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Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. [PDF]
, 1993 Duquesnoy, RJ +6 more
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Heterologous production of immunosuppressant mycophenolic acid in Aspergillus nidulans [PDF]
, 2016 Aasted, Freja +6 more
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Mycophenolate Acid vs Mycophenolate Mofetil Therapy
Transplantation Proceedings, 2010Mycophenolate mofetil (MMF) is included in the basic immunosuppression regimen in heart transplantation (HTx). Classically, the mycophenolic acid (MPA) concentration has not been considered to provide clinical information.To perform a comparative analysis of MMF dosage and MPA concentration and their effect on post-HTx renal function.Sixty patients ...
I J, Sánchez-Lázaro +6 more
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Biosynthesis of mycophenolic acid
Journal of the Chemical Society, Perkin Transactions 1, 1972Incorporation experiments with labelled potential biosynthetic intermediates suggest that the methyl group at C-4 of the phthalide system in mycophenolic acid is introduced at the tetraketide stage. This then gives way to the aromatic system, which is further oxidised to 5,7-dihydroxy-4-methylphthalide.
L. Canonica +5 more
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Mycophenolic acid in psoriasis
British Journal of Dermatology, 2006Mycophenolic acid (MPA) is a fermentation product of a penicillium mould which has shown antitumour acitivity in certain animal models. It blocks nucleic acid synthesis by interfering with the interconversions of inosine monophosphate (IMP), xanthine monophosphate (XMP) and guanine monophosphate (GMP) thereby inhibiting growth and/or replication of ...
S, Spatz, A, Rudnicka, C J, McDonald
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