Results 81 to 90 of about 327,982 (244)

Rifampicin resistance in tuberculosis outbreak, London, England [PDF]

, 2005
Mycobacterium tuberculosis isolates cultured from 6 patients associated with an isoniazid-resistant M. tuberculosis outbreak acquired rifampicin resistance. The rpoB gene sequence showed that resistance was associated with rare mutations in each isolate.
Shorten, R J, McHugh, TD, Claxton, A P, Claxton, AP, Mary Jo Knobloch, Gillespie, S H, Claire Jenkins, Stephen H. Gillespie, Shorten, RJ, McHugh, T D, Edward A. Belongia, Richard E. Besser, Timothy D. McHugh, Robert J. Shorten, Burney A. Kieke, Carolyn Janette, Gillespie, SH, Jeffrey P. Davis, Jenkins, C, Alleyna P. Claxton, Gillespie, S H ; id_orcid   +20 more
core   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

Escape of Mycobacterium tuberculosis from oxidative killing by neutrophils.

, 2012
Neutrophils enter sites of infection, where they can eliminate pathogenic bacteria in an oxidative manner. Despite their predominance in active tuberculosis lesions, the function of neutrophils in this important human infection is still highly ...
Ronnie Chee, Corleis, Björn, Daniel Korbel, Robert Wilson, Chee, Ronnie, Bylund, Johan,, Johan Bylund, Wilson, Robert, Björn Corleis, Ulrich E. Schaible, Korbel, Daniel, Schaible, Ulrich E, Bylund, Johan   +12 more
core   +1 more source

Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection [PDF]

, 2011
The aim of this project was to compare the breadth and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T ...
Moshi, Noell Dominika
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

Molecular epidemiological analysis of Mycobacterium tuberculosis isolates from rural population of nationwide tuberculosis prevalence survey in Mongolia

Central Asian Journal of Medical Sciences
Objective: Mongolia is among the 30 high-burden countries for TB and DR-TB. Whole-genome sequencing (WGS) offers precise insights into TB transmission, strain diversity, and antimicrobial resistance (AMR), which are vital for TB control strategies.
Oyuntuya Tumenbayar, Tsolmon Boldoo, Yoshiro Murase, Tsetsegtuya Borolzoi, Naranzul Dambaa, Tugsdelger Sovd, Naranbat Nyamdavaa, Satoshi Mitarai, Buyankhishig Burneebaatar, Sarantuya Jav   +9 more
doaj   +1 more source

Thiamine Diphosphate‐Dependent Biocatalysis in the 21st Century

Chemistry – A European Journal, EarlyView.
This account summarizes the major discoveries and recent advances, highlighting the biocatalytic abilities, mechanistic studies, and feature‐based classification that are shaping emerging perspectives on thiamine diphosphate (ThDP)‐dependent catalysis.
Lucrezia Lanza, Daniela Bjarnesen, Michael Müller   +2 more
wiley   +1 more source

Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]

, 2012
There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.
Coscollà Mireia, David Stucki, Feldmann, Julia, Yeboah-Manu, D., Comas Iñaki, Gagneux, Sebastien, Hostettler Simon, Simon Hostettler, Thembela Huna (149818), Huna, Thembela, Huna Thembela, Malla Bijaya, Mireia Coscollà, Julia Feldmann (149820), Feldmann Julia, Stucki, David, Iñaki Comas (57109), Thembela Huna, Hostettler, S., Comas, Iñaki, Malla, Bijaya, Stucki David, Dorothy Yeboah-Manu, Sonia Borrell, David Stucki (149811), Huna, T., Gagneux, S., Yeboah-Manu, Dorothy, Fenner, Lukas, Borrell, Sonia, Dorothy Yeboah-Manu (120059), Comas, I., Bijaya Malla, Gagneux Sebastien, Fenner, L., Borrell Sonia, Hostettler, Simon, Lukas Fenner, Fenner Lukas, Bijaya Malla (149813), Sebastien Gagneux (149824), Mireia Coscollà (149823), Coscollà, Mireia, Sebastien Gagneux, Malla, B., Simon Hostettler (149816), Sonia Borrell (149821), Borrell, S., Julia Feldmann, Coscolla, M., Yeboah-Manu Dorothy, Lukas Fenner (149822), Iñaki Comas, Feldmann, J., Stucki, D., Hostettler S, Fenner L, Yeboah-Manu D, Gagneux S, Huna T, Feldmann J, Borrell S, Malla B, Comas I, Stucki D, Coscollà M   +65 more
core   +3 more sources