Results 171 to 180 of about 272,512 (195)

Rearrangement in the Coding Region of the MYCN Gene in a Subset of Amplicons in a Case of Neuroblastoma With MYCN Amplification

Diagnostic Molecular Pathology, 2001
The MYCN gene is often amplified but rarely rearranged in neuroblastoma. We report, for the first time, a rearrangement within the MYCN coding region in a metastatic neuroblastoma in a 3-year-old boy with MYCN amplification in his primary tumor. The rearrangement occurred 46 nucleotides downstream from the ATG codon in exon 2 of MYCN. The amplification
B, Chen, S C, Jhanwar, M, Ladanyi
openaire   +2 more sources

MYCN amplification and 17q in neuroblastoma: Evidence for structural association

Genes, Chromosomes and Cancer, 2000
MYCN oncogene amplification in neuroblastoma is statistically associated with gain of chromosome segment 17q21-qter. In neuroblastoma cell lines and primary tumors with MYCN amplification in the form of homogeneously staining regions (hsrs), juxtaposition of chromosome 17 material with MYCN sequences has occasionally been reported, raising the ...
S, O'Neill, L, Ekstrom, M, Lastowska, P, Roberts, G M, Brodeur, U R, Kees, M, Schwab, N, Bown   +7 more
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MYC and MYCN amplification can be reliably assessed by aCGH in medulloblastoma

Cancer Genetics, 2013
As prognostic factors, MYC and MYCN amplifications are routinely assessed in medulloblastomas. Fluorescence in situ hybridization (FISH) is currently considered as the technique of reference. Recently, array comparative genomic hybridization (aCGH) has been developed as an alternative technique to evaluate genomic abnormalities in other tumor types ...
Franck, Bourdeaut, Camille, Grison, Claude-Alain, Maurage, Annie, Laquerriere, Alexandre, Vasiljevic, Marie-Bernadette, Delisle, Sophie, Michalak, Dominique, Figarella-Branger, François, Doz, Wilfrid, Richer, Gaelle, Pierron, Catherine, Miquel, Olivier, Delattre, Jérôme, Couturier   +13 more
openaire   +2 more sources

An Infant With Neuroblastoma and MYCN Amplification Found Through Mass Screening

Journal of Pediatric Hematology/Oncology, 1998
This report describes an extremely rare case of an infant with neuroblastoma involving MYCN amplification found through mass screening (MS).An 8-month-old boy was referred to our hospital after screening for neuroblastoma showed positive results. A firm tumor was found above his left kidney and completely resected.The tumor arose from the left adrenal ...
T, Taga, N, Okamoto, T, Hisano, T, Tanaka, M, Shimada, H, Okabe, H, Shimada, S, Ohta   +7 more
openaire   +2 more sources

The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification

Cancer Letters, 2003
Neuroblastoma is a tumour of the peripheral nervous system that accounts for 15% of cancer-related deaths in childhood. Amplification and overexpression of the MYCN proto-oncogene occurs in 25% of neuroblastomas and is highly correlated with treatment failure and mortality.
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MYCN gene amplification in patients with neuroblastic tumors.

Cellular and molecular biology (Noisy-le-Grand, France), 2015
Although neuroblastic tumors are the most prevalent solid tumors, little is known about the genetic basis underlying their progression. The prognostic role for the MYCN gene in neuroblastic tumors is irrefutable. The aim of this study is to identify the frequency of MYCN gene amplification and its relationship with clinicopathological and prognostic ...
M A, Estiar, H, Fazilaty, S, Aslanabadi, M, Seifi, P, Varghaei, A, Rezamand   +5 more
openaire   +1 more source

Circulating MYCN DNA Predicts MYCN-Amplification in Neuroblastoma

Journal of Clinical Oncology, 2005
Valérie, Combaret, Christophe, Bergeron, Rosa, Noguera, Isabelle, Iacono, Alain, Puisieux   +4 more
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Single nCounter assay for prediction of MYCN amplification and molecular classification of medulloblastomas: a multicentric study

Journal of Neuro-Oncology, 2022
Luciane Sussuchi da Silva, Reis Rm, Glaucia N M Hajj   +2 more
exaly  

[Study on MYCN gene amplification and CD44 expression in neuroblastoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 2005
To assess the relationship between MYCN amplification in neuroblastoma (NB), tumor stage and prognosis; and to evaluate the usefulness of CD44 in predicting prognosis of NB.Differential polymerase chain reaction (D-PCR) with serial dilution assay was used to quantify the MYCN gene copy number in 33 paraffin-embedded tissue samples of NB.
Hui-li, Hu, Le-jian, He
openaire   +1 more source

Predicting Amplification of MYCN using CpG Methylation Biomarkers in Neuroblastoma

Future Oncology, 2021
Hocine Bendou, Abdulazeez Giwa, Junaid Gamieldien   +2 more
exaly