Results 51 to 60 of about 11,852 (180)

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression

BMC Microbiology, 2006
Background Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins.
Tayyebi Ali, Ashraf Mussarat, Hasan Zahra, Hussain Rabia   +3 more
doaj   +1 more source

Perceptions of Hansen's Disease in Northeast Brazil: A Community‐Based Study Integrating Stigma, Empowerment, and Social Distance

Tropical Medicine &International Health, Volume 31, Issue 4, Page 465-480, April 2026.
ABSTRACT Perceptions of Hansen’s disease (HD) can influence the level of stigma, empowerment, and intention to distance oneself from those affected by the disease. Knowledge, attitudes, and beliefs shape these perceptions. This study aims to understand perceptions of HD regarding stigma and empowerment. Method: A cross‐sectional, mixed‐methods research
Jaqueline Caracas Barbosa, Aymée Medeiros da Rocha, Hellen Xavier Oliveira, Nágila Nathaly Lima Ferreira, Adriana da Silva dos Reis, Anderson Fuentes Ferreira, Wim H. van Brakel, Anna T. van ‘t Noordende, Duane Charles Hinders, José Alexandre Menezes da Silva, Carmem Emmanuely Leitão Araújo, Rômulo do Nascimento Rocha, Alberto Novaes Ramos Jr   +12 more
wiley   +1 more source

Ausgeprägte und disseminierte atypische Mykobakteriose der Haut unter Immunsuppression

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 806-809, June 2026.
Veronika Zenderowski, Laura Schreieder, Mark Berneburg, Dennis Niebel, Sebastian Haferkamp, Sigrid Karrer, Konstantin Drexler   +6 more
wiley   +1 more source

A Multiepitope‐Based Lateral Flow Assay for Leprosy Antibodies

Analysis &Sensing, Volume 6, Issue 2, March 2026.
An innovative lateral flow assay for leprosy diagnosis is based on gold nanoparticles and synthetic Mycobacterium leprae epitopes conjugated to keyhole limpet hemocyanin protein to enhance antibody detection. This strategy provides a rapid, accurate, and low‐cost approach for resource‐limited settings, enabling the early detection of infection. Leprosy
Cristiane Zocatelli‐Ribeiro, Camila dos Anjos Proença, Ana Carolina da Rosa Nogarolli, Ana Fabiele Domakoski Trevisan, Thiago Neves Machado, João Carlos Degraf Muzzi, Larissa Magalhães Alvarenga, Juliana de Moura   +7 more
wiley   +1 more source

The role of red squirrels in leprosy dynamics in the United Kingdom: a critical review

One Health
In the United Kingdom, the declining population of the red squirrel, the acknowledged historical reservoir for zoonotic Mycobacterium leprae leprosy, is thought to have been behind the decline in leprosy.
S. Souguel, T. Oueslati, G. Grine, M. Drancourt   +3 more
doaj   +1 more source

Severe and disseminated atypical mycobacteriosis of the skin under immunosuppression

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 6, Page 806-808, June 2026.
Veronika Zenderowski, Laura Schreieder, Mark Berneburg, Dennis Niebel, Sebastian Haferkamp, Sigrid Karrer, Konstantin Drexler   +6 more
wiley   +1 more source

Type 2 Lepra Reaction Following Antituberculosis Treatment Initiation in an Elderly Male With Coexisting Hansen's Disease: A Case Report

Respirology Case Reports, Volume 14, Issue 3, March 2026.
We report a case of a man developing erythema nodosum leprosum after initiating treatment for drug‐susceptible pulmonary tuberculosis. This highlights the importance of recognising concomitant leprosy in patients with tuberculosis since these mycobacterial infections require different long‐term multidrug regimens.
Cary Amiel G. Villanueva, Ysabel Regina H. Ortiz, Winlove P. Mojica, Albert B. Albay Jr   +3 more
wiley   +1 more source

Pyrimidine scavenging by Mycobacterium leprae [PDF]

FEMS Microbiology Letters, 1989
Mycobacterium leprae incorporated exogenously supplied pyrimidines as bases or nucleosides, but not as a nucleotide, into its nucleic acids. Notably, thymine was incorporated approximately 5 times more rapidly than thymidine by both suspensions of, or intracellular M. leprae.
openaire   +2 more sources

Clinico‐Epidemiological and Molecular Evidences for Reactivation of Herpesviruses in Dapsone‐Induced Hypersensitivity Reactions in Nepalese Leprosy Patients: An Observational Study

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
This study found clinical and molecular evidences for the presence of herpesvirus (HHV‐5 and HHV‐6) reactivation during dapsone‐induced hypersensitivity in Nepalese leprosy patients. Reflare of hypersensitivity symptoms occurred on average 20 days after culprit drug cessation.
Divya RSJB Rana, Jivan Shakya, Suwash Baral, Reejana Shrestha, Kishor Koju, Jarina Joshi, Deanna A. Hagge, Mahesh Shah   +7 more
wiley   +1 more source