Results 91 to 100 of about 89,623 (336)

Guidelines for the use of cell lines in biomedical research [PDF]

, 2014
Cell-line misidentification and contamination with microorganisms, such as mycoplasma, together with instability, both genetic and phenotypic, are among the problems that continue to affect cell culture.
Capes-Davis, A., Davis, J.M., Downward, J., Freshney, R.I., Geraghty, R.J., Knezevic, I., Lovell-Badge, R., Masters, J.R.W., Meredith, J., Stacey, G.N., Thraves, P., Vias, M.   +11 more
core   +2 more sources

EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation

Advanced Science, EarlyView.
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi, Ping Yang, Huaijin Qiao, Jinchen He, Bin Song, Hao Bai, Fengdi Jiang, Yining Zhang, Qian Li, Tao Yan, Wenlin Tu, Daojiang Yu, Shuyu Zhang   +12 more
wiley   +1 more source

The Role of Lipoproteins in Mycoplasma-Mediated Immunomodulation

Frontiers in Microbiology, 2018
Mycoplasma infections, such as walking pneumonia or pelvic inflammatory diseases, are a major threat to public health. Despite their relatively small physical and genomic size, mycoplasmas are known to elicit strong host immune responses, generally ...
Alexei Christodoulides, Neha Gupta, Vahe Yacoubian, Neil Maithel, Jordan Parker, Theodoros Kelesidis   +5 more
doaj   +1 more source

Bacterial urinary tract infections associated with transitional cell carcinoma in dogs. [PDF]

, 2015
BackgroundUrinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported.ObjectivesTo determine the frequency and bacterial agents associated with UTI
Budreckis, DM, Byrne, BA, Pollard, RE, Rebhun, RB, Rodriguez, CO, Skorupski, KA   +5 more
core   +1 more source

Histone Demethylase UTX Suppresses Tumor Cell Proliferation by Regulating Stress Granules

Advanced Science, EarlyView.
These findings indicate that cytoplasmic UTX forms puncta and co‐localizes in stress granules (SGs) upon various stresses. UTX TPR‐domain‐dependently and demethylase‐activity‐independently destabilize SGs by binding G3BP1, the SG hub protein, to disrupt SG network, thus affects tumorigenesis.
Xikai Liu, Xinran Liu, Mei Xue, Yushuo Xiao, Yuchen Chen, Rong Qiu, Di Wu, Yihao Zhou, Jiao Wang, Yan Yuan, Linwei Yu, Tianyi Shi, Yangkai Li, Hua Su, Hong Chen, Yong Liu, Kun Huang, Ling Zheng   +17 more
wiley   +1 more source

Associations between EP-like lesions and pleuritis and post trimming carcass weights of finishing pigs in England [PDF]

, 2017
Herd health slaughter checks regularly identify enzootic pneumonia-like (EP-like) lesions and pleuritis. The aim of this paper is to determine the associations between these lesions and post-trimming carcass weight.
Brewster, V R, Maiti, H C, Nevel, A, Tucker, A W   +3 more
core   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Mycoplasma suis infection in suckling pigs on a Belgian farm [PDF]

, 2008
Mycoplasma suis (formerly known as Eperythrozoon suis) is an epicellular bacterium that affects porcine red blood cells. M. suis infections occur worldwide and are associated with weakness and anemia in suckling and weaned pigs, and reproductive ...
De Busser, Emily Valerie, Haesebrouck, Freddy, Hoelzle, LE, Maes, Dominiek, Mateusen, Bart, Vicca, Jo   +5 more
core   +1 more source

Principles of appropriate antibiotic use for treatment of uncomplicated acute bronchitis: background. [PDF]

, 2001
The following principles of appropriate antibiotic use for adults with acute bronchitis apply to immunocompetent adults without complicating comorbid conditions, such as chronic lung or heart disease.
Bartlett, JG, Besser, RE, Centers for Disease Control and Prevention, Cooper, RJ, Gonzales, R, Hickner, JM, Hoffman, JR, Sande, MA   +7 more
core   +2 more sources

Structure and Antigenicity of Kaposi's Sarcoma‐Associated Herpesvirus Glycoprotein B

Advanced Science, EarlyView.
Kaposi's sarcoma‐associated herpesvirus (KSHV) causes severe cancers without effective treatments. This study presents an atomic model of KSHV's critical infection protein, gB, revealing a unique structure shared with related herpesviruses like Epstein‐Barr virus (EBV). The structural similarity highlights vulnerable targets for antibodies, guiding the
Xin‐Yan Fang, Cong Sun, Chu Xie, Bing‐Zhen Cheng, Zheng‐Zhou Lu, Ge‐Xin Zhao, Sen‐Fang Sui, Mu‐Sheng Zeng, Zheng Liu   +8 more
wiley   +1 more source