Results 141 to 150 of about 35,534 (303)

Unveiling shocks in planetary nebulae [PDF]

, 2013
The propagation of a shock wave into a medium is expected to heat the material beyond the shock, producing noticeable effects in intensity line ratios such as [O III]/Halpha.
Guerrero, M. A., Luridiana, V., Medina, J. J., Miranda, L. F., Riera, A., Toalá, J. A., Velázquez, P. F.   +6 more
core   +1 more source

Epigenomics‐guided precision oncology: Chromatin variants in prostate tumor evolution

International Journal of Cancer, Volume 158, Issue 2, Page 314-332, 15 January 2026.
Abstract Prostate cancer is a common malignancy that in 5%–30% leads to treatment‐resistant and highly aggressive disease. Metastasis‐potential and treatment‐resistance is thought to rely on increased plasticity of the cancer cells—a mechanism whereby cancer cells alter their identity to adapt to changing environments or therapeutic pressures to create
Kira Furlano, Tina Keshavarzian, Nadine Biernath, Annika Fendler, Maria de Santis, Joachim Weischenfeldt, Mathieu Lupien   +6 more
wiley   +1 more source

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

Oncogenesis
The oncoprotein MYCN drives malignancy in various cancer types, including neuroblastoma (NB). However, our understanding of the mechanisms underlying its transcriptional activity and oncogenic function, as well as effective strategies to target it ...
Zhihui Liu, Jason J. Hong, Xiyuan Zhang, Carly M. Sayers, Wendy Fang, Man Xu, Sydney Loria, Sakereh Maskal, Haiyan Lei, Haitao Wu, Rolf Swenson, Jordan L. Meier, Jack F. Shern, Carol J. Thiele   +13 more
doaj   +1 more source

MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma

Cancer Cell International, 2017
Background MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need ...
Zhi-Xia Yue, Cheng Huang, Chao Gao, Tian-Yu Xing, Shu-Guang Liu, Xing-Jun Li, Qian Zhao, Xi-Si Wang, Wen Zhao, Mei Jin, Xiao-Li Ma   +10 more
doaj   +1 more source

An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]

, 2014
Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan, Carta, Alessia, Chetcuti, Rachel   +2 more
core   +4 more sources

RE: Comments on cIMPACT‐NOW Update 11

Brain Pathology, EarlyView.
Henning Leske, Richard Doughty, Pitt Niehusmann   +2 more
wiley   +1 more source

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

The long noncoding RNA linc-NeD125 controls the expression of medulloblastoma driver genes by microRNA sponge activity [PDF]

, 2017
Long noncoding RNAs (lncRNAs) are major regulators of physiological and disease-related gene expression, particularly in the central nervous system. Dysregulated lncRNA expression has been documented in several human cancers, and their tissue-specificity
Alfano, Vincenzo, Bevilacqua, Valeria, Bozzoni, Irene, Caffarelli, Elisa, Carai, Andrea, Carlo, Valerio Di, Favia, Annarita, Ferretti, Elisabetta, Laneve, Pietro, Legnini, Ivano, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Po, Agnese, Rea, Jessica   +14 more
core   +1 more source

A novel MYCN-YTHDF1 cascade contributes to retinoblastoma tumor growth by eliciting m^6A -dependent activation of multiple oncogenes

Science China Life Sciences, 2023
Yingxiu Luo, Mengjia He, Jie Yang, Feifei Zhang, Jie Chen, Xu-yang Wen, Jiayan Fan, Xianqun Fan, P. Chai, Renbing Jia   +9 more
semanticscholar   +1 more source

ZIP4 promotes glycolysis in cholangiocarcinoma cells by enhancing H3K4me3 modification and activating MYCN transcription

Zhongguo Linchuang Yixue
ObjectiveTo explore the mechanism by which zinc-regulated transporters, iron-regulated transporter-likeprotein 4 (ZIP4) regulates glycolysis and its impact on tumor progression in cholangiocarcinoma (CCA), providing a theoretical basis for targeted ...
Jiwen WANG, Cheng ZHANG, Dexiang ZHANG, Xiaoling NI, Kun FAN, Houbao LIU   +5 more
doaj   +1 more source