Results 111 to 120 of about 1,040,351 (259)

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

Interdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang, Baoyuan Zhu, Yuanyuan Huang, Liqin Liang, Zhaobo Li, Yunheng Diao, Minxin Guo, Heng Zhang, Jing Zhou, Fengchun Wu, Kai Wu   +10 more
wiley   +1 more source

Pacemaker pocket infection due to Mycobacterium abscessus subspecies abscessus: A Case Report and Literature Review [PDF]

Medical Laboratory Journal
Background: Mycobacterium abscessus is a rapidly growing non-tuberculous mycobacterium that can cause various infections in humans. The identification of nontuberculous mycobacteria remains a challenge to date due to the availability of limited resources.
Maanasa Bhaskar Manalikandy, Ankita Mohanty, Noyal Maria Joseph, Raja Jaisundar Selvaraj, Sujatha Sistla   +4 more
doaj  

Non-tuberculous mycobacteria enhance the tryptophan-kynurenine pathway to induce immunosuppression and facilitate pulmonary colonization

Frontiers in Cellular and Infection Microbiology
The increasing prevalence of non-tuberculous mycobacterium (NTM) infections alongside tuberculosis (TB) underscores a pressing public health challenge. Yet, the mechanisms governing their infection within the lung remain poorly understood.
Longjie Li, Longjie Li, Jiaofang Shao, Chunran Tong, Weiwei Gao, Pan Pan, Chen Qi, Chenxi Gao, Yunlei Zhang, Yunlei Zhang, Ying Zhu, Cheng Chen   +11 more
doaj   +1 more source

Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers

, 2008
The ability to construct defined deletions of Mycobacterium tuberculosis has allowed many genes involved in virulence to be identified. Deletion of nutritional genes leads to varying levels of attenuation, presumably reflecting the need for a particular ...
Williams, A, Williams, Ann, Clark, S, Clark, Simon, Smith, D, Hatch, Graham, Movahedzadeh, F, Stoker, N G, Movahedzadeh, Farahnaz, Bacon, Joanna, Parish, T, LSHTM, Ten Bokum, A M C, Parish, Tanya, Hatch, G, Smith, Debbie, HPA, Bacon, J, ten Bokum, Annemieke, Stoker, Neil   +19 more
core   +1 more source

Organ‐Specific Human Microbiomes and Dysbiosis: Mechanistic Links to Disease and Emerging Therapeutic Strategies

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic overview of the human microbiome and major microbiota‐derived metabolites across body sites, highlighting the gut–brain, gut–heart, and gut–kidney axes in host physiology and disease. ABSTRACT Background The human microbiome is a dynamic and diverse community of microorganisms that affects susceptibility to illness and promotes wellness ...
Awadh Alanazi
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Host Long Noncoding RNAs as Key Players in Mycobacteria–Host Interactions

Microorganisms
Mycobacterial infections, caused by various species within the Mycobacterium genus, remain one of the main challenges to global health across the world.
Stephen K. Kotey, Xuejuan Tan, Audrey L. Kinser, Lin Liu, Yong Cheng   +4 more
doaj   +1 more source

Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment [PDF]

, 2010
PhDApproximately one-third of the global population is infected with tuberculosis causing approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect against TB, but it cannot prevent primary infection or reactivation of latent ...
Velji, Preya
core   +1 more source

Evaluation of nucleotide MALDI-TOF-MS for the identification of Mycobacterium species

Frontiers in Cellular and Infection Microbiology
BackgroundThe accurate identification of the Mycobacterium tuberculosis complex (MTBC) and different nontuberculous mycobacteria (NTM) species is crucial for the timely diagnosis of NTM infections and for reducing poor prognoses.
Yelei Zhu, Zhengwei Liu, Lina Peng, Bin Liu, Kunyang Wu, Mingwu Zhang, Xiaomeng Wang, Junhang Pan   +7 more
doaj   +1 more source

Cutaneous Rosai‐Dorfman Disease With MAP2K1 Mutation Treated With Encorafenib and Binimetinib

JEADV Clinical Practice, EarlyView.
ABSTRACT Rosai‐Dorfman disease (RDD) is a rare histiocytic disorder with unifocal to multisystemic involvement. Activating mutations in the MAPK/ERK pathway can occur in up to 50% of RDD cases. We report a case of cutaneous RDD (C‐RDD) with facial and truncal lesions harboring an activating MAP2K1 (MEK1) mutation that showed a complete response to a ...
Melike Ak, Reinhard Dummer, Egle Ramelyte   +2 more
wiley   +1 more source