Results 231 to 240 of about 201,896 (346)

Deficiency of the Synaptic Adhesion Protein Leucine‐Rich Repeat Transmembrane Protein 4 Like 1 Affects Anxiety and Aggression in Zebrafish

open access: yesActa Physiologica, Volume 241, Issue 5, May 2025.
ABSTRACT Aim Leucine‐rich repeat transmembrane proteins (LRRTMs) are synaptic adhesion proteins that regulate synapse development and function. They interact transsynaptically with presynaptic binding partners to promote presynaptic differentiation. Polymorphisms of LRRTM4, one of the four members of this protein family, have been linked to multiple ...
Eva Tatzl   +7 more
wiley   +1 more source

Myosin II has distinct functions in PNS and CNS myelin sheath formation [PDF]

open access: hybrid, 2008
Haibo Wang   +4 more
openalex   +1 more source

The Pathobiology of Cerebrovascular Lesions in CADASIL Small Vessel Disease

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
ABSTRACT Cerebral small vessel disease (cSVD) is a significant global health issue, accounting for approximately 25% of ischemic strokes and 20% of all dementia cases. CADASIL, the most common monogenic form of cSVD, is caused by stereotyped mutations in the NOTCH3 receptor that alter the number of cysteine residues in its extracellular domain ...
Anne Joutel
wiley   +1 more source

Absence of 2-Hydroxylated Sphingolipids Is Compatible with Normal Neural Development But Causes Late-Onset Axon and Myelin Sheath Degeneration [PDF]

open access: hybrid, 2008
Inge Zöller   +6 more
openalex   +1 more source

Subcortical plaques and inflammation reflect cortical and meningeal pathologies in progressive multiple sclerosis

open access: yesBrain Pathology, Volume 35, Issue 3, May 2025.
In progressive MS, mixed active plaques and perivascular inflammation in the sub/juxtacortical white matter correlate with similar (albeit fainter) pathologies in the cortical parenchyma Abstract It remains elusive whether lesions and inflammation in the sub/juxtacortical white matter reflect cortical and/or meningeal pathologies.
Betül Okutan   +10 more
wiley   +1 more source

Adult Ceramide Synthase 2 (CERS2)-deficient Mice Exhibit Myelin Sheath Defects, Cerebellar Degeneration, and Hepatocarcinomas [PDF]

open access: hybrid, 2009
Silke Imgrund   +8 more
openalex   +1 more source

Long‐term fasting induces a remodelling of fatty acid composition in erythrocyte membranes

open access: yesEuropean Journal of Clinical Investigation, Volume 55, Issue 5, May 2025.
Abstract Introduction Long‐term fasting (LF) activates an adaptative response to switch metabolic fuels from food glucose to lipids stored in adipose tissues. The increase in free fatty acid (FFA) oxidation during fasting triggers health benefits. We questioned if the changes in lipid metabolism during LF could affect lipids in cell membranes in humans.
Katharina Gewecke   +5 more
wiley   +1 more source

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