Results 81 to 90 of about 204,618 (368)

Multiple Origins and Specific Evolution of CRISPR/Cas9 Systems in Minimal Bacteria (Mollicutes)

Frontiers in Microbiology, 2019
CRISPR/Cas systems provide adaptive defense mechanisms against invading nucleic acids in prokaryotes. Because of its interest as a genetic tool, the Type II CRISPR/Cas9 system from Streptococcus pyogenes has been extensively studied. It includes the Cas9
Thomas Ipoutcha, Thomas Ipoutcha, Iason Tsarmpopoulos, Iason Tsarmpopoulos, Vincent Talenton, Vincent Talenton, Christine Gaspin, Annick Moisan, Caray A. Walker, Joe Brownlie, Alain Blanchard, Alain Blanchard, Patricia Thebault, Pascal Sirand-Pugnet, Pascal Sirand-Pugnet   +14 more
doaj   +1 more source

Análise proteômica de proteínas citoplasmáticas de Mycoplasma synoviae [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biotecnologia, Florianópolis, 2010O Mycoplasma synoviae é um dos mais importantes patógenos de aves domésticas em todo o mundo ...
Menegatti, Angela Camila Orbem
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Detection of Mycoplasma capricolum capricolum from goats of Qom province, Iran

Archives of Razi Institute, 2015
Mycoplasma capricolum subsp capricolum (Mcc) is one of the etiological agents of contagious agalactia(C.A) in goats which can cause significant economic losses. The aim of this study was to detect Mcc from goats of Qom province in Iran.
Pourbakhsh, S.A., Abtin, A.R., Ashtari, A., Bayatzadeh, M.A., Barani, S.M., , Asli, E.   +5 more
doaj  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Detection of Mycoplasma bovis in Pneumonic Calves

, 2019
Mycoplasma bovis is a major pathogen in respiratory diseases of calves and cause an excessive economic loses. The current study was a goal to diagnoses bovine Mycoplasma and chiefly M.
Mohammad T. Jaber Mayahi, Zahraa M. AL-Jumaa, Mohammad A. Hamad, Ammar M. Al-Aalim   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Multi-center evaluation of one commercial and 12 in-house real-time PCR assays for detection of Mycoplasma pneumoniae

, 2017
: Detection of Mycoplasma pneumoniae by real-time PCR is not yet standardized across laboratories. We have implemented a standardization protocol to compare the performance of thirteen commercial and in-house approaches.
Katherine Loens, Nir-Paz, Ran,, Benitez, AJ, Birgit Henrich, Gullsby, K, Ursi, Dominique,, Pereyre, S, Nir-Paz, R, Kese, Darja, Jonas M. Winchell, Michael-Gayego, A, Moses, AE, Bebear, Cecile,, Petersen, Randi F.,, Bebear, Cecile, Dumke, Roger,, Maaskant, Jolanda, Unger, Wendy W. J., Hidalgo-Grass, C, Carlos Hidalgo-Grass, van Rossum, Annemarie M. C.,, Roger Dumke, Sabine Pereyre, Jolanda Maaskant, Pas, Suzan D.,, Winchell, Jonas M., Pereyre, Sabine,, Chalker, V, van Rossum, Annemarie, Hidalgo-Grass, Carlos, Petersen, RF, Henrich, Birgit,, Michael-Gayego, Ayelet, Uldum, Soren A., Alvaro J. Benitez, Uldum, Soren A.,, Randi F. Petersen, Benitez, Alvaro J., Søren A. Uldum, van Rossum, Annemarie M. C., Moses, Allon E.,, Annemarie M.C. van Rossum, Dumke, Roger, Wendy W.J. Unger, Unger, Wendy, Rosenblatt, Meike,, Hoogenboezem, Theo,, Ran Nir-Paz, Gullsby, Karolina, Rosenblatt, Meike, Karolina Gullsby, Uldum, SA, Winchell, JM, Kese, D, Ursi, Dominique, Rosenblatt, M, Winchell, Jonas M.,, Suzan D. Pas, Pas, Suzan, Theo Hoogenboezem, Ayelet Michael-Gayego, Hoogenboezem, Thomas, Benitez, Alvaro J.,, Kese, Darja,, Nir-Paz, Ran, Loens, Katherine, Petersen, Randi F., Meike Rosenblatt, Loens, K, Chalker, Victoria,, Bebear, C, Gullsby, Karolina,, Henrich, B, Hidalgo-Grass, Carlos,, Maaskant, Jolanda,, Allon E. Moses, Ursi, D, Pas, Suzan D., Michael-Gayego, Ayelet,, Hoogenboezem, Theo, Loens, Katherine,, Pereyre, Sabine, Henrich, Birgit, Moses, Allon E., Victoria Chalker, Dumke, R, Darja Kese, Dominique Ursi, Unger, Wendy W. J.,, Cecile Bebear, Chalker, Victoria   +90 more
core   +1 more source