Results 151 to 160 of about 4,993,363 (331)
Estudo da relação entre o polimorfismo c.98T>C do gene UGT1A9 e níveis plasmáticos de ácido micofenólico em pacientes transplantados renais [PDF]
, 2015 After the proceeding of a transplant, it is of huge concem the use of all therapeutic resource available in order to prevent graft rejection. The incidence and severity of acute rejection have been reduced along time due to the development of new ...
Ruschel, Lizania Rodrigues
core
Acta Physiologica, Volume 241, Issue 5, May 2025.ABSTRACT Aim Calcineurin inhibitors (CNIs) have revolutionized transplant medicine, improving allograft survival but posing challenges like calcineurin inhibitor‐induced nephrotoxicity (CNT). Acute CNT, often dose‐dependent, leads to vasoconstriction and acute kidney injury, with treatment focusing on CNI exposure reduction.
Carla M. Hansen +4 more
wiley +1 more source
Molecules, 2018 5-LOX inhibition is among the desired characteristics of anti-inflammatory drugs, while 15-LOX has also been considered as a drug target. Similarity in inhibition behavior between soybean LOX-1 and human 5-LOX has been observed and soybean LOX (sLOX ...
E. Tsolaki +4 more
semanticscholar +1 more source
Large scale analysis of routine dose adjustments of mycophenolate mofetil based on global exposure in renal transplant patients. [PDF]
, 2011 International audienceBACKGROUND: : We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment based on mycophenolic acid interdose area under the curve (AUC) in renal transplant patients.
Debord, Jean +5 more
core +2 more sources
British Journal of Clinical Pharmacology, Volume 91, Issue 5, Page 1396-1408, May 2025.Abstract Aims Mycophenolic acid (MPA), the active component of enteric‐coated mycophenolate sodium (EC‐MPS), exhibits highly variable pharmacokinetics. Only a few population pharmacokinetic (popPK) models and Bayesian estimators (MAP‐BE) exist for estimating MPA AUC and all in renal transplantation.
Yeleen Fromage +6 more
wiley +1 more source
The Effect of Tacrolimus and Mycophenolic Acid on CD14+ Monocyte Activation and Function
PLoS ONE, 2017 Monocytes and macrophages play key roles in many disease states, including cellular and humoral rejection after solid organ transplantation (SOT). To suppress alloimmunity after SOT, immunosuppressive drug therapy is necessary.
Nynke M Kannegieter +6 more
semanticscholar +1 more source
1-Alpha, 25-dihydroxyvitamin D3 alters the pharmacokinetics of mycophenolic acid in renal transplant recipients by regulating two extrahepatic UDP-glucuronosyltransferases 1A8 and 1A10 [PDF]
, 2016 Mycophenolic acid (MPA) is an important immunosuppressant broadly used in renal transplantation. However, the large inter-patient variability in mycophenolic acid (MPA) pharmacokinetics (PK) limits its use.
Cooper, Bruce R. +13 more
core +1 more source
Journal of the European Academy of Dermatology and Venereology, EarlyView.
Khaled Ezzedine +10 more
wiley +1 more source
New Diagnosis of Lupus Nephritis in the Third Trimester—A Case Report
Nephrology, Volume 30, Issue 5, May 2025.ABSTRACT New‐onset lupus nephritis (LN) poses a diagnostic and management challenge during pregnancy. This is more pertinent in the indigenous population, where the prevalence is higher, and the clinical phenotype tends to be more severe. We report the case of a 30‐year‐old G3P2 indigenous female, living in remote Queensland, with a late presentation ...
Umesha Pathmanathan +6 more
wiley +1 more source