Results 1 to 10 of about 1,344,051 (191)

Case report: Successful perioperative intervention with efgartigimod in a patient in myasthenic crisis [PDF]

Frontiers in Immunology
IntroductionThis case describes successful response to efgartigimod in the treatment of myasthenic crisis secondary to paraneoplastic disease, and in the perioperative setting.MethodsAn elderly female presented with speech difficulties, cessation of ...
Shahar Shelly
exaly   +4 more sources

Efgartigimod as Rescue Medication in a Patient with Therapy-Refractory Myasthenic Crisis [PDF]

Case Reports in Neurological Medicine
Myasthenic crises (MC) are potentially life-threatening acute exacerbations of myasthenia gravis (MG) characterized by profound muscle weakness, bulbar symptoms, and potential for respiratory failure.
Omar Alhaj Omar, Norma J. Diel, Stefan T. Gerner, Anna Mück, Hagen B. Huttner, Heidrun H. Krämer-Best   +5 more
doaj   +4 more sources

Case report: Recovery from refractory myasthenic crisis to minimal symptom expression after add-on treatment with efgartigimod

Frontiers in Neurology
Myasthenic crisis, a life-threatening exacerbation of myasthenia gravis, is a significant clinical challenge, particularly when refractory to standard therapies.
Ryuta Kinno, Shinichi Ohashi
exaly   +3 more sources

Case Report: Early rehabilitation initiated in the intensive care unit for myasthenic crisis [PDF]

Frontiers in Rehabilitation Sciences
Myasthenia gravis is an autoimmune disorder of the neuromuscular junction characterized by fatigable muscle weakness. Myasthenic crisis is a life-threatening condition characterized by acute respiratory failure resulting from severe weakness of the ...
Akiyuki Okamoto, Yusuke Sasaki, Yuto Mizutani, Yoshiaki Nakayama, Shoko Yorozu, Kohei Hori, Ken Kouda, Ken Kouda   +7 more
doaj   +2 more sources

Case Report: Zilucoplan in refractory myasthenic crisis and its prodromal stages: a novel therapeutic perspective [PDF]

Frontiers in Neuroscience
Myasthenic crisis (MC) represents life-threatening respiratory failure in myasthenia gravis (MG), while impending myasthenic crisis (iMC) denotes rapidly worsening weakness threatening ventilation however the condition is reversible with timely ...
Liliana Bevilacqua, Carmen Erra, Dario Ricciardi, Francesco Tuccillo, Francesco Habetswallner, Maria Teresa Pellecchia, Maria Teresa Pellecchia, Paolo Barone, Paolo Barone, Claudia Vinciguerra   +9 more
doaj   +2 more sources

Efgartigimod combined with steroids as a fast-acting therapy for myasthenic crisis: a case report [PDF]

BMC Neurology
Background Generalized myasthenia gravis (gMG) can be managed with acetylcholinesterase inhibitors (AChEis; e.g., pyridostigmine), corticosteroids, other immunosuppressive drugs (e.g., tacrolimus), and their combinations. Intravenous immunoglobulin (IVIg)
Hiroya Ohara, Naoya Kikutsuji, Naohiko Iguchi, Masako Kinoshita   +3 more
doaj   +2 more sources

Weaning from mechanical ventilation during myasthenic crisis, a monocentric retrospective study [PDF]

Scientific Reports
Mechanical ventilation in myasthenic crisis is not standardized and is at high risk of failure. We investigated liberation from mechanical ventilation during myasthenic crisis using a prolonged spontaneous breathing trials (SBT) and sequential pulmonary ...
Aurélien Mazeraud, Sivanthiny Sivanandamoorthy, Rossella Mancusi, Bernard Clair, Diane Friedman, Fouad Fadel, Virginie Maxime, Camille Legouy, David Orlikowski, Tarek Sharshar, Nicholas Heming, Djillali Annane   +11 more
doaj   +2 more sources

Efficacy and safety of efgartigimod in the treatment of impending myasthenic crisis [PDF]

Frontiers in Immunology
ObjectiveTo compare the short-term efficacy and safety of efgartigimod versus intravenous immunoglobulin (IVIg) in patients with impending myasthenic crisis (IMC).MethodsThis single-center, randomized, open-label, prospective comparative cohort study ...
Ning Li, Yinghui Zhang, Lu Liu, Yanzi Jin, Li Zhao, Shuhui Zhu, Yating Li, Boya Ma, Jiahui Peng, Juan Yang, Qian Li, Xiao Yang   +11 more
doaj   +2 more sources

Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study [PDF]

Neurotherapeutics
Early intervention in impending myasthenic crisis (IMC) is critical to avert life-threatening progression. This study compared the clinical effectiveness and safety of the novel FcRn antagonist efgartigimod versus intravenous immunoglobulin (IVIg) in IMC
Rongjing Guo, Chao Sun, Xiaoxi Huang, Sijia Hao, Qingqing Wang, Zhe Ruan, Ting Gao, Yonglan Tang, Xiangqi Cao, Yu Liu, Zhuyi Li, Ting Chang   +11 more
doaj   +2 more sources

Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis [PDF]

Annals of Intensive Care
Background: Myasthenic crisis often requires prolonged mechanical ventilation and complex weaning, yet data remain scarce. The objective of this study was to describe the weaning characteristics in patients with myasthenic crisis using the WEAN Safe ...
Clémence Marois, Arthur Combes, Meriem Bouguerra, Alexandra Grinea, Lucas Di Meglio, Thomas Rambaud, Loïc Le Guennec, Francis Bolgert, Benjamin Rohaut, Sophie Demeret, Nicolas Weiss   +10 more
doaj   +2 more sources