Results 111 to 120 of about 4,993,363 (331)

Mycophenolic acid induces apoptosis of hepatic stellate cells in an in vitro model of HCV

Annals of Hepatology, 2015
Introduction. Hepatitis C virus (HCV) infection is an important risk factor for the development of liver fibrosis and progression to cirrhosis. Liver transplantation as terminal treatment option for liver disease requires life-long immunosuppression ...
Jan Best, Andreas Zahn, Anja Beilfuß, Svenja Sydor, Christian Fingas, Jan-Peter Sowa, Olympia Anastasiou, Vito Cicinnati, Guido Gerken, Ali Canbay, Lars P. Bechmann   +10 more
doaj  

Are Strong Bronsted Acids Necessarily Strong Lewis Acids? [PDF]

arXiv, 2006
The Broensted and Lowry acid base theory is based on the capacity of proton donation or acceptance (in the presence or absence of a solvent) whereas the Lewis acid base theory is based on the propensity of electron pair acceptance or donation. We explore through DFT calculation the obvious question whether these two theories are in conformity with each
arxiv  

Mouse versus Rat: Profound Differences in Meiotic Regulation at the Level of the Isolated Oocyte [PDF]

, 2011
Cumulus cell-enclosed oocytes (CEO), denuded oocytes (DO), or dissected follicles were obtained 44–48 hr after priming immature mice (20–23 days old) with 5 IU or immature rats (25–27 days old) with 12.5 IU of equine chorionic gonadotropin, and exposed ...
Biggers, Brannstrom, Chen, Chen, Cho, Dekel, Dekel, Dekel, Dekel, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Downs, Eppig, Fagbohun, Fagbohun, Han, Hubbard, LaRosa, LaRosa, Larsen, Magnusson, Makris, Masciarelli, Mouse Genome Sequencing Consortium, Mullins, Norris, Norris, Norris, Racowsky, Rat Genome Sequencing Project Consortium, Ratner, Ratner, Reizel, Richard, Romero, Schultz, Sela-Abramovich, Sela-Abramovich, Sela-Abramovich, Shitsukawa, Tornell, Tornell, Tornell, Tornell, Tornell, Tsafriri, Tsafriri, Vaccari, Vivarelli, Zeilmaker, Zhang, Zhang, Zhang, Zhao   +61 more
core   +2 more sources

The Factors of the Classification of Protein Amino Acids [PDF]

This paper is published in GLASNIK of Montenegrin Academy of Science and arts, 2000, 13, pp. 173-194, 2006
In this work it is shown that three pairs of the factors appear to be the key, i.e. main factors of a natural classification of protein (canonical) amino acids within the amino acid (genetic) code. First pair: the factors of the habit of an amino acid molecule (size and polarity).
arxiv  

Reduction of N-glycan profile variation by using capacitance probes for optimized process control [PDF]

, 2016
The glycan profile of therapeutic monoclonal antibodies frequently plays an important role in their biological function and pharmacokinetics. Therefore, improved control of the glycosylation profile of biopharmaceutical monoclonal antibodies has become ...
Bro, Christopher, Kristensen, Tom, Tollstrup, Anne, Wahlers, Michael, Zhang, An   +4 more
core   +1 more source

M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit [PDF]

, 2008
Myxoma virus (MYXV), a member of the Poxviridae family, is the agent responsible for myxomatosis, a fatal disease in the European rabbit (Oryctolagus cuniculus).
Bertagnoli, Stéphane, Blanié, Sophie, Camus-Bouclainville, Christelle, Delverdier, Maxence, Mortier, Jérémy   +4 more
core   +4 more sources

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

Electroanalytical overview: the sensing of the mycophenolate mofetil and mycophenolic acid

Analytical Methods
In this review, we explore the electroanalytical determination of mycophenolate mofetil and mycophenolic acid.
Crapnell, Robert D, Banks, Craig E
openaire   +3 more sources

Influence of Calcineurin Inhibitor and Sex on Mycophenolic Acid Pharmacokinetics and Adverse Effects Post–Renal Transplant

Journal of clinical pharmacology, 2019
Tacrolimus or cyclosporine is prescribed with mycophenolic acid posttransplant and contributes to interpatient variability in mycophenolic acid pharmacokinetics and response.
C. Meaney, P. Sudchada, J. Consiglio, G. Wilding, Louise M. Cooper, R. Venuto, K. Tornatore   +6 more
semanticscholar   +1 more source

Biotransformations of imbricatolic acid by Aspergillus niger and Rhizopus nigricans cultures [PDF]

, 2007
Guillermo Schmeda-Hirschmann and Carlos Aranda Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile. Jaime A. Rodríguez and Cristina Theoduloz. Depto.
Aranda, C., Kurina, M., Rodriguez, J., Schmeda-Hirschmann, G., Theoduloz, C.   +4 more
core   +2 more sources