Results 81 to 90 of about 182,089 (314)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Differential innate immune responses induced by Mycoplasma hyopneumoniae and Mycoplasma hyorhinis in various types of antigen presenting cells. [PDF]

, 2020
Mycoplasma (M.) hyopneumoniae is the etiological agent of enzootic pneumonia in pigs and is closely related to M. hyorhinis, which can be isolated from the healthy mucosal surfaces of the upper respiratory tract. In rare cases it can also cause arthritis
Trueb, Bettina S., Summerfield, Artur, Kuhnert, Peter, Auray, Gaël, Braun, Roman Othmar   +4 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Pneumonia bacteriana adquirida na comunidade: avaliação clínico-epidemiológica e padronização de métodos moleculares para detecção de Mycoplasma pneumoniae, Haemophilus influenzae e Streptococcus pneumoniae [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2015.A pneumonia pode ser causada por diversos microrganismos e classificada de forma abrangente, havendo ...
Machado, Lais Del Prá Netto
core  

Detection of Mycoplasma bovis in Pneumonic Calves

, 2019
Mycoplasma bovis is a major pathogen in respiratory diseases of calves and cause an excessive economic loses. The current study was a goal to diagnoses bovine Mycoplasma and chiefly M.
Mohammad T. Jaber Mayahi, Zahraa M. AL-Jumaa, Mohammad A. Hamad, Ammar M. Al-Aalim   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Diagnosis of Mycoplasma from Starlings Lungs

, 2019
Starlings have tremendous economic and environmental impacts because they can spread pathogens to livestock and poultry. These birds act as mechanical and biological carriers for different types of pathogens from and to their original habitat.
A.M. Al-Aalim, Mohammad A. Hamad, Aamer Y.H. Alchalaby   +2 more
core   +1 more source

Biochemical and serological characterization of Mycoplasma from bovine clinical mastitis in southwest and northern Nigeria

, 2010
The primary objective of this study was to isolate and characterize the mycoplasma species present in clinical cases of mastitic cows in Southwest and Northern Nigeria and to determine the prevalence of mycoplasma mastitis in dairy cows. Two hundred milk
Adetosoye, A. I., Amosun, E. A., Ajuwape, A. T. P.   +2 more
core   +1 more source

Emerging Antibiotic Resistance in Mycoplasma Microorganisms, Designing Effective and Novel Drugs / Therapeutic Targets: Current Knowledge and Futuristic Prospects

Journal of Pure and Applied Microbiology, 2019
Emerging antibiotic resistance among mycoplasma microorganisms is of major concern in present times as they cause various diseases in both animals and humans. Mycoplasmoses, infections caused by mycoplasma microorganisms have become common in recent past
Mohd. Iqbal Yatoo, Oveas Raffiq Parray, Riyaz Ahmed Bhat, Muheet, Arumugam Gopalakrishnan, Archana Saxena, Sandip Chakraborty, Ruchi Tiwari, Sandip Kumar Khurana, Shoor Vir Singh, Kuldeep Dhama   +10 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source