Results 121 to 130 of about 4,993,363 (331)

Limited Sampling Strategy for the Estimation of Mycophenolic Acid and its Acyl Glucuronide Metabolite Area under the Concentration-Time Curve in Japanese Lung Transplant Recipients

Journal of Pharmacy & Pharmaceutical Sciences, 2019
Purpose: The dose of mycophenolate mofetil (MMF) used to prevent rejection after lung transplantation is often adjusted based on the 12-hour area under the concentration-time curve (AUC0-12) of mycophenolic acid (MPA).
Masaki Tanaka, Masafumi Kikuchi, Shinya Takasaki, Tensei Hirasawa, Kensuke Sigeta, Aoi Noda, Miki Akiba, Yasushi Matsuda, Hisashi Oishi, Tetsu Sado, Masafumi Noda, Yoshinori Okada, Nariyasu Mano, Hiroaki Yamaguchi   +13 more
doaj   +1 more source

Modeling of the formation of short-chain acids in propane flames [PDF]

arXiv, 2009
In order to better understand their potential formation in combustion systems, a detailed kinetic mechanism for the formation of short-chain monocarboxylic acids, formic (HCOOH), acetic (CH3COOH), propionic (C2H5COOH) and propenic (C2H3COOH)) acids, has been developed. Simulations of lean (equivalence ratios from 0.9 to 0.48) laminar premixed flames of
arxiv  

Discovery Of Copper Catalyst For New Chemical Polishing Acid On Superconducting Niobium [PDF]

arXiv, 2020
High field Q-slope (HFQS) seriously limits the high gradient performance of the buffered chemically polished (BCP) superconducting radio frequency (SRF) niobium cavities. The direct cause or mechanism is not yet fully understood. In our recent extensive data analysis, we concluded that the potential root cause could be nitrogen contamination on the ...
arxiv  

A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code [PDF]

, 2009
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis include formation in hydrothermal vents and delivery to Earth via meteorites.
arxiv   +1 more source

Population pharmacokinetics of mycophenolic acid in pediatric renal transplant patients using parametric and nonparametric approaches. [PDF]

, 2011
International audienceMycophenolic acid (MPA) is an immunosuppressive drug widely used in the prevention of acute rejection in pediatric renal transplant recipients and is characterized by a wide inter-individual variability in its pharmacokinetics.
Marquet, Pierre, Oellerich, M., Prémaud, Aurélie, Rousseau, Annick, Tönshoff, B., Urien, S., W Armstrong, V., Weber, Lt   +7 more
core   +3 more sources

PHARMACOECONOMIC ANALYSIS OF EVEROLIMUS IMMUNOSUPRESSIVE THERAPY AFTER RENAL TRANSPLANTATION

Фармакоэкономика, 2015
Objective: to calculate cost difference between two approaches for immunosuppressive therapy after renal transplantation: everolimus plus reducedexposure cyclosporine and mycophenolic acid plus standard-exposure cyclosporine. Methods.
M. V. Avxentyeva, N. A. Avxentyev, M. Yu. Frolov, E. V. Derkach   +3 more
doaj   +1 more source

Sensitive Rapid Fluorescence Polarization Immunoassay for Free Mycophenolic Acid Determination in Human Serum and Plasma.

Analytical Chemistry, 2018
In this Article, we describe a fluorescence polarization immunoassay (FPIA) using a new label-near-infrared fluorescent dye. The developed FPIA method was optimized for the rapid analysis of free mycophenolic acid (MPA) in plasma of transplanted patients.
Bettina Glahn-Martínez, E. Benito-Peña, F. Salis, Ana B. Descalzo, G. Orellana, M. Moreno-Bondi   +5 more
semanticscholar   +1 more source

European Guideline (EuroGuiDerm) on atopic eczema: Living update

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The updated guideline includes a new evidence‐based recommendation for the IL‐13 inhibitor lebrikizumab. In addition, the Janus kinase inhibitors baricitinib and abrocitinib, which were initially only approved for adult patients, are now also recommended for children from the age of 2 and adolescents from the age of 12, respectively.
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara‐Pinton, S. Christen‐Zaech, M. Deleuran, M. Dittmann, N. Fosse, K. Gáspár, L. A. A. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, S. Holland, C. G. Mortz, A. Nast, U. Nygaard, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra‐Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, R. N. Werner, C. Flohr   +31 more
wiley   +1 more source

Effects of Inosine-5′-monophosphate Dehydrogenase (IMPDH/GuaB) Inhibitors on Borrelia burgdorferi Growth in Standard and Modified Culture Conditions

Microorganisms
Borrelia burgdorferi’s inosine-5′-monophosphate dehydrogenase (IMPDH, GuaB encoded by the guaB gene) is a potential therapeutic target. GuaB is necessary for B. burgdorferi replication in mammalian hosts but not in standard laboratory culture conditions.
Eric L. Siegel, Connor Rich, Sanchana Saravanan, Patrick Pearson, Guang Xu, Stephen M. Rich   +5 more
doaj   +1 more source

Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense

Marine Drugs, 2018
Mycophenolic acid (MPA) is a potent inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitor for immunosuppressive chemotherapy. Most importantly, as the 2-morpholinoethyl ester prodrug of MPA, mycophenolate mofetil (MMF) is a well-known ...
Qing Zhang, Beiye Yang, Fengli Li, Mengting Liu, Shuang-jun Lin, Jianping Wang, Yongbo Xue, Hucheng Zhu, Weiguang Sun, Zhengxi Hu, Yonghui Zhang   +10 more
semanticscholar   +1 more source