Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
IMMUNOSUPPRESSIVE EFFECT OF MYCOPHENOLIC ACID
The Journal of Antibiotics, 1969 The immune response to sheep red blood cells of the mice treated with mycophenolic acid was studied from both humoral and cellular aspects. Mycophenolic acid showed markedly immunosuppressive effect on the antibody formation when mice were treated with daily doses of more than 60mg/kg for 5 consecutive days starting on the day of antigen injection ...
Seikichi Suzuki, Akiko Mitsui
openaire +4 more sources
Successful treatment of HIV‐associated lupus‐like glomerulonephritis with mycophenolic acid
Clinical Case Reports, 2020 HIV‐associated lupus‐like glomerulonephritis is an uncommon but well‐described entity. Treatment has traditionally focused on control of HIV viremia with some using adjuvant steroids.
Mark Tiong +3 more
doaj +1 more source
Inhibition of nucleotide biosynthesis potentiates the antifungal activity of amphotericin B. [PDF]
PLoS ONE, 2014 The polyene antifungal agent Amphotericin B exhibits potent and broad spectrum fungicidal activity. However, high nephrotoxicity can hinder its administration in resource poor settings.
Dithi Banerjee +2 more
doaj +1 more source
Identification of IMP Dehydrogenase as a Potential Target for Anti-Mpox Virus Agents
Microbiology Spectrum, 2023 Mpox virus (formerly monkeypox virus [MPXV]) is a neglected zoonotic pathogen that caused a worldwide outbreak in May 2022. Given the lack of an established therapy, the development of an anti-MPXV strategy is of vital importance.
Takayuki Hishiki +20 more
doaj +1 more source
The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2 [PDF]
Journal of the European Ceramic Society, Volume 32, Issue 1, 2012,
Pages 235-244, 2013 The agglomeration, electrokinetic properties and electrophoretic deposition behaviour of aqueous suspensions of ZrO2 with carboxylic acid additives were studied in comparison with conventional pH adjustment. It was found that citric acid imparted negative zeta-potential values and electrosteric stabilisation to particles in suspensions at all pH levels.
arxiv +1 more source
First-principles molecular structure search with a genetic algorithm
, 2015 The identification of low-energy conformers for a given molecule is a fundamental problem in computational chemistry and cheminformatics. We assess here a conformer search that employs a genetic algorithm for sampling the low-energy segment of the ...
Baldauf, Carsten +2 more
core +2 more sources
Mycophenolic Acid Metabolites Acyl-Glucuronide and Glucoside Affect the Occurrence of Infectious Complications and Bone Marrow Dysfunction in Liver Transplant Recipients. [PDF]
, 2015 BACKGROUND Mycophenolic acid (MPA) prodrugs are anti-proliferative immunosuppressive agents commonly used after organ transplantation. Although they are generally well tolerated by patients, adverse effects may occur.
Borowiec, Agnieszka +8 more
core +1 more source
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To evaluate the trends, safety, and feasibility of a trial of labor after cesarean (TOLAC) among kidney and liver transplant recipients. Methods This was a retrospective cohort study using the Transplant Pregnancy Registry International.
Anjali Walia +7 more
wiley +1 more source
Nature's Starships. I. Observed Abundances and Relative Frequencies of Amino Acids in Meteorites [PDF]
, 2014 The class of meteorites called carbonaceous chondrites are examples of material from the solar system which have been relatively unchanged from the time of their initial formation. These meteorites have been classified according to the temperatures and physical conditions of their parent planetesimals.
arxiv +1 more source