This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Profound immune suppression and exhaustion characterize refractory mycoplasma pneumoniae pneumonia in children. [PDF]
Ma X, Wu Y, He F, Yao H, Cao L, Zhu C.
europepmc +1 more source
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Uncommon Presentation of <i>Mycoplasma pneumoniae</i>: Rash and Mucositis Manifestation. [PDF]
Kanat A +3 more
europepmc +1 more source
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Age<b>,</b> C-reactive protein, and hospital stay Are associated with switching from azithromycin to doxycycline in pediatric macrolide-resistant <i>Mycoplasma pneumoniae</i> pneumonia. [PDF]
Zhang M +6 more
europepmc +1 more source
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Severe Mycoplasma pneumoniae Pneumonia During the 2023-2024 European Re-Emergence: Why Severity Does Not Predict Macrolide Resistance. [PDF]
Perugini E +7 more
europepmc +1 more source
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao +12 more
wiley +1 more source
Long-term burden, trends, and inequality of lower respiratory infections attributable to <i>Mycoplasma pneumoniae</i> among children and adolescents in low- and middle-income countries, 1990-2023: a Global Burden of Disease Study 2023 analysis. [PDF]
Zhang Y, Zhang L, Zhang L, Huang Y.
europepmc +1 more source

