Results 51 to 60 of about 692,714 (305)

Aktivitas Anti Mycobacterium tuberculosis Strain H37Rv dan MDR (Multi Drug Resistant) dari Ekstrak Rimpang Curcuma mangga Val.

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy), 2020
TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga  rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug.
Ritha Pratiwi, Gemini Alam, Herlina Rante, Nasrum Massi   +3 more
doaj   +1 more source

IFN-γ independent immune markers of Mycobacterium tuberculosis exposure

Nature Medicine, 2019
Exposure to Mycobacterium tuberculosis (Mtb) results in heterogeneous clinical outcomes including primary progressive tuberculosis and latent Mtb infection (LTBI).
Lenette L. Lu, Lenette L. Lu, Malisa T. Smith, Krystle K. Q. Yu, Corinne Luedemann, T. Suscovich, Patricia S Grace, Adam Cain, Wen-Han Yu, Wen-Han Yu, T. McKitrick, D. Lauffenburger, R. Cummings, H. Mayanja-Kizza, T. Hawn, W. Boom, Catherine M. Stein, Sarah M. Fortune, Sarah M. Fortune, C. Seshadri, G. Alter   +20 more
semanticscholar   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Microbiology Spectrum
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after ...
Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase   +5 more
doaj   +1 more source

The molecular clock of Mycobacterium tuberculosis

bioRxiv, 2019
The molecular clock and its phylogenetic applications to genomic data have changed how we study and understand one of the major human pathogens, Mycobacterium tuberculosis (MTB), the causal agent of tuberculosis.
Fabrizio Menardo, S. Duchêne, D. Brites, S. Gagneux   +3 more
semanticscholar   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Risk factors, molecular analysis and treatment outcomes of amikacin-resistant Mycobacterium avium complex pulmonary disease

ERJ Open Research
Background Although the incidence of amikacin (AMK)-resistant Mycobacterium avium complex (MAC) pulmonary disease (PD) is suspected to have increased, limited data are available on AMK-resistant MAC-PD.
Tatsuya Kodama, Akio Aono, Keiji Fujiwara, Koji Furuuchi, Masashi Ito, Keisuke Kamada, Fumiya Watanabe, Kinuyo Chikamatsu, Yuriko Igarashi, Yoshiro Murase, Hideo Ogata, Yuji Shiraishi, Takashi Yoshiyama, Ken Ohta, Satoshi Mitarai, Kozo Morimoto   +15 more
doaj   +1 more source

Xpert MTB/RIF Ultra for detection of Mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study

Lancet. Infectious Diseases (Print), 2018
Summary Background The Xpert MTB/RIF assay is an automated molecular test that has improved the detection of tuberculosis and rifampicin resistance, but its sensitivity is inadequate in patients with paucibacillary disease or HIV.
Susan E Dorman, S. Schumacher, David Alland, P. Nabeta, D. Armstrong, Bonnie S. King, S. L. Hall, S. Chakravorty, D. M. Cirillo, N. Tukvadze, N. Bablishvili, W. Stevens, L. Scott, Camilla Rodrigues, M. Kazi, Moses L. Joloba, L. Nakiyingi, M. Nicol, Y. Ghebrekristos, I. Anyango, W. Murithi, R. Dietze, Renata Lyrio Peres, A. Skrahina, Vera Auchynka, K. Chopra, M. Hanif, Xin Liu, Xing Yuan, C. Boehme, J. Ellner, Claudia M. Denkinger, Susan E Samuel G David Pamela Derek T Bonnie Sandra L So Dorman Schumacher Alland Nabeta Armstrong King Hal, Susan E Dorman, S. Schumacher, David Alland, P. Nabeta, D. Armstrong, Bonnie S. King, S. L. Hall, S. Chakravorty, D. M. Cirillo, N. Tukvadze, N. Bablishvili, W. Stevens, L. Scott, Camilla Rodrigues, M. Kazi, Moses L. Joloba, L. Nakiyingi, M. Nicol, Y. Ghebrekristos, I. Anyango, W. Murithi, R. Dietze, R. L. Peres, A. Skrahina, Vera Auchynka, K. Chopra, M. Hanif, Xin Liu, Xing Yuan, C. Boehme, J. Ellner, Claudia M. Denkinger, Y. Manabe, D. Hom, R. Aspindzelashvili, A. David, Utkarsha Surve, L. Kamulegeya, Sheila Nabweyambo, S. Surtie, N. Hapeela, K. Cain, J. Agaya, K. McCarthy, P. Marques-Rodrigues, Luiz Guilherme Schmidt Castellani, P. Almeida, Paola Poloni Lobo de Aguiar, V. Solodovnikova, Xianglin Ruan, L. Liang, Guolong Zhang, H. Zhu, Yingda L. Xie   +86 more
semanticscholar   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis

mBio, 2020
Mycobacterium tuberculosis, which causes tuberculosis (TB), is estimated to infect one-third of the world’s population. The overall burden and the emergence of drug-resistant strains of Mycobacterium tuberculosis underscore the need for new therapeutic ...
Jeffrey Quigley, Aaron Peoples, Asel Sarybaeva, Dallas Hughes, Meghan Ghiglieri, Catherine Achorn, Alysha Desrosiers, Cintia Felix, Libang Liang, Stephanie Malveira, William Millett, Anthony Nitti, Baldwin Tran, Ashley Zullo, Clemens Anklin, Amy Spoering, Losee Lucy Ling, Kim Lewis   +17 more
doaj   +1 more source