Results 61 to 70 of about 174,365 (247)

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression

BMC Microbiology, 2006
Background Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins.
Tayyebi Ali, Ashraf Mussarat, Hasan Zahra, Hussain Rabia   +3 more
doaj   +1 more source

Nitazoxanide is active against Mycobacterium leprae

PLoS ONE, 2017
Nitazoxanide (NTZ) is an anti-parasitic drug that also has activity against bacteria, including Mycobacterium tuberculosis. Our data using both radiorespirometry and live-dead staining in vitro demonstrate that NTZ similarly has bactericidal against M ...
M. Bailey, Han Na, M. Duthie, T. Gillis, R. Lahiri, T. Parish   +5 more
semanticscholar   +1 more source

Persistent Facial Nodules in an Elderly Patient

JEADV Clinical Practice, EarlyView.
Qian Ding, Qin‐Si Liu, Heng‐Guang Zhao   +2 more
wiley   +1 more source

Weight Loss‐Associated Remodeling of Adipose Tissue Immunometabolism

Obesity Reviews, Volume 26, Issue 12, December 2025.
ABSTRACT Obesity is a multifactorial condition characterized by excessive adiposity and systemic chronic low‐grade inflammation. Recent literature reflects a growing appreciation for the complex interplay between metabolism and the immune system in the pathogenesis of obesity‐related health conditions.
Paulo José Basso, Alejandro Schcolnik‐Cabrera, Mengyi Zhu, Erin Strachan, Xavier Clemente‐Casares, Sue Tsai   +5 more
wiley   +1 more source

Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia

PLoS Neglected Tropical Diseases, 2017
Leprosy in Colombia is in a stage of post elimination—since 1997, prevalence of the disease is less than 1/10000. However, the incidence of leprosy has remained stable, with 400–500 new cases reported annually, with MB leprosy representing 70% of these ...
M. Romero-Montoya, J. C. Beltrán-Alzate, N. Cardona-Castro   +2 more
semanticscholar   +1 more source

Widespread Skin Lesions in an Italian Man

JEADV Clinical Practice, EarlyView.
Rebecca Donadoni, Giulia Merlo, Gabriele Zanardi, Antonio Guadagno, Corrado Cabona, Stefania Artioli, Claudia Micalizzi, Emanuele Cozzani   +7 more
wiley   +1 more source

Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health

Journal of Applied Ecology, Volume 62, Issue 11, Page 2894-2913, November 2025.
Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley   +1 more source

The role of red squirrels in leprosy dynamics in the United Kingdom: a critical review

One Health
In the United Kingdom, the declining population of the red squirrel, the acknowledged historical reservoir for zoonotic Mycobacterium leprae leprosy, is thought to have been behind the decline in leprosy.
S. Souguel, T. Oueslati, G. Grine, M. Drancourt   +3 more
doaj   +1 more source

Vitamin D status contributes to the antimicrobial activity of macrophages against Mycobacterium leprae

PLoS Neglected Tropical Diseases, 2018
Background The immune system depends on effector pathways to eliminate invading pathogens from the host in vivo. Macrophages (MΦ) of the innate immune system are armed with vitamin D-dependent antimicrobial responses to kill intracellular microbes ...
Elliot W. Kim, Rosane M. B. Teles, Salem Haile, Philip T Liu, R. Modlin   +4 more
semanticscholar   +1 more source

On the age of leprosy. [PDF]

PLoS Neglected Tropical Diseases, 2014
Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. Human leprosy has been documented for millennia in ancient cultures. Recent genomic studies of worldwide M.
Xiang Y Han, Francisco J Silva
doaj   +1 more source