Results 71 to 80 of about 19,673 (227)

Staphylococcus aureus Augments Epithelial Skin Barrier Damage Through T Cell Activation in Cutaneous T Cell Lymphoma

Allergy, EarlyView.
Staphylococcus aureus, commonly colonising CTCL patients, augments skin barrier dysfunction. Staphylococcal enterotoxins induce T‐cell release of barrier‐repressing cytokines (IL‐4, IL‐13, IL‐22, OSM). Cytokine signalling drives JAK‐dependent downregulation of filaggrin and loricrin in keratinocytes. Antibiotic‐mediated eradication of S. aureus induces
Maria Gluud, Emil M. Pallesen, Ziao Zeng, Martin R. J. Namini, Chella Krishna Vadivel, Lise Mette Rahbek Gjerdrum, Lang Yan, Sana Ahmad, Lise M. Lindahl, Michael Bzorek, Maria R. Kamstrup, Saptaswa Dey, Sisse Rye Ostrowski, Erik Sørensen, Pia Rantakari, Charlotte Menne Bonefeld, Carsten Geisler, Anders Woetmann, Riitta Lahesmaa, Lars Iversen, Peter Wolf, Thomas Litman, Terkild B. Buus, Niels Ødum   +23 more
wiley   +1 more source

Mycosis fungoides and Sézary syndrome

healthbook TIMES. Oncology Hematology, 2021
Mycosis fungoides (MF) and Sézary syndrome (SS) are two subgroups of cutaneous T-cell lymphomas (CTCL), which belong to the extranodal non-Hodgkin lymphomas. These are rare diseases whose etiology is still not fully understood.
Ieva Saulite, Antonio Cozzio, Emmanuella Guenova   +2 more
doaj   +1 more source

Non‐Invasive Scalp Tape‐Strip RNA Sequencing Captures Disease Activity and Treatment‐Response Signatures in Alopecia Areata

Allergy, EarlyView.
Non‐invasive scalp tape‐strip RNA sequencing captures core immune and follicular molecular signatures in alopecia areata. Tape‐strip transcriptomic profiles reflect disease severity and treatment response to baricitinib, with concordance to scalp biopsy‐derived signatures.
Carmen Mochón‐Jiménez, Jesús Gay‐Mimbrera, Viviana Dávila‐Flores, Helen He, Jerry Zhou, Irene Rivera‐Ruiz, Pedro J. Gómez‐Arias, Juan de Luque‐Fernández, Benjamin Ungar, Emma Guttman‐Yassky, Juan Ruano   +10 more
wiley   +1 more source

Itch in patients with cutaneous T-cell lymphoma as a quality of life indicatorCapsule Summary

JAAD International, 2022
Background: Cutaneous T-cell lymphoma (CTCL) is a chronic and progressive disease that has a major impact on quality of life (QoL). Objectives: To describe the impact of the different stages of disease in patients with classical mycosis fungoides ...
Rosanne Ottevanger, MD, Sylvia van Beugen, MSc, PhD, Andrea W.M. Evers, MSc, PhD, Rein Willemze, MD, PhD, Maarten H. Vermeer, MD, PhD, Koen D. Quint, MD, PhD   +5 more
doaj   +1 more source

Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis [PDF]

, 2014
Mycosis fungoides (MF) often mimics the common chronic inflammatory skin diseases and is difficult to be diagnosed with certainty, partly because of the lack of well-characterized molecular markers.
Dutz, Jan P., Huang, Yuanshen, Jiang, Xiaoyan, Kupper, Thomas S., Litvinov, Ivan V., Sasseville, Denis, Su, Ming-Wan, Tu, Ping, Wang, Yang, Zhou, Youwen   +9 more
core   +1 more source

Diffuse CD30‐Positive Cutaneous Infiltrate in a Clinically Suspected Hidradenitis Suppurativa Lesion: Histopathologic and Diagnostic Challenges

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder affecting apocrine gland–bearing areas. We report a 38‐year‐old male with a lesion in the left axilla, initially clinically interpreted as HS and resistant to antibiotics.
R. Gervasi, G. L. Piazzetta, G. Soluri, C. Scigliano, C. Pelaia, V. Zuccalà, C. Gentile, N. Lobello, E. Allegra, E. Chiarella, N. Innaro   +10 more
wiley   +1 more source

Novel cell adhesion/migration pathways are predictive markers of HDAC inhibitor resistance in cutaneous T cell lymphoma [PDF]

, 2019
BACKGROUND: Treatment for Cutaneous T Cell Lymphoma (CTCL) is generally not curative. Therefore, selecting therapy that is effective and tolerable is critical to clinical decision-making. Histone deacetylase inhibitors (HDACi), epigenetic modifier drugs,
Andrews, Jared M, Carson, Kenneth R, Mehta-Shah, Neha, Musiek, Amy C, Payton, Jacqueline E, Schmidt, Jennifer A   +5 more
core   +2 more sources

Somatostatin receptor scintigraphy in cutaneous malignant lymphomas [PDF]

, 1996
Background: Lymphoid cells may express somatostatin receptors (SS-Rs) on their cell surface. Therefore radiolabeled somatostalin analogues may be used to visualize SS-R-positive lymphoid neoplasms in vivo.
Anker-Lugtenburg, P.J. (P.) van den, Heule, F. (Freerk), Joost, Th. (Theo) van, Krenning, E.P. (Eric), Löwenberg, B. (Bob), Oei, H.Y. (H.), Vanhagen, P.M. (P.)   +6 more
core   +1 more source

Elevated lymphoma risk in patients with chronic pruritus and chronic prurigo

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Chronic pruritus (CP) and chronic prurigo (CPG, including prurigo nodularis) are prevalent, debilitating diseases with diverse comorbidities, including malignancies. This retrospective cohort study evaluated the prevalence and risk of lymphoma in CP and CPG patients, including key risk factors, and sex‐ and ancestry ...
Svenja Royeck, Henning Olbrich, Steffen Koschmieder, Claudia Zeidler, Felix Witte, Konstantin Agelopoulos, Henning Wiegmann, Michael Storck, Johannes Benedict Oehm, Ralf J. Ludwig, Sonja Ständer   +10 more
wiley   +1 more source

Mycosis Fungoides and Associated Malignancies in a Dutch Nationwide Retrospective Cohort Study

Acta Dermato-Venereologica
The prognosis of patients with mycosis fungoides is variable. As the current literature is scarce and shows mixed results this study investigates the incidence of other primary malignancies in mycosis fungoides patients.
Rosanne Ottevanger, Esther Vermaas, Rein Willemze, Anne-Roos Schrader, Patty M. Jansen, Jelle J. Goeman, Hein Putter, Maarten H. Vermeer, Koen D. Quint   +8 more
doaj   +1 more source