Results 81 to 90 of about 4,993,363 (331)

Therapeutic drug monitoring of tacrolimus and mycophenolic acid in outpatient renal transplant recipients using a volumetric dried blood spot sampling device

British Journal of Clinical Pharmacology, 2018
Tacrolimus and mycophenolic acid dosing after renal transplantation is individualized through therapeutic drug monitoring (TDM). Home‐based dried blood spot (DBS) sampling has the potential to replace conventional TDM sampling at the clinic.
Tom C. Zwart, Sumit R M Gokoel, P. V. D. van der Boog, J. D. de Fijter, D. Kweekel, J. Swen, H. Guchelaar, D. Moes   +7 more
semanticscholar   +1 more source

Recent Advancements in Microfluidic Biosensors for Clinical Applications

iLABMED, EarlyView.
The combination of low‐consumption microfluidic chips and high‐sensitivity biosensors enables rapid and accurate detection of complex target analytes. This integrated system holds significant potential for applications in disease diagnosis, health monitoring, and treatment management.
Haiyan Wang, Wenjuan Wu
wiley   +1 more source

Mycophenolic acid and 6-mercaptopurine both inhibit B-cell proliferation in granulomatosis with polyangiitis patients, whereas only mycophenolic acid inhibits B-cell IL-6 production.

PLoS ONE, 2020
Granulomatosis with polyangiitis (GPA) is an autoimmune disease affecting mainly small blood vessels. B-cells are important in the GPA pathogenesis as precursors of autoantibody-producing cells but likely also contribute (auto)antibody-independently ...
Anouk von Borstel, Wayel H Abdulahad, Gerjan Dekkema, Abraham Rutgers, Coen A Stegeman, Johanna Veldman, Peter Heeringa, Jan Stephan Sanders   +7 more
doaj   +1 more source

Meteoritic Abundances of Fatty Acids and Potential Reaction Pathways in Planetesimals [PDF]

Icarus, 2019, 319, 685-700, 2018
The origin of fatty acids on the prebiotic Earth is important as they likely formed the encapsulating membranes of the first protocells. Carbon-rich meteorites (i.e., carbonaceous chondrites) such as Murchison and Tagish Lake are well known to contain these molecules, and their delivery to the early planet by intense early meteorite bombardments ...
arxiv   +1 more source

Mycophenolic Acid and Other Metabolites of Penicillium brevicompactum [PDF]

, 1971
The major part of this thesis describes studies on the biosynthesis of the benzoylated drimane sesquiterpene pebrolide and on mycophenolic acid.
Baxter, Robert Laurence
core  

Immunosuppressant prescription pattern and trend in kidney transplantation: A multicenter study in Korea. [PDF]

PLoS ONE, 2017
The actual prescription pattern of immunosuppressive agents in kidney transplantation is unclear.We investigated the pattern and trend of immunosuppressive treatment for kidney transplant patients in South Korea.
Ji-Yeun Chang, Jihyun Yu, Byung Ha Chung, Jaeseok Yang, Sung-Joo Kim, Chan-Duck Kim, Sang-Ho Lee, Jong Soo Lee, Joong Kyung Kim, Cheol Woong Jung, Chang Kwon Oh, Chul Woo Yang   +11 more
doaj   +1 more source

Effectiveness of Dupilumab and Omalizumab in Bullous Pemphigoid: A Nationwide Retrospective Cohort Study

The Journal of Dermatology, EarlyView.
ABSTRACT Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. In the difficult‐to‐treat BP or if standard therapies are contraindicated, the use of biologics may be also considered although there is no strong evidence supporting their use.
Gianluca Avallone, Carlo Alberto Maronese, Martina Zussino, Simona Muratori, Silvia Mariel Ferrucci, Pietro Quaglino, Elisabetta Manni, Marco Romanelli, Clara De Simone, Caterina Foti, Luigi Gargiulo, Vincenzo Maione, Piergiacomo Calzavara‐Pinton, Federico Bardazzi, Bianca Maria Piraccini, Emiliano Antiga, Giulia Rech, Riccardo Balestri, Pamela Vezzoli, Paolo Sena, Maria Esposito, Maria Concetta Fargnoli, Davide Termini, Luca Valtellini, Rosanna Rita Satta, Camilla Vassallo, Alessia Provini, Giovanni Di Zenzo, Anna Campanati, Marzia Caproni, Emanuele Cozzani, Simone Ribero, Angelo Valerio Marzano, DUO—DUpilumab and Omalizumab in Bullous Pemphigoid Study Group, Armando Pisapia, Giovanni Genovese, Federica Gelato, Luca Mastorino, Cristian Fidanzi, Luca Rapparini, Domenico Simeoli, Elena Marra, Gennaro Marco Falco, Paolo Romita, Riccardo Viola, Mauro Grandolfo, Luciano Ibba, Luisa Sarno, Roberto Maglie, Valentina Ruffo di Calabria, Aurora Parodi   +50 more
wiley   +1 more source

Simultaneous determination of twelve mycotoxins in edible oil, soy sauce and bean sauce by PRiME HLB solid phase extraction combined with HPLC-Orbitrap HRMS

Frontiers in Nutrition, 2022
A solid phase extraction-high-performance liquid chromatography-tandem Orbitrap high resolution mass spectrometry (HPLC-Orbitrap HRMS) method was established for the determination of 12 mycotoxins (ochratoxin A, ochratoxin B, aflatoxin B1, aflatoxin B2 ...
Donghui Luo, Donghui Luo, Jingjing Guan, Hao Dong, Jin Chen, Ming Liang, Chunxia Zhou, Yanping Xian, Xiaofei Xu   +8 more
doaj   +1 more source

Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation [PDF]

, 1994
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after ...
Fujisaki, S, Irish, W, Miyazawa, H, Murase, N, Starzl, TE, Tanabe, M, Todo, S   +6 more
core   +1 more source

Safety concerns of paternal drug exposure on fertility, pregnancy and offspring: An analysis based on the FDA adverse event reporting system

Andrology, EarlyView.
Abstract Background Growing evidence indicates that paternal condition significantly influences pregnancy outcomes and offspring health. However, assessing the safety of paternal drug exposure via randomized controlled trials poses ethical challenges, and relevant clinical studies consume a lot of resources to evaluate only a few drugs.
Yanbin Zeng, Wanlong Lin, Wei Zhuang
wiley   +1 more source