Results 81 to 90 of about 50,819 (268)

Illness perception characteristics and influencing factors in adult patients with myasthenia gravis in China

Brain and Behavior, 2022
Objective We aimed to examine the illness perception characteristics of patients with myasthenia gravis and analyze the associated factors. Methods A general information questionnaire, Illness Perception Questionnaire, and Simplified Coping Style ...
Le Xu, Xia Wang, Yafeng Cui, Yanghua Tian, Nong Zhou, Juanjuan Zhang, Hiaxia Ji, Xiumei Cheng, Qin Zhang, Qingfeng Li, Panpan Hu, Long Zhang   +11 more
doaj   +1 more source

Bilateral Ophthalmoplegia After Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
The role of immune checkpoint inhibition (ICI) therapy in the treatment of head and neck squamous cell carcinoma (HNSCC) is expanding with increased utilization of neoadjuvant and adjuvant pembrolizumab in the setting of locally advanced disease. This report describes the presentation and management of the first known case of pembrolizumab‐induced ...
Leonard E. Estephan, Peter Jacoby, David M. Cognetti, Steven A. Manobianco   +3 more
wiley   +1 more source

Fatigue in Myasthenia Gravis: Recent Advances and Emerging Concepts

Muscle &Nerve, EarlyView.
ABSTRACT Fatigue is a common, often disabling symptom in myasthenia gravis (MG), distinct from muscle fatigability, and strongly associated with reduced quality of life. This narrative review examines current evidence on fatigue in MG, its patient impact, and future research directions. Earlier studies, mostly small and heterogeneous, reported a highly
Yvonne J. M. Campman, Martijn R. Tannemaat, Annabel M. Ruiter, Sarah Hoffmann   +3 more
wiley   +1 more source

Myasthenia gravis as one of paraneoplastic neurological syndromes associated with small cell lung cancer. Case report

Neurologijos seminarai, 2018
Myasthenia gravis associated with extrathymic malignancies is a rarely diagnosed pathology in clinical practice. We report a case of myasthenia gravis-like syndrome associated with small cell lung cancer.
R. Bunevičiūtė , R. Masaitienė , A. Klimašauskienė   +2 more
doaj   +1 more source

Presynaptic Congenital Myasthenic Syndromes

Muscle &Nerve, EarlyView.
ABSTRACT Presynaptic congenital myasthenic syndromes (CMS) encompass a large number of rare neurologic disorders caused by impaired release of acetylcholine (ACh) from motor nerve terminals. There are two main groups of presynaptic CMS: one in which the amount of ACh in synaptic vesicles (SV) is diminished and another in which the mechanism of synaptic
Ricardo A. Maselli
wiley   +1 more source

Proteomic and machine learning analysis predicts treatment response signatures in Myasthenia Gravis

Journal of Translational Medicine
Background Myasthenia gravis (MG) is a prototypical antibody-mediated autoimmune disease with variable treatment responses with a need for biomarkers to guide therapeutic decision making.
Karli Gilbert, Amrita K. Cheema, Henry J. Kaminski, Linda L. Kusner   +3 more
doaj   +1 more source

Outcomes after major surgery in patients with myasthenia gravis: A nationwide matched cohort study.

PLoS ONE, 2017
ObjectiveTo validate the comprehensive features of adverse outcomes after surgery for patients with myasthenia gravis.MethodsUsing reimbursement claims from Taiwan's National Health Insurance Research Database, we analyzed 2290 patients who received ...
Yi-Wen Chang, Yi-Chun Chou, Chun-Chieh Yeh, Chaur-Jong Hu, Chih-Jen Hung, Chao-Shun Lin, Ta-Liang Chen, Chien-Chang Liao   +7 more
doaj   +1 more source

The Differing Phenotypes of the Three Most Common Postsynaptic Congenital Myasthenic Syndromes Governed by Their Underlying Molecular Pathogenic Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT The congenital myasthenic syndromes are rare disorders of impaired signal transmission at the neuromuscular junction. Despite next generation sequencing facilitating the identification of variants in myasthenic‐associated genes, these variants are frequently of unknown significance and the clinical diagnosis can be delayed.
David Beeson
wiley   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Exploring the depths of IgG4: insights into autoimmunity and novel treatments

Frontiers in Immunology
IgG4 subclass antibodies represent the rarest subclass of IgG antibodies, comprising only 3-5% of antibodies circulating in the bloodstream. These antibodies possess unique structural features, notably their ability to undergo a process known as fragment-
Selen Ünlü, Selen Ünlü, Blanca G. Sánchez Navarro, Elif Cakan, Daniel Berchtold, Rafael Meleka Hanna, Secil Vural, Secil Vural, Atay Vural, Atay Vural, Andreas Meisel, Miriam L. Fichtner, Miriam L. Fichtner   +12 more
doaj   +1 more source