Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
French Prospective Clinical Evaluation of the Aptima Mycoplasma genitalium CE-IVD Assay and Macrolide Resistance Detection Using Three Distinct Assays [PDF]
, 2017 Chloé Le Roy +3 more
openalex +1 more source
Estudos de inibição de proteínas tirosina fosfatases de Mycobacterium tuberculosis e Yersinia enterocolitica, e caracterização de uma proteína serina/treonina fosfatase de Mycoplasma synoviae [PDF]
, 2014 A fosforilação reversível de proteínas mediada por proteínas cinases e fosfatases tem uma função reguladora central em muitos processos celulares em eucariotos e procariotos. Especialmente, proteínas tirosina fosfatases (PTPs), que constituem uma família
Menegatti, Angela Camila Orbem
core
Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae
, 2013 Five Mycoplasma strains from wild Caprinae were analyzed: four from Alpine ibex (Capra ibex) which died at the Berlin Zoo between 1993 and 1994, one from a Rocky Mountain goat collected in the USA prior to 1987.
Jores, J. +20 more
core +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
SOME STUDIES ON THE MICROBIOLOGICAL CAUSES AND BIOCHEMICAL CHANGES IN MASTITIC MILK WITH EMPHASIS ON FUNGI AND MYCOPLASMA [PDF]
, 1997 R. Ragheb +3 more
openalex +1 more source
Economic Consequences of Biological Variation: The Case of Mycoplasma in Swine Herds
We present an economic decision support model, based on a Bayesian network, for Mycoplasma infection in slaughter swine production. The model describes the various risk factors for Mycoplasma infection and their interactions.
Otto, Lars
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source