Results 221 to 230 of about 843,867 (389)

Lipid regulation of adenylyl cyclase Rv1625c from Mycobacterium tuberculosis by its membrane‐domain receptor

open access: yesThe FEBS Journal, EarlyView.
The adenylyl cyclase (AC) Rv1625c from M. tuberculosis is a monomeric progenitor of the nine pseudoheterodimeric mammalian AC isoforms. The hexahelical membrane anchor of Rv1625c serves as an inhibitory receptor for fatty acids, particularly oleic acid. One ligand binds into each monomer of the active Rv1625c dimer.
Anita Charlotte Friderun Schultz   +3 more
wiley   +1 more source

Genomic epidemiology of Mycobacterium tuberculosis in Wales. [PDF]

open access: yesSci Rep
Pacchiarini N   +11 more
europepmc   +1 more source

Mechanism of cyanobacterial ferredoxin‐dependent flavin thioredoxin reductase reveals thiolate‐FAD charge transfer and catalytic asymmetry in a homodimer

open access: yesThe FEBS Journal, EarlyView.
Ferredoxin‐dependent flavin thioredoxin reductases (FFTRs) regenerate reduced thioredoxin, sustaining dithiol–disulfide exchange reactions that regulate protein activity in select organisms. In cyanobacterial FFTRs, we describe the formation of a thiolate–flavin charge transfer complex, asynchronous reduction of the two FAD cofactors within the ...
Martha Minjarez‐Saenz   +8 more
wiley   +1 more source

Tibial osteitis caused by Mycobacterium tuberculosis. [PDF]

open access: yesAccess Microbiol
Benjelloun M   +4 more
europepmc   +1 more source

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

open access: yesThe FEBS Journal, EarlyView.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis   +2 more
wiley   +1 more source

Stigma, depression and pillbox return among adults living with HIV in rural Tanzania: A prospective cohort study

open access: yesHIV Medicine, EarlyView.
Abstract Background Stigma remains a major barrier to accessing HIV care. We analysed the association between stigma and failed pillbox return, and described factors associated with stigma among adults living with HIV in rural Tanzania. Methods From the Kilombero and Ulanga Antiretroviral Cohort we included newly diagnosed adults ≥15 years enrolled ...
Robert Ndege   +11 more
wiley   +1 more source

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