Results 141 to 150 of about 843,867 (389)

Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections

Chemistry &Biodiversity, EarlyView.
ABSTRACT Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the clinical properties of Varronia curassavica Jacq. are highlighted due to its biological and pharmacological activities.
José Thyálisson da Costa Silva, Gabriel Gonçalves Alencar, Nara Juliana Santos Araújo, Lariza Leisla Leandro Nascimento, Saulo Almeida Menezes, Dhenes Ferreira Antunes, Adrielle Rodrigues Costa, Murilo Felipe Felício, Cicero dos Santos Leandro, Luis Pereira de Morais, Marcos Aurélio Figueirêdo dos Santos, Severino Denicio Gonçalves de Sousa, Julimery Gonçalves Ferreira Macedo, João Pereira da Silva Junior, Ana Carolina Ferreira Araujo, Maísa Freire Cartaxo Pires de Sá, Jacqueline Cosmo Andrade‐Pinheiro, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra   +18 more
wiley   +1 more source

Characterization of water and wildlife strains as a subgroup of Campylobacter jejuni using DNA microarrays.

, 2013
Campylobacter jejuni is the leading cause of human bacterial gastroenteritis worldwide, but source attribution of the organism is difficult. Previously, DNA microarrays were used to investigate isolate source, which suggested a non-livestock source of ...
Altschul, Brandl, Champion, Dingle, Dingle, Dorrell, Ethelberg, Francisco, French, Gundogdu, Harris, Hepworth, Hepworth, Hinchliffe, Howard, Huelsenbeck, Jensen, Jorgensen, Joshua, Kalendar, Karenlampi, Katoh, Katoh, Kemp, Kim, Kim, King, Kwan, Kwan, Manning, McCarthy, Mellmann, Miller, Moen, Murphy, Ogden, On, Park, Pearson, Petersen, Ronquist, Rosef, Rosef, Sails, Sanad, Schonberg-Norio, Skirrow, Skirrow, Stabler, Staden, Staden, Taboada, Taboada, Tam, Tam, Wilson   +55 more
core   +1 more source

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]

, 2018
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika, Karaś, Magdalena, Lipa, Paulina, Vinardell González, José María   +3 more
core   +1 more source

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection

PLoS Pathogens, 2016
While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear.
Pushpa Jayaraman, M. Jacques, Chen Zhu, Katherine M. Steblenko, Britni L. Stowell, A. Madi, A. Anderson, V. Kuchroo, S. Behar   +8 more
semanticscholar   +1 more source

Antibacterial and Antibiofilm Activity of 8‐Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species

Chemistry &Biodiversity, EarlyView.
Synthesis of 8‐hydroxyquinoline derivatives (QD 1‐12) from different analogues of 8‐hydroxyquinoline (HQ 1‐4). The derivatives and parent compounds were evaluated for antibacterial and antibiofilm activity against Mycobacterium tuberculosis, Mycobacterium smegmatis, methicillin‐resistant Staphylococcus aureus and methicillin‐sensitive Staphylococcus ...
Namrita Lall, Anna‐Mari Kok, Carel B. Oosthuizen, Surjeet Verma, François Chassagne, Phuc H. Vo, Khanh‐Van Ho, Chung‐Ho Lin, Cassandra L. Quave, Danielle Twilley   +9 more
wiley   +1 more source

Genomic analysis of Mycobacterium bovis and other members of the Mycobacterium tuberculosis complex by isoenzyme analysis and pulsed-field gel electrophoresis. [PDF]

, 1996
Initially, multilocus enzyme electrophoresis was used to examine genetic relationships among 63 isolates of Mycobacterium bovis and 13 other members of the M. tuberculosis complex.
Cousins, D.V., Feizabadi, M.M., Hampson, D.J., Robertson, I.D.   +3 more
core   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment [PDF]

, 2003
Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric ...
Butcher, PD, Dolganov, G, Efron, B, Ehrt, S, Liu, Y, Mangan, JA, Monahan, IM, Nathan, C, Schnappinger, D, Schoolnik, GK, Voskuil, MI   +10 more
core   +3 more sources

Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo

Journal of Experimental Medicine, 2016
Russell et al. show that activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Yancheng Liu, Shumin Tan, Lu Huang, R. Abramovitch, K. Rohde, M. Zimmerman, Chao Chen, V. Dartois, B. VanderVen, D. Russell   +9 more
semanticscholar   +1 more source

Synthesis and Evaluation of Trehalose‐Based Mertansine Warheads for Bacillus Calmette–Guérin Delivery of Anticancer Agents

ChemBioChem, EarlyView.
Bacillus Calmette–Guérin (BCG) immunotherapy is the gold standard for nonmuscle invasive bladder cancer (NMIBC). However, it is limited by adverse effects and resistance, despite eliciting a robust immune response. This proof‐of‐concept study explores Antigen 85‐mediated, metabolically with trehalose‐PEG4 mertansine‐labeled BCG as a novel treatment ...
Michael Grimmeisen, Xuan Wang, Melissa Weldle, Kerstin Sartory, Sara Benkhelifa, Yu Zhang, Trinh Dao, Jonas Meyer, Oliver Gorka, Olaf Groß, Claudia Jessen‐Trefzer   +10 more
wiley   +1 more source