Results 241 to 250 of about 367,380 (311)

Deep learning‐based structure modeling of the Treponema pallidum proteome: Insights into pathogenesis and syphilis vaccine development

open access: yesProtein Science, Volume 35, Issue 12, December 2026.
Abstract Treponema pallidum ssp. pallidum, the causative agent of syphilis, has a small proteome and encompasses numerous strains. Knowledge gaps remain in understanding the molecular mechanisms of pathogenesis of this bacterium, as well as the structure and function of the full complement of proteins encoded by T. pallidum.
Simon Houston   +5 more
wiley   +1 more source

Characterization of the Lysophosphatidic Acid Receptor 5 Antagonist RLPA‐76 as a Novel Analgesic in Male Rats and Mice

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT Clinically used analgesics such as gabapentinoids and opioids have limited efficacy and adverse effects like abuse liability, and there is a dire need for novel analgesics with improved safety profiles. Since lysophosphatidic acid can induce neuropathic pain in rodents, LPA receptor antagonists have been investigated as potential analgesics ...
Kristen L. Woodhouse   +6 more
wiley   +1 more source

Influence of the Nature of the Cationic Residues on the Activity of the Antimicrobial Peptides of the Lynronne Family

open access: yesJournal of Peptide Science, Volume 32, Issue 12, December 2026.
Derivatives of Lynronnes with cationic residues substitution were designed and tested in terms of antimicrobial activity, anti‐biofilm activity, mechanism of action, and in vitro toxicity. Lys‐substitution emerges as a promising strategy for improved activity and selectivity, particularly against E. coli. ABSTRACT Most antimicrobial peptides (AMPs) are
Alexis Reinbold   +17 more
wiley   +1 more source

An Effective Diagnostic Approach for Successful Recovery from <i>Mycobacterium avium</i> Systemic Infection in a Basset Hound Dog. [PDF]

open access: yesVet Sci
Zoppi S   +7 more
europepmc   +1 more source

Biological, Environmental, and Social Determinants of Buruli Ulcer in Africa: Their Interplay Across Disease Severity and Patient Outcome

open access: yesPublic Health Challenges, Volume 5, Issue 4, December 2026.
Buruli ulcer is caused by Mycobacterium ulcerans and its toxin, mycolactone. Disease outcomes are influenced by biological, environmental, and social determinants. Biological factors include immune response and lesion severity. Environmental factors include aquatic exposure, rainfall, flooding, and ecological changes.
Gudisa Bereda
wiley   +1 more source

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