Results 81 to 90 of about 692,714 (305)

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

open access: yesAdvanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang   +19 more
wiley   +1 more source

Polisakarida Krestin dari Jamur Coriolus versicolor terhadap hitung Jenis Leukosit Mencit yang diinfeksi Mycobacterium tuberculosis

open access: yesBiotropic: The Journal of Tropical Biology, 2017
Penelitian ini bertujuan untuk mengetahui peran polisakarida krestin (PSK) dengan waktu pemberian yang berbeda terhadap hitung jenis leukosit mencit yang diinfeksi Mycobacterium tuberculosis.
Risa Purnamasari
doaj   +1 more source

Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human Diseases

open access: yesFrontiers in Cellular and Infection Microbiology, 2018
Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), is an extremely successful pathogen that adapts to survive within the host. During the latency phase of infection, M.
Qiyao Chai, Yong Zhang, C. Liu
semanticscholar   +1 more source

THE BIOLOGY OF MYCOBACTERIUM TUBERCULOSIS INFECTION.

open access: yesMediterranean Journal of Hematology and Infectious Diseases, 2013
Tuberculosis (TB) still poses a major threat to mankind and during the last thirty years we have seen a recrudescence of the disease even in countries where TB was thought to be conquered. It is common opinion that more effective control tools such as new diagnostics, a new vaccine and new drugs are urgently needed to control the global pandemic ...
Delogu, Giovanni   +2 more
openaire   +6 more sources

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Children and Mycobacterium tuberculosis: a review of susceptibility and protection

open access: yesLancet. Infectious Diseases (Print), 2018
Unstructured summary Children represent both a clinically important population susceptible to tuberculosis, but also a key group in whom to study intrinsic and vaccine-induced mechanisms of protection.
R. B. Roy   +3 more
semanticscholar   +1 more source

Mycobacterium tuberculosis pyomyositis in an infant

open access: yesAnnals of Medical and Health Sciences Research, 2013
Mycobacterium tuberculosis is endemic to many parts of the world. It may have variable clinical presentations, especially in the pediatric age group. Presented here is the case of a 9-month old infant who was referred for infectious disease opinion when his thigh induration failed to improve after surgical drainage and a course of oral antibiotic ...
Malik, ZA, Shehab, M
openaire   +3 more sources

Consumed by Abdominal Distention

open access: yes
Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge   +3 more
wiley   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo   +3 more
wiley   +1 more source

Molecular epidemiological analysis of Mycobacterium tuberculosis isolates from rural population of nationwide tuberculosis prevalence survey in Mongolia

open access: yesCentral Asian Journal of Medical Sciences
Objective: Mongolia is among the 30 high-burden countries for TB and DR-TB. Whole-genome sequencing (WGS) offers precise insights into TB transmission, strain diversity, and antimicrobial resistance (AMR), which are vital for TB control strategies.
Oyuntuya Tumenbayar   +9 more
doaj   +1 more source

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