Results 11 to 20 of about 4,258 (204)

Efgartigimod as Rescue Medication in a Patient with Therapy-Refractory Myasthenic Crisis [PDF]

Case Reports in Neurological Medicine
Myasthenic crises (MC) are potentially life-threatening acute exacerbations of myasthenia gravis (MG) characterized by profound muscle weakness, bulbar symptoms, and potential for respiratory failure.
Omar Alhaj Omar, Norma J. Diel, Stefan T. Gerner, Anna Mück, Hagen B. Huttner, Heidrun H. Krämer-Best   +5 more
doaj   +2 more sources

Efficacy and safety of efgartigimod versus intravenous immunoglobulin in early intervention of acetylcholine receptor antibody-positive impending myasthenic crisis: A retrospective cohort study [PDF]

Neurotherapeutics
Early intervention in impending myasthenic crisis (IMC) is critical to avert life-threatening progression. This study compared the clinical effectiveness and safety of the novel FcRn antagonist efgartigimod versus intravenous immunoglobulin (IVIg) in IMC
Rongjing Guo, Chao Sun, Xiaoxi Huang, Sijia Hao, Qingqing Wang, Zhe Ruan, Ting Gao, Yonglan Tang, Xiangqi Cao, Yu Liu, Zhuyi Li, Ting Chang   +11 more
doaj   +2 more sources

Analysis of events from sudden isolated dysarthria to diagnosis of myasthenic crisis: myasthenia gravis mimicking acute lacunar stroke—a case report [PDF]

Journal of Medical Case Reports
Background Myasthenic crisis (MC) is a life-threatening complication of myasthenia gravis (MG), necessitating ventilation. Achieving a safe and timely diagnosis of myasthenic crisis with atypical, isolated presentation is a considerable challenge ...
Simona Petkovic Miletic, Sheikh Ruksana Binte Ahmed   +1 more
doaj   +2 more sources

Eculizumab as Additional Rescue Therapy in Myasthenic Crisis [PDF]

Muscles
Eculizumab is a monoclonal antibody blocking the terminal complement protein C5. As demonstrated in the phase III randomized, placebo-controlled, REGAIN clinical trial, eculizumab is efficacious in acetylcholine receptor antibody (AChR-Ab)-positive ...
Francesco Crescenzo, Mattia Zanoni, Laura Ferigo, Francesca Rossi, Matteo Grecò, Angelica Lupato, Alessandra Danese, Domenico Ajena, Michelangelo Turazzini   +8 more
doaj   +2 more sources

First line treatment with subcutaneous efgartigimod in impending myasthenic crisis: a case report [PDF]

Therapeutic Advances in Neurological Disorders
In acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG), neonatal Fc-receptor (FcRn) inhibition has broadened the therapeutic spectrum. Myasthenic crisis (MC), heralded by an impending myasthenic crisis (iMC), is a critical
Isabelle Kwiedor, Martina Menacher, Monika Ellßel, Markus Naumann, Antonios Bayas   +4 more
doaj   +2 more sources

Efgartigimod versus intravenous immunoglobulin in the treatment of patients with impending myasthenic crisis [PDF]

Scientific Reports
Impending myasthenic crisis (IMC) is an emergent situation requiring aggressive management to prevent patients from developing myasthenic crisis (MC) in patients with myasthenia gravis (MG).
Jing Ma, Huiqiu Zhang, Junsen Zhao, Menghan Su, Yingna Feng, Xiaoli Yuan, Dan Liu, Xiaomin Pang, Rongjuan Zhao, Juan Wang, Weisong Duan, Xueli Chang, Junhong Guo, Wei Zhang   +13 more
doaj   +2 more sources

Complement Inhibition Therapy in Myasthenic Crisis-A Multicentre Retrospective Analysis of 17 Cases From Germany. [PDF]

Eur J Neurol
C5‐inhibition may represent an effective adjunctive treatment in therapy‐refractory myasthenic crisis, including thymoma‐associated MG (TAMG). ABSTRACT Introduction Generalized myasthenia gravis (gMG) may progress to life‐threatening myasthenic crises (MC) requiring mechanical ventilation.
Gerischer L, Stein M, Schneider A, Tangen H, Loris J, Glaubitz S, Zschüntzsch J, Oy UH, Schubert C, Heesen C, Schlag M, Hagenacker T, Oeztuerk M, Ruck T, Doksani P, Dusemund C, Herdick M, Herzig-Nichtweiß J, Mergenthaler P, Stascheit F, Suboh A, Schwarz L, Hoffmann S, Meisel A, Lehnerer S.   +24 more
europepmc   +2 more sources

Thymectomy immediately after myasthenic crisis [PDF]

Vojnosanitetski Pregled, 2021
Introduction. Myasthenic crisis ( MC) refers to rapid progression of myasthenic weakness accompanied by ventilatory and bulbar dysfunction. Since there is no single standard accepted in the treatment of every patient in myasthenic crisis, we report our ...
Martić Vesna, Marić Nebojša, Đorđević Dragan   +2 more
doaj   +1 more source

Takotsubo syndrome and myasthenic crisis after radiocontrast media-induced anaphylaxis: a case report [PDF]

Journal of Neurocritical Care, 2022
Background Takotsubo syndrome and myasthenic crisis can be triggered by physical stress. We present the case of a woman who developed Takotsubo syndrome and myasthenic crisis following radiocontrast media-induced anaphylaxis.
Jeong Hee Cho, Hyeongsoo Kim, Jungyon Yum   +2 more
doaj   +1 more source

COVID-19 patients in myasthenic crisis managed successfully with noninvasive positive pressure ventilation: a case series.

Critical Care Innovations, 2021
The management of respiratory failure during the present pandemic has been a challenging issue for the intensivists. There have been few case series and case reports on myasthenic crisis precipitated by severe acute respiratory syndrome coronavirus-2 ...
Mohd Mustahsin, Sanjay Choubey, Varun Malhotra   +2 more
doaj   +1 more source