Results 91 to 100 of about 1,040,351 (259)

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

Chemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak, Huy N. Hoang, Wael Awad, Xin Yi Lim, Damica D. Laurie, Ryan J. D. Rivero, James McCluskey, Alexandra J. Corbett, Jamie Rossjohn, David P. Fairlie   +9 more
wiley   +1 more source

Mycobacterium abscessus subspecies massiliense infection after skin graft and cholecystectomy in a burn patient

International Journal of Infectious Diseases, 2018
Diagnosing skin and soft tissue infections due to rapidly growing mycobacteria (RGM) can often prove difficult, leading to delays in treatment. Postoperative infections caused by RGM are increasingly recognized both within and outside the USA, but are ...
Nathan A. Summers, Russell Kempker, Federico Palacio   +2 more
doaj   +1 more source

Genetic characterization of Mycobacterium avium isolates recovered from humans and animals in Australia [PDF]

, 1996
Genetic relationships amongst 115 mainly Australian isolates of Mycobacterium avium were assessed using multilocus enzyme electrophoresis (MEE). The isolates were divided into 58 electrophoretic types (ETs), with a mean genetic diversity of 0·29 ...
Gilbert, G.L., Feizabadi, M.M., Dawson, D., Chew, W., Robertson, I.D., Cousins, D.V., Hampson, D.J.   +6 more
core  

Successful Translational Prediction of Bedaquiline's Phase 2a Clinical Trial Results against Tuberculosis: The Zebrafish as a New Approach Methodology

Clinical Pharmacology &Therapeutics, EarlyView.
Tuberculosis remains an urgent global health crisis that requires an accelerated development of novel regimens. Rodent and rabbit studies currently inform early translational predictions. However, the zebrafish (Danio rerio) embryo/larva, as a New Approach Methodology, provides an ethical, cost‐effective, and high‐throughput non‐mammalian disease model
Bart van Lieshout, Aanisah Hanuun, J. G. Coen van Hasselt, Rob C. van Wijk   +3 more
wiley   +1 more source

Mycobacterium avium-intracellulare brain abscess in HIV-positive patient

Annals of Indian Academy of Neurology, 2012
Mycobacterial opportunistic infections are a major cause of morbidity and mortality among patients living with HIV (PLHIV) worldwide. Nontuberculous mycobacterial (NTM) infection is one of the leading causes of opportunistic infection in patients with ...
Sampada S Karne, Shashikala A Sangle, Dilip S Kiyawat, Sujata N Dharmashale, Dilip B Kadam, Renu S Bhardwaj   +5 more
doaj   +1 more source

"Mycobacterium ulcerans" disease and treatment : a histopathological perspective [PDF]

, 2011
Summary: Buruli ulcer (BU) caused by Mycobacterium ulcerans is a chronic necrotizing skin disease with the highest prevalence in West-African countries.
Ruf, Marie-Thérèse
core   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Disseminated Mycobacterium Chelonae infection in an immunocompromised adult: An uncommon etiology of skin infection

IDCases
Mycobacterium Chelonae is a rapidly growing nontuberculous mycobacterium (NTM) that is ubiquitous in the environment and is associated with skin and soft tissue infections (1).
Biruk Amare, Andrew Mangano, Moumita Sarker, Sagun Adhikari   +3 more
doaj   +1 more source

A single-nucleotide-polymorphism real-time PCR assay for genotyping of mycobacterium tuberculosis complex in peri-urban Kampala [PDF]

, 2015
Accurate and high-throughput genotyping of Mycobacterium tuberculosis complex (MTBC) may be important for understanding the epidemiology and pathogenesis of tuberculosis (TB).
Eddie M. Wampande, Kathleen Eisenach, Mary Nsereko, Stavroula K. Hatzios, Wampande, Eddie M., Hatzios, Stavroula K., Mayanja, Harriet K., Mupere, Ezekiel, Gagneux, Sebastien, Eisenach, Kathleen, Joloba, Moses L., Moses L. Joloba, Achan, Beatrice, Ezekiel Mupere, Nsereko, Mary, Sebastien Gagneux, Harriet K. Mayanja, null null, Boom, W Henry, Boom, W. Henry, W Henry Boom, Tuberculosis Research Unit,, Beatrice Achan   +22 more
core   +2 more sources

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source