Results 91 to 100 of about 19,673 (227)

Multi‐omics profiling of chronic immune‐mediated skin diseases: SKINERGY protocol and strategic evaluation

Journal of the European Academy of Dermatology and Venereology, EarlyView.
The SKINERGY study will investigate six immune‐mediated inflammatory skin diseases through a nationwide collaboration across all Dutch university medical centres. Involving 720 patients and 120 healthy volunteers, it is aimed at generating a high‐quality dataset to identify biomarkers that enable personalized treatment strategies and improved disease ...
N. G. Koster, J. M. P. A. van den Reek, E. M. G. J. de Jong, S. van Beugen, A. I. M. van Laarhoven, I. Haeck, M. de Bruin‐Weller, M. L. Schuttelaar, B. Horvath, A. Gostyński, A. Knulst, M. H. Vermeer, L. Nguyen, L. Gerbens, P. Spuls, M. A. Middelkamp‐Hup, V. Exadaktylos, T. Niemeyer‐van der Kolk, A. R. Schrader, A. M. Sluijmers, J. Versteeg, B. W. M. Arents, I. van Ee, J. L. A. G. van der Zon, M. de Leeuw, T. de Leeuw, P. van den Broek, C. Berkhof, D. Vellinga, S. Weidinger, S. Dubrac, Y. Li, M. van Steensel, M. Marchetti‐Deschmann, M. Maurer, H. van der Zee, J. Damman, D. J. Hijnen, F. Wijk, M. M. B. Seyger, H. Röckmann, D. M. W. Balak, M. B. A. van Doorn, R. Rissmann, The Next Generation ImmunoDermatology (NGID) consortium, Rob Vreeken, Eva Cuypers, Boudewijn Lelieveldt, Abdoel El Ghalbzouri, Hanna Niehues, Ellen van den Bogaard, Tom Ederveen, Els van der Pool, Nanda Olde, Debra Trampe, Ellen Stijl‐’t Hart, Lisanne Wezendonk, Johan Westerhuis, Huma Shehwana, Joerg Schreiber, Jeremy Bost, Mie Bech Lukassen, Jimmy Bakker, Juliette Simons, Fauve van den Berge, Colin Spence, Elise Beljaards, Anastasiia Myronenko, Mariona Oliver   +68 more
wiley   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Treatment of pagetoid reticulosis with intensity modulated radiation therapy [PDF]

, 2014
Pagetoid reticulosis, also known as Woringer-Kolopp disease, is a rare variant of cutaneous T-cell lymphoma usually presenting as an isolated patch or plaque on the extremities.
Bradbury, Matthew, Cornelius, Lynn, Ferraro, Daniel, Gay, Hiram, Gru, Alejandro, Mount, Charles   +5 more
core   +1 more source

Plantar keratoderma of Sézary syndrome [PDF]

, 2017
Sézary syndrome is an extremely rare form of cutaneous T-cell lymphoma. It presents suddenly and is associated with a poor prognosis. Clinical recognition is crucial for the diagnostic process and initiation of appropriate treatment.
Fragkos, KC
core   +1 more source

Diagnostic concordance of dermatopathology and PCR in differentiating eczema from psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Distinguishing psoriasis from eczema is challenging due to overlapping clinical and histological features. This study shows substantial inter‐observer variability among dermatopathologists and demonstrates that a NOS2‐/CCL27‐based molecular test, including a fully automated platform, provides more accurate and reproducible diagnoses, particularly in ...
Andrea Schmitt, Susanne Proksch, Ludwig Gutzweiler, Sandra Roth, Marcella Engler, Cornelia S. L. Müller, Andreas Volz, Andreas W. Arnold, Monika Šedivcová, Adriana Bernklauova, Miroslav Dura, Denisa Kacerovska, Katja Technau‐Ihling, Christian Ihling, Christiane Rakozy, Wiebke Pruessmann, Thomas Leibing, Maria Isabel von Eichborn, Johannes Kern, Elisabeth Oms, Stefanie Eyerich, Kilian Eyerich, Helmut Laaff, Natalie Garzorz‐Stark, Kristin Technau‐Hafsi   +24 more
wiley   +1 more source

THE ROLE OF THE CD8+:CD3+ RATIO OF CELL DIFFERENTIATION MARKERS IN LYMPHOCYTIC INFILTRATES OF THE SKIN WITH MYCOSIS FUNGOIDES

Ukrainian Scientific Medical Youth Journal, 2016
Histological diagnosis of mycosis fungoides is complicated, particularly during the early clinical manifestations of skin disease where changes can be interpreted as a banal inflammation.
Hamade Luay Mustafa
doaj  

Cutaneous T‐cell lymphomas and dupilumab for atopic dermatitis: A systematic review and expert consensus

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Systematic review (51 studies; 547 patients) indicates dupilumab may unmask/worsen CTCL (mainly MF/SS). A French Delphi consensus recommends rigorous diagnostic workup, avoiding dupilumab in confirmed CTCL, discontinuing upon diagnosis, and favouring methotrexate or phototherapy.
Florent Amatore, Madeleine Neildez, Adèle de Masson, Maxime Battistella, Marie Tauber, Saskia Ingen‐Housz‐Oro, Catherine Droitcourt, Delphine Staumont‐Sallé, Marie Beylot‐Barry   +8 more
wiley   +1 more source

STAT5 induces miR-21 expression in cutaneous T cell lymphoma [PDF]

, 2016
In cutaneous T cell lymphomas (CTCL), miR-21 is aberrantly expressed in skin and peripheral blood and displays anti-apoptotic properties in malignant T cells. It is, however, unclear exactly which cells express miR-21 and what mechanisms regulate miR-21.
Blümel, Edda,, Bonefeld, Charlotte M.,, Fredholm, Simon,, Geisler, Carsten,, Gluud, Maria,, Hu, Tengpeng,, Iversen, Lars,, Joseph, Claudine,, Jæhger, Ditte,, Jønson, Lars,, Koralov, Sergei B.,, Krejsgaard, Thorbjørn,, Lindahl, Lise M.,, Litvinov, Ivan V.,, Lund University., Mongan, Nigel,, Nastasi, Claudia,, Nielsen, Boye Schnack,, Odum, Niels,, Persson, Jenny L.,, Petersen, David L.,, Ralfkiaer, Elisabeth,, Sasseville, Denis,, Sibbesen, Nina,, Wasik, Mariusz A.,, Willerslev-Olsen, Andreas,, Woetmann, Anders,   +26 more
core   +2 more sources

Apoptosis kinetics of purified and PBMC‐associated lymphocytes after photopheresis‐like 8‐methoxypsolaren/UVA treatment

Photochemistry and Photobiology, EarlyView.
Extracorporeal photopheresis (ECP) induces apoptosis in circulating immune cells, but its kinetics vary slightly depending on the cell type. We compared the progression of apoptosis in PBMCs versus highly purified T cells exposed to 8‐methoxypsoralen and ultraviolet A.
Carlos Agustin Villegas‐Valverde, Imilla Casado Hernandez, Yandy Marx Castillo‐Aleman, Gisela Maria Suarez‐Formigo, Amar Riaz, Antonio Alfonso Bencomo‐Hernandez, Yendry Ventura‐Carmenate   +6 more
wiley   +1 more source

Successful Treatment of Erythrodermic Mycosis Fungoides with Mogamulizumab Followed by Etoposide Monotherapy

Case Reports in Oncology, 2018
Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary
Taku Fujimura, Kayo Tanita, Yota Sato, Yumi Kambayashi, Sadanori Furudate, Akira Tsukada, Akira Hashimoto, Setsuya Aiba   +7 more
doaj   +1 more source