Results 111 to 120 of about 20,887 (223)

Molecular and clinical features of a Japanese medulloblastoma cohort: Subgroup‐specific prognostic stratification using economical/accessible diagnostic methods

Brain Pathology, Volume 36, Issue 5, September 2026.
This study characterizes the molecular subgroup–specific features of a nationwide Japanese cohort comprising 242 medulloblastomas (MBs). Furthermore, we introduce SEE‐6‐CNA, a simple, cost‐effective, and FFPE‐compatible molecular test that is applicable to routine pathology samples and serves as a surrogate for risk stratification in non‐WNT/non‐SHH ...
Kohichi Go, Asako Katsuma, Ema Yoshioka, Tomoko Shofuda, Kohei Fukuoka, Koichi Ichimura, Yuko Matsushita, Yohei Mineharu, Yasuhide Makino, Takeshi Kawauchi, Atsushi Sasaki, Junko Hirato, Takeshi Inoue, Yoshinori Kodama, Masayuki Mano, Daisuke Kanematsu, Noriyuki Kijima, Naoki Kagawa, Dai Keino, Akitake Mukasa, Tomonari Suzuki, Koji Yoshimoto, Daisuke Kuga, Keishi Horiguchi, Shigeru Yamaguchi, Masayuki Kanamori, Kai Yamasaki, Kenichi Ishibashi, Takuya Akai, Masayoshi Yamaoka, Ryuji Ishizaki, Atsufumi Kawamura, Shigeo Ohba, Joji Ishida, Ryo Ando, Junya Fukai, Tomoru Miwa, Masazumi Fujii, Ai Muroi, Kuniaki Saito, Atsuko Harada, Yasuhiko Hayashi, Masahiro Nonaka, Young‐Soo Park, Yusuke Kobayashi, Tadashi Higuchi, Yosuke Miyairi, Kazuhisa Yoshifuji, Noriyoshi Takebe, Soichi Oya, Kosuke Nakajo, Mitsutoshi Nakada, Yoshiteru Nakano, Mizuki Kambara, Koji Adachi, Kazuhiro Tanaka, Hideo Nakamura, Yukihiko Sonoda, Ryuta Saito, Takafumi Wataya, Kazuhiko Kurozumi, Michael D. Taylor, Yoshitaka Narita, Soichiro Shibui, Hajime Arai, Hiroaki Sakamoto, Isao Date, Motoo Nagane, Ryo Nishikawa, Yoshiki Arakawa, Yonehiro Kanemura   +70 more
wiley   +1 more source

Editorial: Targeting MYCN in Pediatric Cancers [PDF]

Frontiers in Oncology, 2015
MYCN is the product of a gene frequently deregulated in childhood tumors that belongs to a small but very famous family of transcription factors whose prototype member is c-MYC. The other member of the family is L-MYC, identified as a gene amplified in a subset of lung cancers.
openaire   +3 more sources

Abstract 4758: A new syngeneic MYCN-overexpressing neuroblastoma mouse model and MYCN-DNA vaccine

, 2010
Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. High-level expression of MycN caused by amplification of the gene plays an important role in maintaining the malignant phenotype of NB and is the most significant marker for ...
Diana Seidel, Nicole Huebener, Alexander Stermann, Holger N. Lode, Anastasia Shibina, Gerhard Gaedicke, Stefan Fest   +6 more
core   +1 more source

MYCN and KAT2A form a feedforward loop to drive an oncogenic transcriptional program in neuroblastoma

Oncogenesis
The oncoprotein MYCN drives malignancy in various cancer types, including neuroblastoma (NB). However, our understanding of the mechanisms underlying its transcriptional activity and oncogenic function, as well as effective strategies to target it ...
Zhihui Liu, Jason J. Hong, Xiyuan Zhang, Carly M. Sayers, Wendy Fang, Man Xu, Sydney Loria, Sakereh Maskal, Haiyan Lei, Haitao Wu, Rolf Swenson, Jordan L. Meier, Jack F. Shern, Carol J. Thiele   +13 more
doaj   +1 more source

Supplementary Figure S1 F-I from Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

, 2019
Supplementary Figure S1. F, Confocal microscopy of SHEP Tet21N cells using anti-PA2G4 (red) and anti-MYCN (green) antibodies. G, Immunoblot analysis of cytoplasmic and nuclear fractions from BE(2)-C and Kelly human neuroblastoma cell lines with ...
Belamy B. Cheung (7033121), Michelle Haber (14933688), Brendan W. Stevenson (14945191), Glenn M. Marshall (9902807), Jessica Koach (322264), Bryce Keenan (8851166), Michael A. Gorman (14945194), Janith A. Seneviratne (12588178), Andre Oberthuer (5649652), Joshua A. McCarroll (12502138), Bing Liu (70818), Shizhen Zhu (51843), Jessica L. Bell (14945197), Jamie I. Fletcher (14942868), Matthias Fischer (76016), Murray D. Norris (14936951), Giovanni Perini (133035), Olivia C. Ciampa (14945182), Tao Liu (10785), Giorgio Milazzo (5090288), Stefan Hüttelmaier (76632), Daniel R. Carter (7033118), W. Clay Gustafson (14945200), Jessica K. Holien (14241329), Michael W. Parker (14945203), Taylor Lim (9989364), Jayne E. Murray (14945188), Chelsea Mayoh (14933682), Mika Herath (14945185), Hassina Massudi (313890), Andrew J. Gifford (3615305), Larissa Doughty (391900), Xiaoling Zhang (420384)   +32 more
core   +1 more source

MYCN in human development and diseases

Frontiers in Oncology
Somatic mutations in MYCN have been identified across various tumors, playing pivotal roles in tumorigenesis, tumor progression, and unfavorable prognoses. Despite its established notoriety as an oncogenic driver, there is a growing interest in exploring the involvement of MYCN in human development.
Yosuke Nishio, Yosuke Nishio, Yosuke Nishio, Kohji Kato, Kohji Kato, Kohji Kato, Hisashi Oishi, Yoshiyuki Takahashi, Shinji Saitoh   +8 more
openaire   +3 more sources

Targeting MYCN in Pediatric Solid Tumors [PDF]

, 2014
MYC proteins are critical drivers of a wide range of cancers, and as transcription factors are generally considered undruggable. MYCN is the neuroblastoma-derived isoform of MYC and is a driving oncogene in neuroblastoma and medulloblastoma, two deadly ...
Meyerowitz, Justin Gabriel
core  

MYCN protein partners identified in NB cells.

MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood.
Xiyuan Zhang (4222438), Zhihui Liu (95891), Haiyan Lei (234120), Man Xu (406648), Jason J. Hong (18272287), Carol J. Thiele (9282911), Amanda Ciardiello (18272290), Jack F. Shern (10183017)   +7 more
core   +1 more source

MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription.

PLoS Biology
MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis, and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood.
Zhihui Liu, Xiyuan Zhang, Man Xu, Jason J Hong, Amanda Ciardiello, Haiyan Lei, Jack F Shern, Carol J Thiele   +7 more
doaj   +1 more source

MYCN is amplified during S phase, and c-myb is involved in controlling MYCN expression and amplification in MYCN-amplified neuroblastoma cell lines

, 2019
Neuroblastoma derived from primitive sympathetic neural precursors is a common type of solid tumor in infants. MYCN proto-oncogene bHLH transcription factor (MYCN) amplification and 1p36 deletion are important factors associated with the poor prognosis ...
Aygun, Nevim, Altungöz, Oğuz
core   +1 more source