Results 61 to 70 of about 327,982 (244)

Different transcriptional profiles of RAW264.7 infected with Mycobacterium tuberculosis H37Rv and BCG identified via deep sequencing. [PDF]

PLoS ONE, 2012
BACKGROUND: The Mycobacterium tuberculosis H37Rv and BCG effects on the host cell transcriptional profile consider a main research point. In the present study the transcriptome profiling analysis of RAW264.7 either infected with Mycobacterium ...
Fengguang Pan, Yaya Zhao, Seng Zhu, Changjiang Sun, Liancheng Lei, Xin Feng, Wen Yu Han   +6 more
doaj   +1 more source

A robust SNP barcode for typing Mycobacterium tuberculosis complex strains [PDF]

, 2014
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance.
Glynn, Judith R., Clark, T.G., Perdigão, João, Judith R. Glynn, McNerney, R., McNerney, Ruth, Viveiros, M., Glynn, Judith R, Guerra-Assunção, José Afonso, Guerra-Assunção, J.A., Coll, Francesc, Viveiros, Miguel, Isabel Portugal, Clark, Taane G., Perdigão, J., Pain, A., Pain, Arnab, Glynn, J.R., Jose ́ Afonso Guerra-assunção, Portugal, I., Ruth Mcnerney, Miguel Viveiros, Francesc Coll, Portugal, Isabel, Martin, Nigel, Arnab Pain, Nigel Martin, Taane G. Clark, Coll, F., Clark, Taane G   +29 more
core   +1 more source

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules [PDF]

, 2009
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term coexistence of host and pathogen.
Donoghue, HD, Helen D. Donoghue
core   +1 more source

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

Advanced Science, EarlyView.
Single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq) integrates cell‐associated bacterial 16S‐derived signals with host transcriptomes to resolve bacterial signal‐enriched myeloid states in Klebsiella pneumoniae sepsis. Complementary pharmacological and genetic analyses define a CD38–NAD immunometabolic axis connecting mitochondrial bioenergetic ...
Yangguang Li, Yilong Yu, Fang Qin, Shenxing Li, Xuanheng Li, Peizhao Liu, Juanhan Liu, Haiqing Liu, Songqi Jing, Jianghao Zou, Sicheng Li, Jiayang Li, Tao Zheng, Yun Zhao, Jianan Ren, Xiuwen Wu   +15 more
wiley   +1 more source

Alarming levels of fluoroquinolone resistance among MDR-TB patients in Poland: molecular and phenotypic analysis

Frontiers in Cellular and Infection Microbiology
BackgroundFluoroquinolones (FQs) are a cornerstone of modern multidrug-resistant tuberculosis (MDR-TB) treatment, particularly within the WHO-recommended all-oral BPaLM regimen.
Monika Kozińska, Agnieszka Głogowska, Alina Minias, Jarosław Dziadek, Ewa Augustynowicz-Kopeć   +4 more
doaj   +1 more source

Pervasive Translation in Mycobacterium tuberculosis [PDF]

eLife, 2019
ABSTRACT Most bacterial ORFs are identified by automated prediction algorithms. However, these algorithms often fail to identify ORFs lacking canonical features such as a length of >50 codons or the presence of an upstream Shine-Dalgarno sequence.
Archer J Wang, Jill G Canestrari, Carol Smith, Matthew M Champion, Keith M Derbyshire, Todd A Gray, Joseph T Wade   +6 more
openaire   +3 more sources

In situ PCR for Mycobacterium tuberculosis in endoscopic mucosal biopsy specimens of intestinal tuberculosis and Crohn disease [PDF]

, 2008
Tuberculosis and Crohn disease are granulomatous disorders affecting the intestinal tract with similar clinical manifestations and pathologic features.
Pulimood, AB, Rook, GWA, Peter, S, Donoghue, HD   +3 more
core  

Spatially Confined/Ligand‐Directed Ultrabright NIR‐AIE Nanoprobe for In Vitro Rapid Detection and In Situ Imaging of Bacterial Septic Arthritis

Advanced Science, EarlyView.
Inorganic PbS quantum dots spatially confine AIEgens and enable cooperative luminescence within a ligand‐directed core–shell–shell nanoassembly, generating ultrabright NIR PPANPs with enhanced fluorescence and photothermal performance. The platform enables 10‐min S.
Yujian Li, Jia Shu, Sijia Lv, Leilei Qin, Xuefeng Luo, PengCheng Xiao, Huan Cai, Xin Gao, Yan Zhao, Haotian Zhou, Yaji Yang, Zhenglin Zhu, Shijia Ding, Juan Li, Rui Chen, Wei Huang   +15 more
wiley   +1 more source