Results 61 to 70 of about 182,089 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Genome Sequence of Mycoplasma feriruminatoris sp. nov., a Fast-Growing Mycoplasma Species [PDF]

, 2013
Members of the “Mycoplasma mycoides cluster” represent important livestock pathogens worldwide. We report the genome sequence of Mycoplasma feriruminatoris sp.
Vilei, Edy M., Frey, Joachim, Jores, Joerg, Drabek, Elliott, Giglio, Michelle, Nadendla, Suvarna, Santana-Cruz, Ivette, Fischer, Anne   +7 more
core   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hemotrophic mycoplasmas induce programmed cell death in red blood cells [PDF]

, 2011
Hemotrophic mycoplasmas (HM) are uncultivable bacteria found on and in the red blood cells (RBCs). The main clinical sign of HM infections is the hemolytic anemia. However, anemia-inducing pathogenesis has not been totally clarified. In this work we used
Groebel, K, Ritzmann, Mathias, Hoelzle, Katharina, Kilchling, T, Mathias Ritzmann, Ritzmann, M, Felder, Kathrin M., Hoelzle, K, Ludwig E. Hoelzle, Schiele, D, Katharina Hoelzle, Heinritzi, K, Daniela Schiele, Kilchling, Tim, Kathrin M. Felder, Tim Kilchling, Karl Heinritzi, Felder, K M, Katrin Groebel, Heinritzi, Karl, Groebel, Katrin, Schiele, Daniela, Hoelzle, Ludwig E, Hoelzle, Ludwig E.   +23 more
core   +1 more source

Mycoplasma pneumoniae infections, 11 countries in Europe and Israel, 2011 to 2016 [PDF]

, 2020
Background: Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia, with large epidemics previously described to occur every 4 to 7 years. Aim: To better understand the diagnostic methods used to detect M.
Nir-Paz, Ran,, Georgakopoulou, Theano, Anestad, Gabriel,, Chalker, Victoria J., MacKenzie, Colin Rae,, Spiller, O Brad, Kese, Darja, Yandle, Zoe,, McMenamin, Jim, Moran, Joanne,, Bebear, Cecile,, Maltezou, Helena C.,, Froes, Filipe,, Dumke, Roger,, Vestrheim, Didrik F., Marques, Diogo Pereira,, Burns, Karen,, Giske, Christian,, Koliou, Maria,, Pereyre, Sabine,, Socan, Maja,, Michael-Gayego, Ayelet, Beeton, Michael L, Uldum, Soren A., Anestad, Gabriel, Reynolds, Arlene, Cano Portero, Rosa,, Cano-Portero, Rosa, Chalker, Victoria J.,, Froes, Filipe, Blystad, Hans,, Gullsby, Karolina, Havlickova, Martina, Havlickova, Martina,, Chlamydia Infections (ESGMAC) Mycoplasma pneumoniae subgroup, Emborg, Hanne-Dorthe, Zhang, Xu-Sheng, Fenech, Tanya Melillo,, Kese, Darja,, Reynolds, Arlene,, Loens, Katherine, Fenech, Tanya Melillo, Zhang, Xu-Sheng,, Beeton, Michael L.,, Emborg, Hanne-Dorthe,, Ieven, Margareta, Michael-Gayego, Ayelet,, Spiller, O. Brad,, The Escmid Study Group For Mycoplasma And Chlamydia Infections Esgmac Mycoplasma Pneumoniae Subgroup,, Koliou, Maria, Pereyre, Sabine, Ieven, Margaretha, Bossuyt, Nathalie, Moses, Allon E., Voldstedlund, Marianne,, Banou, Kirkira,, Suarez Rodriguez, Berta, Lagrou, Katrien,, Georgakopoulou, Theano,, Spiller, O. Brad, Vestrheim, Didrik F.,, Ieven, Margareta,, McMenamin, Jim,, Socan, Maja, Maltezou, Helena C., ESCMID Study Group for Mycoplasma, Balla, Eszter, Uldum, Søren A, Moran, Joanne, Burns, Karen, Kyncl, Jan,, Santos Sanz, Sara,, Ternhag, Anders,, Lagrou, Katrien, Ternhag, Anders, Uldum, Soren A.,, Giske, Christian, Moses, Allon E.,, Banou, Kirkira, Uldum, Søren A., Dumke, Roger, Voldstedlund, Marianne, Bossuyt, Nathalie,, Bébéar, Cécile, Petridou, Evangelina, MacKenzie, Colin Rae, Nir-Paz, Ran, Connell, Jeff, Cano Portero, Rosa, Santos Sanz, Sara, Gullsby, Karolina,, Mitis, George,, Wisell, Karin Tegmark, The Escmid Study Group For Mycoplasma And Chlamydia Infections Esgmac Mycoplasma Pneumoniae Subgroup, -, Suarez Rodriguez, Berta,, Petridou, Evangelina,, Loens, Katherine,, Blystad, Hans, Yandle, Zoe, Marques, Diogo Pereira, Chalker, Victoria J, Balla, Eszter,, Kyncl, Jan, Connell, Jeff,, Beeton, Michael L., Wisell, Karin Tegmark,, ESCMID Study Group for Mycoplasma and Chlamydia Infections (ESGMAC) Mycoplasma pneumoniae sub-group, Mitis, George   +107 more
core   +1 more source

Mapping phosphoproteins in Mycoplasma genitalium and Mycoplasma pneumoniae [PDF]

BMC Microbiology, 2007
Abstract Background Little is known regarding the extent or targets of phosphorylation in mycoplasmas, yet in many other bacterial species phosphorylation is known to play an important role in signaling and regulation of cellular processes. To determine the prevalence of phosphorylation in mycoplasmas, we examined the
Hutchison Clyde A, Su Hsun-Cheng, Giddings Morgan C   +2 more
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Absence of Mycoplasma Contamination in the Anthrax Vaccine

Emerging Infectious Diseases, 2002
Mycoplasma contamination of the licensed anthrax vaccine administered to military personnel has been suggested as a possible cause of Persian Gulf illness.
Mary Kate Hart, Richard A. Del Giudice, George W. Korch   +2 more
doaj   +1 more source

Клінічні особливості реактивних артритів у дітей

Актуальні проблеми сучасної медицини, 2020
. Reactive arthritis includes inflammatory non-purulent diseases of the joints that develop within 2-4 weeks after intestinal or urogenital infection due to immune disorders.
Nataliya Panko, Iryna Lebets, Natalia Shevchenko, Oksana Tsiura, Hanna Shlieienkova, Antonina Butenko   +5 more
doaj   +1 more source

Mycoplasmas and arthritis [PDF]

Arthritis & Rheumatism, 1970
AbstractThe role of mycoplasmal infection in human beings with rheumatoid arthritis and Reiter's syndrome was studied by three methods. First, specimens of synovial fluid were inoculated directly onto mycoplasmal media, and after appropriate incubation, examined for growth of mycoplasmal colonies.
openaire   +2 more sources