Results 121 to 130 of about 20,887 (223)
MYCN in neuroblastoma: The kings' new clothes and drugs
EJC Paediatric OncologyDeregulated levels of the MYCN oncogene contribute to the tumorigenesis of several human tumors including neuroblastoma. MYCN amplification classifies neuroendocrine tumors as high-risk and as a consequence is an unfavorable prognostic factor.
Mareike Müller +3 more
doaj +1 more source
Pheno-MYCN maps the morphological footprint of MYCN amplification in paediatric neuroblastoma
MYCN amplification has long been a prognostic marker in paediatric neuroblastoma, yet is typically assayed in bulk, alongside rather than within the heterogeneous tissue architecture pathologists assess.
Olga Fourkioti +7 more
core +1 more source
ALK upregulates POSTN and WNT signaling to drive neuroblastoma
Cell ReportsSummary: Neuroblastoma is the most common extracranial solid tumor of childhood. While MYCN and mutant anaplastic lymphoma kinase (ALKF1174L) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear.
Miller Huang +21 more
doaj +1 more source
A high-throughput screening platform to identify MYCN expression inhibitors for liver cancer therapy
Frontiers in OncologyMYCN, an oncogene implicated in hepatocellular carcinoma (HCC), is predominantly expressed in cancer stem-like HCC cells. It drives tumorigenicity, metastasis, and therapeutic resistance. In this study, we hypothesized that the pharmacological inhibition
Yali Xu +14 more
doaj +1 more source
, 2019 Supplementary Figure S2. PA2G4 increases MYCN protein stability. A and B, Representative immunoblots from cycloheximide (CHX) chase assays measuring the half-life of MYCN protein after PA2G4 knockdown (A) or overexpression (B) in BE(2)-C and Kelly cells ...
Belamy B. Cheung (7033121) +32 more
core +1 more source
, 2019 Supplementary Figure S3 F-G F, Left panel: Histopathologic and immunohistochemical analyses of MYCN;GFP tumors treated with vehicle (left) or WS6 (right).
Belamy B. Cheung (7033121) +32 more
core +1 more source
Gene sets regulated by MYCN derived from GSEA of MYCN regulated transcriptome.
Gene sets regulated by MYCN derived from GSEA of MYCN regulated transcriptome.
Xiyuan Zhang (4222438) +7 more
core +1 more source
Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis
Communications BiologyMYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders
Belamy B. Cheung +32 more
doaj +1 more source
The MYCN/miR-26a-5p/LIN28B regulatory axis controls MYCN-driven LIN28B upregulation in neuroblastoma
, 2014 The RNA binding protein LIN28B is an essential regulator of stem cell self-renewal and has been identified as a bona fide oncogene in neuroblastoma. LIN28B is known to enhance MYCN expression through downregulation of let-7 microRNAs (miRNAs). As part of
Carter, Daniel +9 more
core
MYCN cofactors assist MYCN to bind to DNA (supplementary to Fig 6).
(A) Metagene plots show that the knockdown of WDR5 results in a decrease of average WDR5 and MYCN signal at the WDR5 peak center when focused on MYCN-bound promoters defined in Fig 1E.
Xiyuan Zhang (4222438) +7 more
core +1 more source