Results 41 to 50 of about 12,505 (136)

Synthetic Ligands of Myeloid C‐Type Lectin Receptors

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Binding of ligands to C‐type lectin receptors (CLRs) on myeloid cells can lead to an array of cellular responses. Exploitation of these receptors for therapeutic purposes requires high‐affinity ligands. This review surveys the diversity of synthetic ligands of myeloid CLRs in the context of binding, signaling, and downstream effects, as well as ...
James Suri, Bernd Lepenies
wiley   +1 more source

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy

Frontiers in Microbiology, 2022
The initial infection by the obligate intracellular bacillus Mycobacterium leprae evolves to leprosy in a small subset of the infected individuals. Transmission is believed to occur mainly by exposure to bacilli present in aerosols expelled by infected ...
Natasha Cabral, Vilma de Figueiredo, Mariana Gandini, Cíntia Fernandes de Souza, Rychelle Affonso Medeiros, Letícia Miranda Santos Lery, Flávio Alves Lara, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Geraldo Moura Batista Pereira   +9 more
doaj   +1 more source

Cutaneous Mycobacterium haemophilum Infection in an Immunosuppressed Host: A Case Report of Diagnostic Considerations and Microbiologic Confirmation

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Cutaneous Mycobacterium haemophilum infection may be missed due to its requirement for iron supplementation and low‐temperature incubation, making early consideration of NTM infection and use of molecular diagnostics essential, particularly in immunocompromised hosts where IRIS may mimic disease progression.
Angus Lane, Amanda Godbolt, Sarah Morton, Heather Wiseby, Vivek Menon, Chris Coulter, Sushil Pandey, Andrew Burke   +7 more
wiley   +1 more source

De Novo Histoid Leprosy Mimicking Xanthoma Disseminatum in a Malawian Male

Proceedings
Background: Leprosy is a chronic infection caused by Mycobacterium leprae and Mycobacterium lepromatosis with protean mucocutaneous manifestations [...]
Agnes Ramadimetja Sema-Ramashala, Ramolapo Antony Molapo   +1 more
doaj   +1 more source

Unveiling Saint Theobald: A Multidisciplinary Bioanthropological Investigation

International Journal of Osteoarchaeology, Volume 36, Issue 4, Page 945-953, July/August 2026.
ABSTRACT Saint Theobald of Provins (1033–1066), a French nobleman who embraced voluntary poverty, hermitism, and pilgrimage, represents an early figure in the medieval ascetic movement. He holds historical significance for the diffusion of 11th‐century ascetic ideals, as a hermit saint associated with the Camaldolese order and venerated across northern
Nicola Carrara, Cicero Moraes, Luca Bezzi, Alberto Zanatta, Luca Pagani, Gilberto Artioli, Cinzia Scaggion   +6 more
wiley   +1 more source

Development and validation of a multiplex real-time qPCR assay using GMP-grade reagents for leprosy diagnosis.

PLoS Neglected Tropical Diseases, 2022
Leprosy is a chronic dermato-neurological disease caused by Mycobacterium leprae, an obligate intracellular bacterium. Timely detection is a challenge in leprosy diagnosis, relying on clinical examination and trained health professionals.
Fernanda Saloum de Neves Manta, Thiago Jacomasso, Rita de Cássia Pontello Rampazzo, Suelen Justo Maria Moreira, Najua M Zahra, Stewart T Cole, Charlotte Avanzi, Thyago Leal-Calvo, Sidra Ezidio Gonçalves Vasconcellos, Phillip Suffys, Marcelo Ribeiro-Alves, Marco Aurelio Krieger, Alexandre Dias Tavares Costa, Milton Ozório Moraes   +13 more
doaj   +1 more source

Third Generation Genome Sequencing of the Endobacterium Corynebacterium kroppenstedtii subsp. demodicis Reveals Details of Its Microbe‐Host‐Interaction With the Most Complex Human Commensal, Demodex folliculorum

Environmental Microbiology Reports, Volume 18, Issue 3, June 2026.
The symbiotic interaction between Demodex folliculorum and Corynebacterium kroppenstedtii subsp. demodicis. Created by the author based on genomic and functional analyses presented in this work. The tripartite interaction between the human host, the mite Demodex folliculorum, and its endosymbiont Corynebacterium kroppenstedtii subsp. demodicis.
T. Steegmüller, S. Walch, S. Gschwendtner, A. Klingl, L. E. French, M. Flaig, B. M. Clanner‐Engelshofen   +6 more
wiley   +1 more source

M. leprae inhibits apoptosis in THP-1 cells by downregulation of Bad and Bak and upregulation of Mcl-1 gene expression

BMC Microbiology, 2006
Background Virulent Mycobacterium leprae interfere with host defense mechanisms such as cytokine activation and apoptosis. The mitochondrial pathway of apoptosis is regulated by the Bcl-2 family of proteins.
Tayyebi Ali, Ashraf Mussarat, Hasan Zahra, Hussain Rabia   +3 more
doaj   +1 more source

The role of red squirrels in leprosy dynamics in the United Kingdom: a critical review

One Health
In the United Kingdom, the declining population of the red squirrel, the acknowledged historical reservoir for zoonotic Mycobacterium leprae leprosy, is thought to have been behind the decline in leprosy.
S. Souguel, T. Oueslati, G. Grine, M. Drancourt   +3 more
doaj   +1 more source

Neurovascular–metabolic dysregulation, metabolic connectomics, and metabolic functional changes in Alzheimer's disease: A preclinical and clinical comparison

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Historically, imaging diagnostics in Alzheimer's disease (AD) have focused primarily on amyloid and tau accumulation; however, recent work suggests that neurometabolic and vascular dysregulation (MVD) may precede protein deposition and persist throughout the disease spectrum, preclinically and clinically.
Juan Antonio K. Chong Chie, Scott A. Persohn, Olivia R. Simcox, Alyssa Collins, Paul Salama, Paul R. Territo, for the Alzheimer's Disease Neuroimaging Initiative and MODEL‐AD consortium   +6 more
wiley   +1 more source