Results 111 to 120 of about 462,704 (302)

Construction of a severely attenuated mutant of Mycobacterium tuberculosis for reducing risk to laboratory workers

, 2008
The ability to construct defined deletions of Mycobacterium tuberculosis has allowed many genes involved in virulence to be identified. Deletion of nutritional genes leads to varying levels of attenuation, presumably reflecting the need for a particular ...
Williams, A, Williams, Ann, Clark, S, Clark, Simon, Smith, D, Hatch, Graham, Movahedzadeh, F, Stoker, N G, Movahedzadeh, Farahnaz, Bacon, Joanna, Parish, T, LSHTM, Ten Bokum, A M C, Parish, Tanya, Hatch, G, Smith, Debbie, HPA, Bacon, J, ten Bokum, Annemieke, Stoker, Neil   +19 more
core   +1 more source

Widespread occurrence of Mycobacterium tuberculosis DNA from 18th-19th century Hungarians [PDF]

, 2003
A large number (265) of burials from 1731-1838 were discovered in sealed crypts of the Dominican Church, Vac, Hungary in 1994. Many bodies were naturally mummified, so that both soft tissues and bones were available.
Spigelman, M, Spigelman, Mark, Holton, John, Pap, I, Fletcher, Helen A, Pap, Ildikó, Holton, J, Donoghue, HD, Donoghue, Helen D, Fletcher, Helen, Fletcher, HA   +10 more
core   +1 more source

Clinical Images: A thorn injury, a sea‐borne culprit, and a tenosynovitis dilemma

Arthritis &Rheumatology, EarlyView.
Jacopo Ciaffi, Francesco Mori, Paolo Sassu, Marco Gambarotti, Alberto Righi, Eleonora Zamparini, Marco Innocenti, Marina Tadolini, Francesco Ursini   +8 more
wiley   +1 more source

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, EarlyView.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Multiple drug-susceptibility screening in Mycobacterium bovis: new nucleotide polymorphisms in the embB gene among ethambutol susceptible strains

International Journal of Infectious Diseases, 2015
Objectives: Pyrazinamide-resistant Mycobacterium bovis isolates of animal origin were assessed for drug susceptibility to five antituberculosis drugs by the agar based Middlebrook 7H11 method as gold standard as well as by a simplified, dichotomous ...
Cinzia Marianelli, Federica Armas, Maria Beatrice Boniotti, Piera Mazzone, Maria Lodovica Pacciarini, Vincenzo Di Marco Lo Presti   +5 more
doaj   +1 more source

Mapping the fitness of Mycobacterium tuberculosis strains: a complex picture.

, 2010
Acquisition of antibiotic resistance in Mycobacterium tuberculosis has been shown to incur a fitness cost; the size of which depends on the position and nature of the mutation. The frequency at which resistant M. tuberculosis strains are isolated in vivo
Gillespie, S. H., O'Sullivan, DM, T. D. McHugh, McHugh, TD, S. H. Gillespie, Gillespie, SH, O'Sullivan, D. M., McHugh, T. D., D. M. O'Sullivan   +8 more
core   +1 more source

Production of recombinant human granulocyte‐macrophage colony‐stimulating factor in thermoinducible E. coli: Tuning inclusion body architecture and protein yield via dissolved oxygen control

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Recombinant protein expression in Escherichia coli frequently results in the formation of inclusion bodies (IBs), which provide high protein accumulation but often require additional steps to recover functional protein. Although culture conditions strongly influence IB physicochemical and structural characteristics, the impact of ...
Ximena Gómez‐Gil, Norma A Valdez‐Cruz, Sara Restrepo‐Pineda, Nuria Sánchez‐Puig, Rafael Vázquez‐Duhalt, Rubén D Cadena‐Nava, Néstor O Pérez, Mauricio A Trujillo‐Roldán   +7 more
wiley   +1 more source

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils.

, 2012
Neutrophils enter sites of infection, where they can eliminate pathogenic bacteria in an oxidative manner. Despite their predominance in active tuberculosis lesions, the function of neutrophils in this important human infection is still highly ...
Ronnie Chee, Corleis, Björn, Daniel Korbel, Robert Wilson, Chee, Ronnie, Bylund, Johan,, Johan Bylund, Wilson, Robert, Björn Corleis, Ulrich E. Schaible, Korbel, Daniel, Schaible, Ulrich E, Bylund, Johan   +12 more
core   +1 more source

Retrospective study of 668 cultures for mycobacteria in a reference hospital for AIDS in Southern Brazil

Brazilian Journal of Infectious Diseases
Although AIDS patients in other countries are frequently diagnosed as having atypical mycobacterial infection, in Southern Brazil there is a clinical impression that Mycobacterium tuberculosis is the rule rather than the exception.
Alessandro Comarú Pasqualotto, Daniela Dornelles Rosa, Maria do Carmo Fontoura Pereira, Roberto L. Targa-Ferreira, Breno Riegel Santos   +4 more
doaj   +1 more source