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The multivesicular body (MVB), a cluster of vesicles surrounded by a limiting membrane, is a ubiquitous but poorly understood structure in eukaryotic cells. On page 53,Kleijmeer et al. present the first evidence that the MVB can be used as a temporary storage depot for membranes and membrane proteins, which can then be deployed rapidly to the surface ...
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No ESCRT to the Melanosome: MVB Sorting without Ubiquitin [PDF]
Multivesicular bodies (MVBs) are critical for a variety of cellular functions ranging from lysosomal degradation to the budding of HIV. To date, delivery into MVBs has been dependent on the ESCRT machinery. However, analysis of a melanosomal protein has uncovered an alternative pathway for MVB sorting.
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Weighted Co-SVM for Image Retrieval with MVB Strategy [PDF]
In relevance feedback, active learning is often used to alleviate the burden of labeling by selecting only the most informative data. Traditional data selection strategies often choose the data closest to the current classification boundary to label, which are in fact not informative enough.
Xiaoyu Zhang +3 more
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Fungal diseases represent a significant threat to global agriculture, leading to substantial crop losses and endangering food security worldwide. Conventional chemical fungicides, while effective, are increasingly criticized for their detrimental ...
José Sebastian Dávila Costa +1 more
doaj +1 more source
Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death.
Ron Benyair +16 more
doaj +1 more source
Radiation of an electric charge in the field of a magnetic monopole [PDF]
We consider the radiation of photons from quarks scattering on color-magnetic monopoles in the Quark-Gluon Plasma. We consider a temperature regime $T\gsim2T_c$, where monopoles can be considered as static, rare objects embedded into matter consisting ...
B. Berestetskii +8 more
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Masses of vector bosons in two-color dense QCD based on the hidden local symmetry
We construct a low energy effective Lagrangian for the two-color QCD including the "vector" bosons (mesons with J^P=1^- and diquark baryons with J^P=1^+) in addition to the pseudo Nambu-Goldstone bosons with a degenerate mass M_\pi (mesons with J^P=0 ...
Harada, Masayasu +2 more
core +1 more source
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
CHARACTERIZATION OF THE UBIQUITIN LIGASE, UBE4B, IN ENDOCYTIC TRAFFICKING [PDF]
Endocytosis is a process by which cells internalize membrane proteins to remove them from the plasma membrane, allowing cells to regulate the cell surface expression of transmembrane proteins.
Sirisaengtaksin, Natalie +1 more
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Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells [PDF]
microRNAs are short regulatory RNAs in metazoan cells. Regulation of miRNA activity and abundance is evident in human cells where availability of target messages can influence miRNA biogenesis by augmenting the Dicer1-dependent processing of precursors ...
Barman, Bahnisikha +4 more
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