Results 181 to 190 of about 14,175 (232)

Biosynthesis of mycophenolic acid

Journal of the Chemical Society, Perkin Transactions 1, 1972
Incorporation experiments with labelled potential biosynthetic intermediates suggest that the methyl group at C-4 of the phthalide system in mycophenolic acid is introduced at the tetraketide stage. This then gives way to the aromatic system, which is further oxidised to 5,7-dihydroxy-4-methylphthalide.
L. Canonica, W. Kroszczynski, B. M. Ranzi, B. Rindone, E. Santaniello, C. Scolastico   +5 more
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Mycophenolic acid in psoriasis

British Journal of Dermatology, 2006
Mycophenolic acid (MPA) is a fermentation product of a penicillium mould which has shown antitumour acitivity in certain animal models. It blocks nucleic acid synthesis by interfering with the interconversions of inosine monophosphate (IMP), xanthine monophosphate (XMP) and guanine monophosphate (GMP) thereby inhibiting growth and/or replication of ...
Charles J. McDonald, Alicja Rudnicka, Stanley Spatz   +2 more
openaire   +3 more sources

Mycophenolic Acid for Psoriasis

Archives of Dermatology, 1977
Mycophenolic acid is an antimetabolite used experimentally for the treatment of psoriasis. Thirty-eight patients were treated with mycophenolic acid. A double-blind, placebo-controlled study demonstrated the efficacy of mycophenolic acid (P less than .01).
William S. Lynch, Henry H. Roenigk
openaire   +3 more sources

The biosynthesis of mycophenolic acid

Journal of the Chemical Society D: Chemical Communications, 1970
The biosynthesis of mycophenolic acid (I) in Penicillium brevi-compactum occurs through introduction and a subsequent partial removal of a farnesyl side-chain into 5,7-dihydroxy-4-methylphthalide (II); the methyl group of (II) is introduced prior to the formation of the aromatic system.
W. Kroszczynski, B. M. Ranzi, B. Rindone, Carlo Scolastico, L. Canonica   +4 more
openaire   +2 more sources

Mycophenolate Acid vs Mycophenolate Mofetil Therapy

Transplantation Proceedings, 2010
Mycophenolate mofetil (MMF) is included in the basic immunosuppression regimen in heart transplantation (HTx). Classically, the mycophenolic acid (MPA) concentration has not been considered to provide clinical information.To perform a comparative analysis of MMF dosage and MPA concentration and their effect on post-HTx renal function.Sixty patients ...
Luis Martínez-Dolz, L. Almenar, Manuel Portolés, Esther Rosello, Miguel Rivera, Antonio Salvador, Ignacio Sánchez-Lázaro   +6 more
openaire   +2 more sources

Mycophenolic Acid for Lymphomatoid Papulosis

Journal of Cutaneous Medicine and Surgery, 2013
Background: Lymphomatoid papulosis is a rare CD30+ lymphoproliferative T-cell disorder with limited effective treatments. Objective: We describe the case of a 50-year-old woman diagnosed with lymphomatoid papulosis who was unable to access phototherapy and who failed to clear while on systemic treatment with methotrexate.
Trevor Champagne, Scott Walsh
openaire   +3 more sources

Analogues of mycophenolic acid

Bioorganic Chemistry, 1975
Abstract Analogues of mycophenolic acid were produced by cultures of Penicillium brevi-compactum fed, respectively, with 4,6-dihydroxycoumaran-3-one, 5,7-dihydroxyindan-1-one, and 2,4-dihydroxyacetophenone.
R. Craveri, Bruno Rindone, F. Aragozzini, C. Scolastico, M.G. Beretta, P. Toppino   +5 more
openaire   +2 more sources

Mycophenolic acid in marketed cheeses

Food and Cosmetics Toxicology, 1979
Analysis of a total of 100 samples of blue-moulded cheese showed that 38 contained mycophenolic acid, three at levels higher than 10 ppm. This contamination is particularly frequent in some types of cheese, and is due to the use, in their manufacture, of those Penicillum roqueforti strains that produce a high yield of mycophenolic acid in vitro.
J. Lafont, M.G. Siriwardana, I. Combemale, P. Lafont   +3 more
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Blood Distribution of Mycophenolic Acid

Therapeutic Drug Monitoring, 1994
RS-61443 (RS) a morpholinoethyl ester of mycophenolic acid (MPA), can be considered a prodrug, as immunosuppressive activity is expressed only after hydrolysis to MPA upon absorption. Little is known about the blood distribution of MPA; such information would have an impact on the medium used for analysis of the drug in clinical trials.
Loralie J. Langman, Randall W. Yatscoff, Donald F. LeGatt   +2 more
openaire   +3 more sources

Antifibrotic actions of mycophenolic acid

Clinical Transplantation, 2006
Abstract:  Mycophenolic acid (MPA) is a highly selective, non‐competitive and reversible inhibitor of the inosine monophosphate dehydrogenase (IMPDH), the rate‐limiting enzyme in the de novo biosynthesis of guanosine nucleotides. Mycophenolate mofetil (MMF, the ester prodrug of MPA) strongly inhibits both T‐ and B‐lymphocyte proliferation and has now ...
Jörg Beimler, Vedat Schwenger, Arianeb Mehrabi, Martin Zeier, Christian Morath, Walter Muranyi, Jan Schmidt   +6 more
openaire   +3 more sources