xie, Jiaoli Wang, Yongchao Zhao, Yi Sun, Jing Zhang, Zhaoming Ye, Jianli Wang, Zhijian Cai   +14 more
doaj   +1 more source

Synergistic Meropenem/Vaborbactam Plus Fosfomycin Treatment of KPC Producing K. pneumoniae Septic Thrombosis Unresponsive to Ceftazidime/Avibactam: From the Bench to the Bedside

Antibiotics, 2021
Gram-negative bacilli septic thrombosis (GNB-ST) represents a subtle and often misleading condition, potentially fatal if not recognized early and requiring prolonged antimicrobial therapy and anticoagulation.
Alessandra Oliva, Ambrogio Curtolo, Lorenzo Volpicelli, Francesco Cogliati Dezza, Massimiliano De Angelis, Sara Cairoli, Donatella Dell’Utri, Bianca Maria Goffredo, Giammarco Raponi, Mario Venditti   +9 more
doaj   +1 more source