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The basic abnormality in myasthenia gravis (MG) is a reduction in acetylcholine receptors (AChRs) at neuromuscular junctions due to the effects of autoantibodies that are directed against the AChRs in most patients, or against neighboring proteins involved in the clustering of AChRs (MuSK, LRP-4, or agrin).
openaire +5 more sources
Relationship between hearing function and myasthenia gravis: a contemporary review [PDF]
There is increasing evidence of a connection between hearing function and myasthenia gravis (MG). Studies of the pathophysiological basis of this relationship suggest that acetylcholine receptors (AChRs) on outer hair cells (OHCs) play a central role. In
ALTISSIMI, Giancarlo +5 more
core +1 more source
Myasthenia gravis is an autoimmune disorder mainly caused by antibodies to the muscle acetylcholine receptors (AChRs) at the neuromuscular junction. Loss of these receptors leads to a defect in neuromuscular transmission with muscle weakness and fatigue.
Vincent, A, Palace, J, Hilton-Jones, D
openaire +2 more sources
Background Observational studies have demonstrated an association between gut microbiota and myasthenia gravis; however, the causal relationship between the two still lacks clarity.
Tengfei Su +5 more
doaj +1 more source
Audio-vestibular symptoms in systemic autoimmune diseases [PDF]
Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss
Adelchi, Croce +7 more
core +1 more source
Autoimmunity and Immunodeficiency Coexisting in the Same Patient [PDF]
Myasthenia gravis is a well-known autoimmune disorder. Very few cases in literature showed association of myasthenia gravis, thymoma, and oral candidiasis. Here, we present a case of myasthenia gravis with thymoma, significant weight loss, extensive oral
Mugundhan Krishnan +6 more
doaj +1 more source
Pyridostigmine in pediatric Intestinal pseudo-obstruction. case report of a 2-year old girl and literature review [PDF]
Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes.
Caló, Girolamo +8 more
core +2 more sources
Prognosis of Ocular Myasthenia Gravis: Retrospective Multicenter Analysis [PDF]
PURPOSE: To calculate the rate and timing of conversion from ocular myasthenia gravis to generalized myasthenia gravis. DESIGN: Retrospective multicenter analysis. SUBJECTS: Patients included in the study were diagnosed with ocular myasthenia gravis
Abusamra, K +4 more
core +1 more source
Docetaxel/cisplatin therapy in myasthenia gravis with hypertension/diabetes
Therapeutic options for thymoma-associated myasthenia gravis (MG) patients complicated with hypertension and/or diabetes post thymectomy are often conventional steroids. As the prevalence of diabetes and hypertension globally increases, other therapeutic
Qi Guoyan +4 more
doaj +1 more source
T-lymphocyte-rich thymoma and myasthenia gravis in a Siberian tiger (Panthera tigris altaica) [PDF]
A 10-year-old captive male Siberian tiger (Panthera tigris altaica) presented with acute onset collapse, vomiting and dyspnoea, preceded by a 6-month period of progressive muscle wasting.
A. Routh +31 more
core +1 more source

