Results 201 to 210 of about 147,742 (269)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

<i>Mycoplasma bovis</i> infection alters small extracellular vesicle cargo derived from bovine endometrial epithelial cells cultured in static bioreactors. [PDF]

Front Microbiol
Pratt JT, Lake AVR, Maes E, Thomas A, Hefer C, Mitchell MD, Heiser A, Ross MA.   +7 more
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Macrolide resistance and risk factors for refractory Mycoplasma pneumoniae pneumonia in pediatric patients from Wuhu, China: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Jiang T, Xiang X, Li H, Yang Z, Wang Z, Wang J, Xiao M.   +6 more
europepmc   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Role of the <i>Mycoplasma bovis deoC</i> gene in nucleoside catabolism and host cell survival. [PDF]

Appl Environ Microbiol
Geng S, Elahee Doomun SN, Hondrogiannis J, De Souza DP, Kanci Condello A, Browning GF, Klose SM, Tivendale KA, Wawegama NK.   +8 more
europepmc   +1 more source

Mycoplasma pneumoniae

Folia Pharmacologica Japonica, 2013
openaire   +3 more sources

Hemoglobinuria associated with Candidatus Mycoplasma Haemobos in a primiparous Holstein cow in Turkey: a case report. [PDF]

Vet Res Commun
Emlik F, Şakar HF, Türk S, Şahin ÖF, Erol U, Altay K, Coşkun A.   +6 more
europepmc   +1 more source

Investigation of Some Clinicopathologic Alterations in Cats Infected With Mycoplasma haemofelis and Candidatus Mycoplasma haemominutum in Mashhad, Iran: An Observational Cross-Sectional Study. [PDF]

Vet Med Sci
Shahtahmasbi E, Valavi E, Razmi GR, Zaeemi M.   +3 more
europepmc   +1 more source

Nonlinear age-season dynamics and macrolide resistance of Mycoplasma pneumoniae: a large pediatric cohort study during the post-pandemic resurgence. [PDF]

BMC Infect Dis
Chen H, Fan Y, Zhang X, Huang Y.
europepmc   +1 more source