Results 11 to 20 of about 50,819 (268)
Orphanet Journal of Rare Diseases, 2007 Myasthenia gravis (MG) is a rare, autoimmune neuromuscular junction disorder. Contemporary prevalence rates approach 1/5,000. MG presents with painless, fluctuating, fatigable weakness involving specific muscle groups. Ocular weakness with asymmetric ptosis and binocular diplopia is the most typical initial presentation, while early or isolated ...
Juel, Vern C, Massey, Janice M
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Der Nervenarzt, 2019 ZusammenfassungDie Myasthenia gravis (MG) beruht auf einer durch Autoantikörper (Ak) gegen Acetylcholinrezeptoren (AChR) bzw. andere Strukturproteine der neuromuskulären Endplatte verursachten neuromuskulären Überleitungsstörung mit vorzeitiger Erschöpfbarkeit und teils manifesten Paresen einschließlich der bulbären und okulären Muskulatur. Während die
Wolfgang, Müllges, Guido, Stoll
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Journal of Cardiothoracic Surgery, 2020 Background Despite the burgeoning literature describing preoperative and postoperative risks of a myasthenic crisis after thymectomy (MCAT) in patients with myasthenia gravis, substantial differences exist in the risk factors identified by previous ...
Chaoying Liu +4 more
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BMJ, 2012 Myasthenia gravis (MG) is the most common disorder of the neuromuscular junction (NMJ), with an estimated prevalence between 25 and 142 per million. It characteristically presents with fatigable weakness, often initially involving the ocular muscles and manifesting as intermittent ptosis and diplopia.
Jennifer, Spillane +2 more
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Neurology and Therapy, 2023 Introduction Myasthenia gravis (MG) is a devastating acquired autoimmune disease that can seriously affect the patient’s quality of life. It is also a common complication of thymoma.
Hongxia Yang +5 more
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BMC Medicine, 2021 Background Myasthenia gravis (MG) is an acquired immune-mediated disorder of the neuromuscular junction that causes fluctuating skeletal muscle weakness and fatigue. Pediatric MG and adult MG have many different characteristics, and current MG diagnostic
Peng Liu +10 more
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Myasthenia Gravis and Thymoma. [PDF]
Muscle NerveABSTRACT Thymoma is the most common tumor of the anterior mediastinum. Approximately 20%–30% of patients with a thymoma develop myasthenia gravis (MG), and an additional one third may possess positive acetylcholine receptor (AChR) antibodies without MG.
Claytor B +5 more
europepmc +2 more sources
Antibodies to acetylcholine receptor in parous women with myasthenia: evidence for immunization by fetal antigen [PDF]
, 2002 The weakness in myasthenia gravis (MG) is mediated by autoantibodies against adult muscle acetylcholine receptors (AChR) at the neuromuscular junction; most of these antibodies also bind to fetal AChR, which is present in the thymus.
Wilcox, Nick +13 more
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New England Journal of Medicine, 1978 The basic abnormality in myasthenia gravis (MG) is a reduction in acetylcholine receptors (AChRs) at neuromuscular junctions due to the effects of autoantibodies that are directed against the AChRs in most patients, or against neighboring proteins involved in the clustering of AChRs (MuSK, LRP-4, or agrin).
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Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS [PDF]
, 2012 Myasthenia Gravis (MG) patients suffer from chronic fatigue of skeletal muscles, even after initiation of proper immunosuppressive medication. Since the localization of neuronal nitric oxide synthase (nNOS) at the muscle membrane is important for ...
Meinen, Sarina +7 more
core +2 more sources