Results 101 to 110 of about 27,758 (263)

MYCN induces cell-specific tumorigenic growth in RB1-proficient human retinal organoid and chicken retina models of retinoblastoma

Oncogenesis, 2022
Retinoblastoma is a rare, intraocular paediatric cancer that originates in the neural retina and is most frequently caused by bi-allelic loss of RB1 gene function. Other oncogenic mutations, such as amplification and increased expression of the MYCN gene,
Maria K. E. Blixt, Minas Hellsand, Dardan Konjusha, Han-Zhao Zhang, Sonya Stenfelt, M. Åkesson, N. Rafati, Tatsiana Tararuk, Gustav Stålhammar, Charlotta All-Eriksson, H. Ring, F. Hallböök   +11 more
semanticscholar   +1 more source

A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN -amplified neuroblastoma

Science Advances, 2023
MYCN amplification ( MNA ) is a defining feature of high-risk neuroblastoma (NB) and predicts poor prognosis. However, whether genes within or in close proximity to the MYCN amplicon also contribute to MNA + NB ...
Hai-Feng Zhang, Alberto Delaidelli, Sumreen Javed, Busra Turgu, Taylor Morrison, Christopher S. Hughes, Xiaqiu Yang, Manideep Pachva, Michael M. Lizardo, Gurdeep Singh, Jennifer Hoffmann, Yue Zhou Huang, Khushbu Patel, Rawan Shraim, Sonia H. Y. Kung, Gregg B. Morin, Samuel Aparicio, Daniel Martinez, John M. Maris, Kristopher R. Bosse, Karla C. Williams, Poul H. Sorensen   +21 more
openaire   +2 more sources

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

ZIP4 promotes glycolysis in cholangiocarcinoma cells by enhancing H3K4me3 modification and activating MYCN transcription

Zhongguo Linchuang Yixue
ObjectiveTo explore the mechanism by which zinc-regulated transporters, iron-regulated transporter-likeprotein 4 (ZIP4) regulates glycolysis and its impact on tumor progression in cholangiocarcinoma (CCA), providing a theoretical basis for targeted ...
Jiwen WANG, Cheng ZHANG, Dexiang ZHANG, Xiaoling NI, Kun FAN, Houbao LIU   +5 more
doaj   +1 more source

CD133 expression and amplification induce chemoresistance and reduce average survival time in pediatric neuroblastoma

Journal of International Medical Research, 2018
Objectives Neuroblastoma (NB) is the most common pediatric solid tumor derived from the sympathetic nervous system. MYCN is amplified in nearly half of patients with NB, and its association with rapid disease progression and poor outcome is controversial.
Zhi-Yong Zhong, Bao-Jun Shi, Hui Zhou, Wen-Bo Wang   +3 more
doaj   +1 more source

Molecular and in vivo characterization of cancer-propagating cells derived from MYCN-dependent medulloblastoma [PDF]

, 2015
Medulloblastoma (MB) is the most common malignant pediatric brain tumor. While the pathways that are deregulated in MB remain to be fully characterized, amplification and/or overexpression of theMYCNgene, which is has a critical role in cerebellar ...
Veronica Gil, Zai Ahmad, Howell, Louise, Jasnos, Lukasz, Chesler, Louis, Albert Hallsworth, Louis Chesler (194638), Ahmad, Zai, Gil, Veronica, Kevin Petrie, Louis Chesler, Zai Ahmad (705159), Lukasz Jasnos (705160), Louise Howell, Kevin Petrie (705163), Tomoyuki Sawado (705164), Albert Hallsworth (194635), Hallsworth, Albert, Lukasz Jasnos, Tomoyuki Sawado, Veronica Gil (705161), Petrie, Kevin, Sawado, Tomoyuki, Louise Howell (705162), Howell Louise, Hallsworth Albert, Jasnos Lukasz, Sawado Tomoyuki, Chesler Louis, Petrie Kevin, Ahmad Zai, Gil Veronica   +31 more
core   +1 more source

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence [PDF]

Journal of Clinical Investigation, 2017
The most frequent focal alterations in human retinoblastoma are mutations in the tumor-suppressor gene retinoblastoma (RB) and amplification of the oncogene MYCN. Whether MYCN overexpression drives retinoblastoma has not been assessed in model systems. Here, we have shown that Rb inactivation collaborates strongly with MYCN overexpression and leads to ...
Nan, Wu, Deshui, Jia, Breanna, Bates, Ryan, Basom, Charles G, Eberhart, David, MacPherson   +5 more
openaire   +2 more sources

Impaired Antitumor Immune Response in MYCN-amplified Neuroblastoma Is Associated with Lack of CCL2 Secretion and Poor Dendritic Cell Recruitment

Cancer Research Communications, 2022
In neuroblastoma, MYCN amplification is associated with sparse immune infiltrate and poor prognosis. Dendritic cells (DC) are crucial immune sentinels but their involvement in neuroblastoma pathogenesis is poorly understood.
Jamila Kacher, O. Manches, C. Aspord, H. Sartelet, L. Chaperot   +4 more
semanticscholar   +1 more source

The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression

Journal of Experimental & Clinical Cancer Research, 2020
Background The oncogene MYCN is critical for tumorigenesis of several types of cancers including neuroblastoma. We previously reported that miR-506-3p repressed MYCN expression in neuroblastoma cells. However, the mechanism underlying such regulation was
Zhenze Zhao, Spencer D. Shelton, Alejandro Oviedo, Amy L. Baker, Collin P. Bryant, Soroush Omidvarnia, Liqin Du   +6 more
doaj   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source