Results 61 to 70 of about 26,609 (224)

Skeletal Evidence for Leprosy in India by the Second Millenium B.C. [PDF]

, 2009
Leprosy is a chronic infectious disease caused by _Mycobacterium leprae_ that affects almost 500,000 people worldwide^1^. The timing of first infection, geographic origin, and pattern of transmission of the disease are unknown^1-3^.
Gwendolyn Robbins, Kelsey Gray, Malcolm Schug, RK Mohanty, Veena Tripathy, VN Misra, VS Shinde   +6 more
core   +1 more source

Lipid Body–Phagosome Interaction in Macrophages during Infectious Diseases: Host Defense or Pathogen Survival Strategy? [PDF]

, 2012
Phagocytosis of invading microorganisms by specialized cells such as macrophages and neutrophils is a key component of the innate immune response. These cells capture and engulf pathogens and subsequently destroy them in intracellular vacuoles—the ...
Dvorak, Ann Marie, Melo, Rossana C. N.
core   +2 more sources

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis.

PLoS Neglected Tropical Diseases, 2022
Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Timely detection is a challenge in leprosy diagnosis, relying on clinical examination and trained health professionals.
Fernanda Saloum de Neves Manta, Thiago Jacomasso, Rita de Cássia Pontello Rampazzo, Suelen Justo Maria Moreira, Najua M Zahra, Stewart T Cole, Charlotte Avanzi, Thyago Leal-Calvo, Sidra Ezidio Gonçalves Vasconcellos, Phillip Suffys, Marcelo Ribeiro-Alves, Marco Aurelio Krieger, Alexandre Dias Tavares Costa, Milton Ozório Moraes   +13 more
doaj   +1 more source

MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models [PDF]

, 2012
Comparative metabolic modelling is emerging as a novel field, supported by the development of reliable and standardized approaches for constructing genome-scale metabolic models in high throughput.
A Freitag, A Gevorgyan, A Mithani, Albert Gevorgyan, AM Feist, AM Feist, AM Feist, Andrzej M. Kierzek, AP Burgard, BA Pfeifer, CS Henry, D Nagrath, DC Alexander, DC Stevens, EM Paradise, Eriko Takano, FC Lee, H Ikeda, I Thiele, J Gonzalez-Lergier, J Romero, J Schellenberger, JD Orth, JL Adrio, JP Brooks, JS Edwards, K Nieselt, K Yanai, LM Blank, M DeJongh, M Durot, M Kanehisa, M Latendresse, MA Fischbach, MA Oberhardt, MA Oberhardt, MA Oberhardt, Marnix H. Medema, MH Medema, MH Medema, MH Medema, MH Medema, MT Alam, MT Alam, MW Covert, N Scherr, ND Price, ND Price, NE Lewis, Piotr Zakrzewski, PR Ives, R Breitling, R Schuetz, Rainer Breitling, SA Becker, SD Bentley, Stephen S. Fong, TD Vo, TY Kim, XQ Zhao   +59 more
core   +6 more sources

Clinico‐Epidemiological and Molecular Evidences for Reactivation of Herpesviruses in Dapsone‐Induced Hypersensitivity Reactions in Nepalese Leprosy Patients: An Observational Study

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
This study found clinical and molecular evidences for the presence of herpesvirus (HHV‐5 and HHV‐6) reactivation during dapsone‐induced hypersensitivity in Nepalese leprosy patients. Reflare of hypersensitivity symptoms occurred on average 20 days after culprit drug cessation.
Divya RSJB Rana, Jivan Shakya, Suwash Baral, Reejana Shrestha, Kishor Koju, Jarina Joshi, Deanna A. Hagge, Mahesh Shah   +7 more
wiley   +1 more source

Evidence for symmetric chromosomal inversions around the replication origin in bacteria. [PDF]

, 2000
BackgroundWhole-genome comparisons can provide great insight into many aspects of biology. Until recently, however, comparisons were mainly possible only between distantly related species.
Eisen, JA, Heidelberg, JF, Salzberg, SL, White, O   +3 more
core   +1 more source

Diagnostic assays for leprosy based on T-cell epitopes. [PDF]

, 2000
To date, only a limited number of antigens have been described as specific for Mycobacterium leprae, and in many cases, homologues have subsequently been shown to exist in mycobacteria such as M. avium and M. intracellulare.
Brahmbhatt, S, Britton, S, Dockrell, H M, Fruth, U, Gebre, N, Hunegnaw, M, Hussain, R, Manadhar, R, Murrillo, L, Pessolani, M C, Robertson, B D, Roche, P, Salgado, J L, Sampaio, E, Shahid, F, Thole, J E, Young, D B   +16 more
core   +1 more source

Coexistence of Scrofuloderma and Lepromatous Leprosy in Reaction: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Leprosy and tuberculosis (TB) are both chronic granulomatous infections caused by bacilli of the genus Mycobacterium. The simultaneous occurrence of cutaneous tuberculosis and leprosy is rare. We report a 56‐year‐old male presenting with painful erythematous nodules and plaques over the face and extremities for 1 week, along with asymptomatic ...
Anupa Khadka, Punam Mishra, Akanshya Shrestha, Gunawati Chaulagain   +3 more
wiley   +1 more source

The role of red squirrels in leprosy dynamics in the United Kingdom: a critical review

One Health
In the United Kingdom, the declining population of the red squirrel, the acknowledged historical reservoir for zoonotic Mycobacterium leprae leprosy, is thought to have been behind the decline in leprosy.
S. Souguel, T. Oueslati, G. Grine, M. Drancourt   +3 more
doaj   +1 more source

Our Impressive Immune System: More Than a Defense [PDF]

, 2014
Most likely the immune system was put into place in the original human body design. We know from Exodus 20:11 and other verses that God completed His work of creation in six days.
Conrad, Jason, Gillen, Alan L.
core   +1 more source