Results 131 to 140 of about 68,917 (249)

Repurposing of FDA‐Approved Drugs to Disrupt Iron Uptake in Mycobacterium abscessus: Targeting Salicylate Synthase as a Novel Approach

Chemical Biology &Drug Design, Volume 106, Issue 2, August 2025.
A drug repurposing strategy was applied against M. abscessus, through a virtual screening of FDA approved drugs on salicylate synthase. Eleven potential ligands were found; among these, three were confirmed as potent inhibitors of the enzyme. ABSTRACT Non‐tuberculous mycobacteria (NTM) are opportunistic pathogens that lead to severe, persistent ...
Giovanni Stelitano, Christian Bettoni, Matteo Mori, Mario Cocorullo, Andrea Tresoldi, Fiorella Meneghetti, Stefania Villa, Laurent R. Chiarelli   +7 more
wiley   +1 more source

Mycobacterium smegmatis Skin Infection Following Cosmetic Procedures: Report of Two Cases

Clinical, Cosmetic and Investigational Dermatology, 2022
Caroline J Wang,1 Yinggai Song,2,3 Tingting Li,1 Jian Hu,1 Xue Chen,1 Houmin Li1 1Department of Dermatology, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Dermatology, Peking University First Hospital, Beijing ...
Wang CJ, Song Y, Li T, Hu J, Chen X, Li H   +5 more
doaj  

Lupus Vulgaris on Face: A Case Report From Rural Nepal

Clinical Case Reports, Volume 13, Issue 7, July 2025.
ABSTRACT Lupus vulgaris (LV), the most common form of cutaneous tuberculosis, results from Mycobacterium tuberculosis infection via hematogenous, lymphatic, or direct transmission in individuals with moderate immunity and high tuberculin sensitivity. It predominantly affects females, constituting 1%–2% of extrapulmonary tuberculosis cases, with facial ...
Sabin Kandel, Nikita Shah, Aayush Bist
wiley   +1 more source

Prolonged Outbreak of Mycobacterium chimaera Infection After Open-Chest Heart Surgery [PDF]

, 2017
A thorough epidemiological and microbiological investigation of this prolonged outbreak involving 6 open-chest heart surgery patients provided evidence for the airborne transmission of Mycobacterium chimaera, a slow-growing nontuberculous mycobacteria ...
Achermann, Yvonne, Bloemberg, Guido, Böttger, Erik C., Falk, Volkmar, Hasse, Barbara, Kohler, Philipp, Kuster, Stefan P., Rössle, Matthias, Sax, Hugo, Sommerstein, Rami, Weber, Rainer   +10 more
core  

Tuberculosis in a Psychiatric Hospital in the state of Goiás, Brazil [PDF]

, 2006
OBJECTIVE: To investigate the prevalence of infection, disease and eventual institutional outbreak of tuberculosis in a psychiatric hospital using the PPD test, as well as testing for mycobacteria in material collected from the respiratory tree and using
Costa, Hindenburg Cruvinel Guimarães Da, Leite, Clarice Queico Fujimura, Malaspina, Ana Carolina, Mello, Fernando Augusto Fiúza De   +3 more
core   +2 more sources

Prevalence and risk factors of pulmonary nontuberculous mycobacterial infections in the Zhejiang Province of China

Epidemiology and Infection, 2019
Risk factors and prevalence of pulmonary nontuberculous mycobacterial (NTM) diseases were retrospectively evaluated in 1208 suspected pulmonary TB patients seeking care at the Affiliated Hospital of Hangzhou Normal University between July 2018 and ...
Jintian Xu, Ping Li, Shengchao Zheng, W. Shu, Y. Pang   +4 more
semanticscholar   +1 more source

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

ChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda, Daria Nawrot, Petr Šlechta, Miroslav Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source

Clinical findings in relation to mortality in non-tuberculous mycobacterial infections : patients with Mycobacterium avium complex have better survival than patients with other mycobacteria [PDF]

, 2015
We compared the clinical findings and survival in patients with Mycobacterium avium complex (MAC) and other non-tuberculous mycobacteria (NTM). A total of 167 adult non-human immunodeficiency virus (HIV) patients with at least one positive culture for ...
Eskola, J., Jarvinen, A., Kotilainen, H., Poussa, T., Tukiainen, P., Valtonen, V.   +5 more
core   +1 more source

Advances in bronchiectasis:endotyping, genetics, microbiome, and disease heterogeneity [PDF]

, 2018
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the radiographic demonstration of airway enlargement is the common feature of a heterogeneous set of conditions and clinical presentations.
Chalmers, James D., Flume, Patrick A., Olivier, Kenneth N.   +2 more
core   +2 more sources

MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections

Frontiers in Microbiology, 2018
Nontuberculous mycobacterial (NTM) pulmonary infections are emerging as a global health problem and pose a threat to susceptible individuals with structural or functional lung conditions such as cystic fibrosis, chronic obstructive pulmonary disease and ...
Wei Li, Amira Yazidi, Amit N. Pandya, P. Hegde, Weiwei Tong, Vinicius Calado Nogueira de Moura, E. J. North, J. Sygusch, M. Jackson   +8 more
semanticscholar   +1 more source