Results 71 to 80 of about 195,622 (313)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mycoplasma feriruminatoris sp. nov., a fast growing Mycoplasma species isolated from wild Caprinae [PDF]

, 2013
Five Mycoplasma strains from wild Caprinae were analyzed: four from Alpine ibex (Capra ibex) which died at the Berlin Zoo between 1993 and 1994, one from a Rocky Mountain goat collected in the USA prior to 1987.
Jores, J., Liebler-Tenorio, Elisabeth M, Liebler-Tenorio, E.M., Sirand-Pugnet, P., Heller, M., Heller, Martin, Liebler-Tenorio, Elisabeth M., Santana-Cruz, I., Santana-Cruz, Ivette, Fischer, Anne, Thomann, A., Sirand-Pugnet, Pascal, Jores, Joerg, Schnee, Christiane, Frey, Joachim, Fischer, A., Frey, J., Sirand-Pugnet, Pascal,, Thomann, Andreas, Schnee, C., Sirand-Pugnet, Pascal, P.   +20 more
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Multi-center evaluation of one commercial and 12 in-house real-time PCR assays for detection of Mycoplasma pneumoniae

, 2017
: Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches.
Katherine Loens, Nir-Paz, Ran,, Benitez, AJ, Birgit Henrich, Gullsby, K, Ursi, Dominique,, Pereyre, S, Nir-Paz, R, Kese, Darja, Jonas M. Winchell, Michael-Gayego, A, Moses, AE, Bebear, Cecile,, Petersen, Randi F.,, Bebear, Cecile, Dumke, Roger,, Maaskant, Jolanda, Unger, Wendy W. J., Hidalgo-Grass, C, Carlos Hidalgo-Grass, van Rossum, Annemarie M. C.,, Roger Dumke, Sabine Pereyre, Jolanda Maaskant, Pas, Suzan D.,, Winchell, Jonas M., Pereyre, Sabine,, Chalker, V, van Rossum, Annemarie, Hidalgo-Grass, Carlos, Petersen, RF, Henrich, Birgit,, Michael-Gayego, Ayelet, Uldum, Soren A., Alvaro J. Benitez, Uldum, Soren A.,, Randi F. Petersen, Benitez, Alvaro J., Søren A. Uldum, van Rossum, Annemarie M. C., Moses, Allon E.,, Annemarie M.C. van Rossum, Dumke, Roger, Wendy W.J. Unger, Unger, Wendy, Rosenblatt, Meike,, Hoogenboezem, Theo,, Ran Nir-Paz, Gullsby, Karolina, Rosenblatt, Meike, Karolina Gullsby, Uldum, SA, Winchell, JM, Kese, D, Ursi, Dominique, Rosenblatt, M, Winchell, Jonas M.,, Suzan D. Pas, Pas, Suzan, Theo Hoogenboezem, Ayelet Michael-Gayego, Hoogenboezem, Thomas, Benitez, Alvaro J.,, Kese, Darja,, Nir-Paz, Ran, Loens, Katherine, Petersen, Randi F., Meike Rosenblatt, Loens, K, Chalker, Victoria,, Bebear, C, Gullsby, Karolina,, Henrich, B, Hidalgo-Grass, Carlos,, Maaskant, Jolanda,, Allon E. Moses, Ursi, D, Pas, Suzan D., Michael-Gayego, Ayelet,, Hoogenboezem, Theo, Loens, Katherine,, Pereyre, Sabine, Henrich, Birgit, Moses, Allon E., Victoria Chalker, Dumke, R, Darja Kese, Dominique Ursi, Unger, Wendy W. J.,, Cecile Bebear, Chalker, Victoria   +90 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Mycoplasmas and arthritis [PDF]

Arthritis & Rheumatism, 1970
AbstractThe role of mycoplasmal infection in human beings with rheumatoid arthritis and Reiter's syndrome was studied by three methods. First, specimens of synovial fluid were inoculated directly onto mycoplasmal media, and after appropriate incubation, examined for growth of mycoplasmal colonies.
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source