Results 171 to 180 of about 10,096 (205)

MYCN AMPLIFICATION IN MEDULLOBLASTOMA

Pediatric Pathology & Molecular Medicine, 1998
Prominent neuronal differentiation and MYCN amplification occur only in a small percentage of medulloblastomas (primitive neuroectodermal tumor of the cerebellum). In this article, we describe two medulloblastomas that showed a striking degree of neuronal differentiation with islands of mature neurons associated with abundant neuropil.
Venita Jay, Paula Marrano, Maria Zielenska   +2 more
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MYCN Amplification by Differential PCR

Pediatric Hematology and Oncology, 1993
A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials.
S N, Huddart, J R, Mann, A G, McGukin, R, Corbett   +3 more
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MYCN gain and MYCN amplification in a stage 4S neuroblastoma

Cancer Genetics and Cytogenetics, 2003
Stage 4S neuroblastoma is a disease associated with spontaneous regression and good survival. We present a patient whose evolution has shown the variety and complexity of this disease in infants. Biologic factors, such as ploidy, MYCN copy number, loss of 1p36, and other chromosomal gains and losses were determined.
Rosa, Noguera, Adela, Cañete, Antonio, Pellín, Amparo, Ruiz, María, Tasso, Samuel, Navarro, Victoria, Castel, Antonio, Llombart-Bosch   +7 more
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Concomitant p53 mutation and MYCN amplification in neuroblastoma

Medical and Pediatric Oncology, 1997
The MYCN oncogene is amplified in 20% of childhood neuroblastoma and is associated independently with poor prognosis. Alteration of the p53 tumor supressor gene, in contrast, occurs infrequently in these tumors. In this report, we described a 3-year-old girl with stage IV neuroblastoma.
R, Manhani, L M, Cristofani, V, Odone Filho, I, Bendit   +3 more
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Episomal amplification of MYCN in a case of medulloblastoma

Virchows Archiv, 2008
Gene amplification, in the form of double minutes (dmin) and/or homogeneously staining regions (hsr), is frequently associated with tumor development. A well-known example is neuroblastoma for which MYCN gene (v-myc myelocytomatosis viral-related oncogene) amplification has a relevant prognostic significance.
Surace C, Pedeutour F, Trombetta D, Burel Vandenbos F, ROCCHI, Mariano, STORLAZZI, CLELIA TIZIANA   +5 more
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MYCN amplification in spinal ependymoma: A five‐year retrospective study

Neuropathology, 2023
Spinal ependymoma with MYCN amplification is a newly recognized type of spinal ependymoma that is known to be associated with poor prognosis. Available studies on this relatively rare tumor type have observed that these tumors tend to disseminate along the spinal cord and behave aggressively with worse overall and progression‐free survival compared to ...
Shilpa Rao, Harsha Sugur, Subhas Konar, Arimappamagan Arivazhagan, Vani Santosh   +4 more
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MYCN-status in neuroblastoma: characteristics of tumours showing amplification, gain, and non-amplification

European Journal of Cancer, 2004
While the role of MYCN-amplification (MNA) for risk assessment in neuroblastoma is undisputed, the phenomenon of gene copy excess below the amplification threshold is rarely described. To discuss biological characteristics and the clinical impact of the so-called MYCN-gain versus amplified or non-amplified cases, we investigated the MYCN status of 659 ...
Ruediger, Spitz, B, Hero, M, Skowron, K, Ernestus, F, Berthold   +4 more
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Analysis of candidate gene co-amplification with MYCN in neuroblastoma

European Journal of Cancer, 1997
Previous studies have revealed that the MYCN gene spans approximately 7kb, while the amplicon has been estimated to be 100 kb to 1 Mb long [1-3]. This implies that several other genes may be present on the MYCN amplicon. Such co-amplified genes could contribute to the malignant phenotype and might provide an explanation for why not all patients with ...
George RE, Kenyon R, McGuckin AG, Kohl N, Kogner P, Christiansen H, Pearson ADJ, Lunec J   +7 more
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MYCN amplification and 17q in neuroblastoma: Evidence for structural association

Genes, Chromosomes and Cancer, 2000
MYCN oncogene amplification in neuroblastoma is statistically associated with gain of chromosome segment 17q21-qter. In neuroblastoma cell lines and primary tumors with MYCN amplification in the form of homogeneously staining regions (hsrs), juxtaposition of chromosome 17 material with MYCN sequences has occasionally been reported, raising the ...
S, O'Neill, L, Ekstrom, M, Lastowska, P, Roberts, G M, Brodeur, U R, Kees, M, Schwab, N, Bown   +7 more
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Heterogeneous MYCN amplification in neuroblastoma

2010
Unter den 110 MYCN amplifizierten (MNA) Neuroblastomen, die in den letzten 10 Jahren am CCRI analysiert wurden, befanden sich 26 Tumore mit variierender Anzahl von Tumorzellen oder Arealen ohne MNA. In Übereinstimmung mit den Richtlinien der INRG Biologie Gruppe wurden diese Tumore als „heterogen MYCN- amplifiziert (hetMNA)“ eingestuft.
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