Results 11 to 20 of about 2,700 (156)

Efgartigimod as Rescue Medication in a Patient with Therapy-Refractory Myasthenic Crisis [PDF]

Case Reports in Neurological Medicine
Myasthenic crises (MC) are potentially life-threatening acute exacerbations of myasthenia gravis (MG) characterized by profound muscle weakness, bulbar symptoms, and potential for respiratory failure.
Omar Alhaj Omar, Norma J. Diel, Stefan T. Gerner, Anna Mück, Hagen B. Huttner, Heidrun H. Krämer-Best   +5 more
doaj   +2 more sources

Efficacy and safety of efgartigimod in the treatment of impending myasthenic crisis [PDF]

Frontiers in Immunology
ObjectiveTo compare the short-term efficacy and safety of efgartigimod versus intravenous immunoglobulin (IVIg) in patients with impending myasthenic crisis (IMC).MethodsThis single-center, randomized, open-label, prospective comparative cohort study ...
Ning Li, Yinghui Zhang, Lu Liu, Yanzi Jin, Li Zhao, Shuhui Zhu, Yating Li, Boya Ma, Jiahui Peng, Juan Yang, Qian Li, Xiao Yang   +11 more
doaj   +2 more sources

Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study [PDF]

Neurotherapeutics
Early intervention in impending myasthenic crisis (IMC) is critical to avert life-threatening progression. This study compared the clinical effectiveness and safety of the novel FcRn antagonist efgartigimod versus intravenous immunoglobulin (IVIg) in IMC
Rongjing Guo, Chao Sun, Xiaoxi Huang, Sijia Hao, Qingqing Wang, Zhe Ruan, Ting Gao, Yonglan Tang, Xiangqi Cao, Yu Liu, Zhuyi Li, Ting Chang   +11 more
doaj   +2 more sources

Analysis of events from sudden isolated dysarthria to diagnosis of myasthenic crisis: myasthenia gravis mimicking acute lacunar stroke—a case report [PDF]

Journal of Medical Case Reports
Background Myasthenic crisis (MC) is a life-threatening complication of myasthenia gravis (MG), necessitating ventilation. Achieving a safe and timely diagnosis of myasthenic crisis with atypical, isolated presentation is a considerable challenge ...
Simona Petkovic Miletic, Sheikh Ruksana Binte Ahmed   +1 more
doaj   +2 more sources

Weaning from mechanical ventilation in myasthenic crisis according to WEAN safe: most patients experience intermediate or prolonged weaning with no differences between early and late-onset compared to very-late onset myasthenia Gravis [PDF]

Annals of Intensive Care
Background: Myasthenic crisis often requires prolonged mechanical ventilation and complex weaning, yet data remain scarce. The objective of this study was to describe the weaning characteristics in patients with myasthenic crisis using the WEAN Safe ...
Clémence Marois, Arthur Combes, Meriem Bouguerra, Alexandra Grinea, Lucas Di Meglio, Thomas Rambaud, Loïc Le Guennec, Francis Bolgert, Benjamin Rohaut, Sophie Demeret, Nicolas Weiss   +10 more
doaj   +2 more sources

Eculizumab as Additional Rescue Therapy in Myasthenic Crisis [PDF]

Muscles
Eculizumab is a monoclonal antibody blocking the terminal complement protein C5. As demonstrated in the phase III randomized, placebo-controlled, REGAIN clinical trial, eculizumab is efficacious in acetylcholine receptor antibody (AChR-Ab)-positive ...
Francesco Crescenzo, Mattia Zanoni, Laura Ferigo, Francesca Rossi, Matteo Grecò, Angelica Lupato, Alessandra Danese, Domenico Ajena, Michelangelo Turazzini   +8 more
doaj   +2 more sources

First line treatment with subcutaneous efgartigimod in impending myasthenic crisis: a case report [PDF]

Therapeutic Advances in Neurological Disorders
In acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG), neonatal Fc-receptor (FcRn) inhibition has broadened the therapeutic spectrum. Myasthenic crisis (MC), heralded by an impending myasthenic crisis (iMC), is a critical
Isabelle Kwiedor, Martina Menacher, Monika Ellßel, Markus Naumann, Antonios Bayas   +4 more
doaj   +2 more sources

Thymectomy immediately after myasthenic crisis [PDF]

Vojnosanitetski Pregled, 2021
Introduction. Myasthenic crisis ( MC) refers to rapid progression of myasthenic weakness accompanied by ventilatory and bulbar dysfunction. Since there is no single standard accepted in the treatment of every patient in myasthenic crisis, we report our ...
Martić Vesna, Marić Nebojša, Đorđević Dragan   +2 more
doaj   +1 more source

Takotsubo syndrome and myasthenic crisis after radiocontrast media-induced anaphylaxis: a case report [PDF]

Journal of Neurocritical Care, 2022
Background Takotsubo syndrome and myasthenic crisis can be triggered by physical stress. We present the case of a woman who developed Takotsubo syndrome and myasthenic crisis following radiocontrast media-induced anaphylaxis.
Jeong Hee Cho, Hyeongsoo Kim, Jungyon Yum   +2 more
doaj   +1 more source

COVID-19 patients in myasthenic crisis managed successfully with noninvasive positive pressure ventilation: a case series.

Critical Care Innovations, 2021
The management of respiratory failure during the present pandemic has been a challenging issue for the intensivists. There have been few case series and case reports on myasthenic crisis precipitated by severe acute respiratory syndrome coronavirus-2 ...
Mohd Mustahsin, Sanjay Choubey, Varun Malhotra   +2 more
doaj   +1 more source