Results 91 to 100 of about 204,618 (368)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pneumonia bacteriana adquirida na comunidade: avaliação clínico-epidemiológica e padronização de métodos moleculares para detecção de Mycoplasma pneumoniae, Haemophilus influenzae e Streptococcus pneumoniae [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo ...
Machado, Lais Del Prá Netto
core  

Diagnosis of Mycoplasma from Starlings Lungs

, 2019
Starlings have tremendous economic and environmental impacts because they can spread pathogens to livestock and poultry. These birds act as mechanical and biological carriers for different types of pathogens from and to their original habitat.
A.M. Al-Aalim, Mohammad A. Hamad, Aamer Y.H. Alchalaby   +2 more
core   +1 more source

Frequency of Mycoplasma genitalium, Mycoplasma hominis and Ureaplasma urealyticum among Females Patients Attending Gynecology and Obstetrics Clinics at Ain Shams University Hospital

, 2020
Mycoplasmas and Ureaplasmas inhabit the genitourinary tract of sexually active males and females. Mycoplasma genitalium infection as well as Ureaplasma urealyticum are related to many reproductive health problems such as cervicitis, urethritis and ...
Mona A. Khattab, Shimaa A. Abdel Salam, Malames M. Faisal   +2 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Emerging Antibiotic Resistance in Mycoplasma Microorganisms, Designing Effective and Novel Drugs / Therapeutic Targets: Current Knowledge and Futuristic Prospects

Journal of Pure and Applied Microbiology, 2019
Emerging antibiotic resistance among mycoplasma microorganisms is of major concern in present times as they cause various diseases in both animals and humans. Mycoplasmoses, infections caused by mycoplasma microorganisms have become common in recent past
Mohd. Iqbal Yatoo, Oveas Raffiq Parray, Riyaz Ahmed Bhat, Muheet, Arumugam Gopalakrishnan, Archana Saxena, Sandip Chakraborty, Ruchi Tiwari, Sandip Kumar Khurana, Shoor Vir Singh, Kuldeep Dhama   +10 more
doaj   +1 more source

Proteínas extracelulares de Mycoplasma synoviae e estudos proteômicos das associações micorrízicas arbusculares [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2012A presente tese de doutorado trata de estudos feitos através de uma abordagem proteômica em duas ...
Couto, Manuel Sebastián Rebollo
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Easy and rapid diagnosis of Mycoplasma pneumonia: is it possible?

The Egyptian Journal of Bronchology, 2019
Background Atypical pneumonia (AP) with its different pathogens comprises a reasonable ratio of community-acquired pneumonia. Mycoplasma pneumoniae (M.
Reham M. Elkolaly, Maii A. Shams Eldeen
doaj   +1 more source