Results 71 to 80 of about 50,819 (268)

Tyrosine phosphatase SHP2 accelerated progression of thymic epithelial tumors via promoting PI3K/ERK/CREB/SP1 induced HIF1α and EGFR expression

European Journal of Medical Research
Objective To investigate the impact of SHP2 on thymic epithelial tumors (TETs) and its underlying mechanisms. Methods Bioinformatic analysis was performed to identify key pathways in TETs.
Congya Yan, Shuai Zhao, Guoyan Qi
doaj   +1 more source

Amifampridine phosphate in the treatment of muscle-specific kinase myasthenia gravis: a phase IIb, randomized, double-blind, placebo-controlled, double crossover study

SAGE Open Medicine, 2018
Objective: The aim of this study is to determine the safety and the efficacy of amifampridine phosphate in muscle-specific kinase antibody-positive myasthenia gravis, in a 1:1 randomized, double-blind, placebo-controlled, switchback, double crossover ...
Silvia Bonanno, Maria Barbara Pasanisi, Rita Frangiamore, Lorenzo Maggi, Carlo Antozzi, Francesca Andreetta, Angela Campanella, Greta Brenna, Lorenzo Cottini, Renato Mantegazza   +9 more
doaj   +1 more source

Early onset bilateral juvenile myasthenia gravis masquerading as simple congenital ptosis

, 2017
Myasthenia gravis is an autoimmune disorder affecting the neuromuscular junction. Ocular myasthenia gravis presents as ptosis with extraocular motility restriction and is prone to be misdiagnosed as third nerve palsy or congenital or aponeurotic ptosis ...
Alam, MS, Devi Nivean, P, Devi Nivean, Pratheeba, Alam, Md. Shahid   +3 more
core   +1 more source

A Myasthenia Gravis Case Diagnosed Simultaneously with Diabetic Ketoacidosis [PDF]

, 2019
Juvenile myasthenia gravis (JMG) is an autoimmune disease caused by antibodies affecting the postsynaptic membrane at the neuromuscular junction. The association of JMG with Type I diabetes mellitus (DM), another autoimmune disease, is very rare and the ...
Zehra Aycan, Gülin Karacan Küçükali, Şakire Başer, Şenay Savaş Erdeve, Mehpare Özkan   +4 more
core   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Serum fibrinogen is not elevated in patients with myasthenia gravis

Scientific Reports
Myasthenia gravis (MG) is an autoimmune, autoantibody-mediated disease characterized by fatigable weakness of skeletal muscles. MG is a heterogeneous disease that currently lacks a robust biomarker for diagnosing all subtypes.
Taylor A. Bauman, Sean M. Lee, Vern C. Juel, Yingkai Li, Karli Gilbert, Jiaxin Chen, Henry J. Kaminski, Linda L. Kusner, MGNet Investigators   +8 more
doaj   +1 more source

Epidemiological evidence for a hereditary contribution to myasthenia gravis: a retrospective cohort study of patients from North America

BMJ Open, 2020
Objectives To approximate the rate of familial myasthenia gravis and the coexistence of other autoimmune disorders in the patients and their families.Design Retrospective cohort study.Setting Clinics across North America.Participants The study included ...
Joel Oger, Joshua D Green, Bryan J Traynor, Richard J Barohn, Michael Benatar, Emanuela Bartoccion, Derrick Blackmore, Vinay Chaudhry, Manisha Chopra, Andrea Corse, Mazen M Dimachkie, Amelia Evoli, Julaine Florence, Miriam Freimer, James F Howard, Theresa Jiwa, Henry J Kaminski, John T Kissel, Wilma J Koopman, Bernadette Lipscomb, Michelanglo Maestri, Mariapaola Marino, Janice M Massey, April McVey, Michelle M Mezei, Srikanth Muppidi, Michael W Nicolle, Robert M Pascuzzi, Mamatha Pasnoor, Alan Pestronk, Carlo Provenzano, Roberta Ricciardi, David P Richman, Julie Rowin, Donald B Sanders, Zaeem Siddiqi, Aimee Soloway, Gil I Wolfe, Charlie Wulf, Daniel B Drachman   +39 more
doaj   +1 more source

Muscle-Specific Tyrosine Kinase-Associated Myasthenia Gravis: A Neuromuscular Surprise

Case Reports in Neurological Medicine, 2021
Myasthenia gravis is a neuromuscular autoimmune disease that results in skeletal muscle weakness that worsens after periods of activity and improves after rest.
Hassam Ali, Rahul Pamarthy, Nayab Ahsan, null WashmaAwan, Shiza Sarfraz   +4 more
doaj   +1 more source

Refractory myasthenia gravis – clinical profile, comorbidities and response to rituximab

, 2016
Introduction: Myasthenia gravis (MG) is an antibody mediated autoimmune neuromuscular disorder characterized by fatigable muscle weakness. A proportion of myasthenia gravis patients are classified as refractory due to non responsiveness to conventional ...
Gummadi, S, Burra, HK, Sodalagunta, MB, Settikere Nataraju, Aravinda, Gummadi, Siddharth, Sudulagunta, SR, Burra, Hemanth Kumar, Sepehrar, M, Sathyanarayana, Deepak, Sudulagunta, Sreenivasa Rao, Bangalore Raja, Shiva Kumar, Sepehrar, Mona, Sodalagunta, Mahesh Babu, Settikere Nataraju, A, Sathyanarayana, D, Bangalore Raja, SK   +15 more
core   +1 more source

Sublingual Zolpidem for MRI in Claustrophobic Patients: A Prospective, Non‐Randomized Noninferiority Study

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Claustrophobia during MRI may lead to examination interruption, motion artifacts, prolonged acquisition time, and reduced diagnostic quality, frequently requiring intravenous sedation to ensure successful examination completion and adequate image acquisition.
Beatriz Birelli do Nascimento, Fernando de Sá Del Fiol, Marcus Vinicius Birelli do Nascimento, Lucas Bueno de Oliveira, Samanta Aparecida Alves, Lucas do Nascimento Bernardes   +5 more
wiley   +1 more source