Results 211 to 220 of about 201,896 (346)

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes

open access: yesGlia, Volume 73, Issue 6, Page 1203-1220, June 2025.
Main Points Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP‐deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in myelin sheath formation in vivo. ABSTRACT The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the ...
Vidya Ramesh   +15 more
wiley   +1 more source

Unexpected Remyelination in the Absence of Matrix Metalloproteinase 7

open access: yesGlia, Volume 73, Issue 6, Page 1288-1306, June 2025.
Main Points MMP7 is not essential for demyelination and remyelination in the cuprizone model. MMP7‐/‐ mice fibronectin aggregates do not accumulate in the remyelination phase. MMP7‐/‐ mice have lower levels of fibronectin and hyaluronan after chronic demyelination.
Rianne P. Gorter   +7 more
wiley   +1 more source

The INO80 Chromatin Remodeling Complex Regulates Histone H2A.Z Mobility and the G1‐S Transition in Oligodendrocyte Precursors

open access: yesGlia, Volume 73, Issue 6, Page 1307-1323, June 2025.
Main Points Inactivating the INO80 chromatin remodelling complex greatly extends the oligodendrocyte precursor (OP) cell cycle by prolonging G1. INO80 acts in OPs via histone H2A/H2A.Z exchange. INO80 binds the transcriptional regulator OLIG2 in OPs.
Jordan L. Wright   +4 more
wiley   +1 more source

Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 1: In vivo small‐animal imaging

open access: yesMagnetic Resonance in Medicine, Volume 93, Issue 6, Page 2507-2534, June 2025.
Abstract Small‐animal diffusion MRI (dMRI) has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. The steps from animal setup and monitoring, to acquisition, analysis, and interpretation are complex, with many decisions that may ultimately affect what questions ...
Ileana O. Jelescu   +56 more
wiley   +1 more source

Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2—Ex vivo imaging: Added value and acquisition

open access: yesMagnetic Resonance in Medicine, Volume 93, Issue 6, Page 2535-2560, June 2025.
Abstract The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non‐invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has several experimental advantages including higher SNR and spatial resolution compared to in vivo studies,
Kurt G. Schilling   +57 more
wiley   +1 more source

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