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Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior

Journal of Neuropathology and Experimental Neurology, 2019
Adult spinal cord ependymomas are typically low grade and have a relatively favorable clinical course following gross total resection. We report 4 cases of anaplastic spinal cord ependymoma with MYCN amplification, an exceptionally rare finding.
Aditya Raghunathan, Timothy Kaufmann, Robert Jenkins   +2 more
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Secondary enucleated retinoblastoma with MYCN amplification

Ophthalmic Genetics, 2021
Background: Absence of RB1 mutation is rare in retinoblastoma and MYCN amplifications were recently identified in a subset of aggressive retinoblastomas occurring in infants. Here we describe not only the clinical phenotype of MYCN retinoblastoma at presentation, but also the tumor response to the first attempt of conservative management in this ...
Alexandre P, Moulin, Christina, Stathopoulos, Fabienne, Marcelli, Jacqueline, Schoumans Pouw, Maja, Beck-Popovic, Francis L, Munier   +5 more
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MYCN AMPLIFICATION IN MEDULLOBLASTOMA

Pediatric Pathology & Molecular Medicine, 1998
Prominent neuronal differentiation and MYCN amplification occur only in a small percentage of medulloblastomas (primitive neuroectodermal tumor of the cerebellum). In this article, we describe two medulloblastomas that showed a striking degree of neuronal differentiation with islands of mature neurons associated with abundant neuropil.
Venita Jay, Paula Marrano, Maria Zielenska   +2 more
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MYCN Amplification by Differential PCR

Pediatric Hematology and Oncology, 1993
A method is described to estimate MYCN (N-myc) oncogene amplification in neuroblastoma by the technique of differential polymerase chain reaction (PCR). The technique is quicker than conventional Southern blotting techniques and does not require radioactive materials.
S N, Huddart, J R, Mann, A G, McGukin, R, Corbett   +3 more
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MYCN gain and MYCN amplification in a stage 4S neuroblastoma

Cancer Genetics and Cytogenetics, 2003
Stage 4S neuroblastoma is a disease associated with spontaneous regression and good survival. We present a patient whose evolution has shown the variety and complexity of this disease in infants. Biologic factors, such as ploidy, MYCN copy number, loss of 1p36, and other chromosomal gains and losses were determined.
Rosa, Noguera, Adela, Cañete, Antonio, Pellín, Amparo, Ruiz, María, Tasso, Samuel, Navarro, Victoria, Castel, Antonio, Llombart-Bosch   +7 more
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Episomal amplification of MYCN in a case of medulloblastoma

Virchows Archiv, 2008
Gene amplification, in the form of double minutes (dmin) and/or homogeneously staining regions (hsr), is frequently associated with tumor development. A well-known example is neuroblastoma for which MYCN gene (v-myc myelocytomatosis viral-related oncogene) amplification has a relevant prognostic significance.
Surace C, Pedeutour F, Trombetta D, Burel Vandenbos F, ROCCHI, Mariano, STORLAZZI, CLELIA TIZIANA   +5 more
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Role of MRI radiomics for the prediction of MYCN amplification in neuroblastomas

European Radiology, 2023
We evaluate MR radiomics and develop machine learning-based classifiers to predict MYCN amplification in neuroblastomas.A total of 120 patients with neuroblastomas and baseline MR imaging examination available were identified of whom 74 (mean age ± standard deviation [SD] of 6 years and 2 months ± 4 years and 9 months; 43 females and 31 males, 14 MYCN ...
Adarsh Ghosh, Ensar Yekeler, Sara Reis Teixeira, Deepa Dalal, Lisa States   +4 more
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Concomitant p53 mutation and MYCN amplification in neuroblastoma

Medical and Pediatric Oncology, 1997
The MYCN oncogene is amplified in 20% of childhood neuroblastoma and is associated independently with poor prognosis. Alteration of the p53 tumor supressor gene, in contrast, occurs infrequently in these tumors. In this report, we described a 3-year-old girl with stage IV neuroblastoma.
R, Manhani, L M, Cristofani, V, Odone Filho, I, Bendit   +3 more
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Cavitary retinoblastoma with MYCN amplification

Journal of American Association for Pediatric Ophthalmology and Strabismus
MYCN amplification within the tumor has emerged as an important factor in the oncogenesis of a subset of retinoblastomas, most of which are caused by pathogenic variants in the RB1 gene. We present the case of a 3-month-old girl with unilateral cavitary retinoblastoma that initially responded well to intra-arterial chemotherapy but later recurred ...
Kathryn E. Tobert, Nicole Liberio, Kerri Becktell, Aparna Ramasubramanian   +3 more
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Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors

Cancer Genetics and Cytogenetics, 2009
Ploidy is an important biologic feature defining heterogeneous neuroblastoma. To clarify whether centrosome amplification is correlated with ploidy status or MYCN amplification, we examined centrosomes by immunostaining, and ploidy and MYCN copy numbers by fluorescence in situ hybridization in 27 neuroblastomas.
Daisuke, Fukushi, Naoki, Watanabe, Fumio, Kasai, Masayuki, Haruta, Akira, Kikuchi, Atsushi, Kikuta, Koji, Kato, Hisaya, Nakadate, Yukiko, Tsunematsu, Yasuhiko, Kaneko   +9 more
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