Results 61 to 70 of about 14,244 (229)
Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source
FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
The Activity of a Thiadiazole on Mycobacterium leprae
Experimental Biology and Medicine, 1976 SummaryA new broad-spectrum antimicrobial, 2-amino-5-(l-methyl-5-nitro-2-imi-dazolyl)-1,3,4-thiadiazole, reported inactive against Mycobacterium tuberculosis, inhibited multiplication of M. leprae in the mouse foot pad when administered orally to the mice.
openaire +3 more sources
PLoS Neglected Tropical Diseases, 2014 Leprosy is a chronic infection of the skin and nerves caused by Mycobacterium leprae and the newly discovered Mycobacterium lepromatosis. Human leprosy has been documented for millennia in ancient cultures. Recent genomic studies of worldwide M.
Xiang Y Han, Francisco J Silva
doaj +1 more source
Deciphering a Sleeping Pathogen: Uncovering Novel Transcriptional Regulators of Hypoxia-Induced Dormancy in Mycobacterium Tuberculosis [PDF]
arXiv, 2023 Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as latency. Affecting nearly two billion people, latent TB can linger in the host for indefinite periods of time ...
arxiv
Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon
Advanced Therapeutics, Volume 8, Issue 4, April 2025.Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap +10 more
wiley +1 more source
Studies of Lipoproteins of Mycobacterium leprae
Japanese journal of leprosy, 2004 The deciphering of the genomic sequence of Mycobacterium leprae has made possible to predict the possible lipoproteins. The consensus sequence at the N-terminal region of the protein, including the cysteine residue to which the lipid moiety gets attached, provides a clue to the search.
Yumi Maeda +2 more
openaire +3 more sources
Profiling of Intracellular Metabolites: An Approach to Understanding the Characteristic Physiology of Mycobacterium leprae. [PDF]
PLoS Neglected Tropical Diseases, 2016 Mycobacterium leprae is the causative agent of leprosy and also known to possess unique features such as inability to proliferate in vitro. Among the cellular components of M.
Yuji Miyamoto +5 more
doaj +1 more source
Green synthesis of silver nanoparticles using Curcuma longa flower extract and antibacterial activity [PDF]
arXiv, 2023 Silver nanoparticles (AgNP's) possess inherent biological potentials that have obliged an alternative, eco-friendly, sustainable approach to "Green Synthesis." In the present study, we synthesized Green Silver Nanoparticles (GAgNP's) using Curcuma longa L. (C. longa) flower extract as a reducing and capping agent.
arxiv
Anais Brasileiros de Dermatologia, 2016 Leprosy is a chronic infectious disease caused by Mycobacterium leprae. This bacillus has a high predilection for skin and peripheral nerves. The scalp’s anatomical properties do not favor the development of such mycobacterium.
Raila de Brito Macedo +4 more
doaj +1 more source