Results 231 to 240 of about 48,603 (346)

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han   +10 more
wiley   +1 more source

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel

open access: yesAdvanced Science, Volume 12, Issue 21, June 5, 2025.
An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu   +12 more
wiley   +1 more source

White Matter Microstructure Alterations in Older Adults With Dyslipidemia Associated With Cognitive and Locomotor Dysfunction Evaluated Using Neurite Orientation Dispersion and Density Imaging

open access: yesBrain and Behavior, Volume 15, Issue 6, June 2025.
This study used NODDI to identify white matter microstructure alterations in older adults with dyslipidemia, revealing significantly reduced neurite density in several brain regions. These reductions were linked to declines in cognitive and motor functions, suggesting that NODDI may serve as a biomarker for dyslipidemia‐related axonal degeneration ...
Zaimire Mahemuti   +12 more
wiley   +1 more source

COVID‐19‐Associated Cytotoxic Lesions of the Corpus Callosum in Chinese Patients: A Retrospective Study

open access: yesBrain and Behavior, Volume 15, Issue 6, June 2025.
We report the clinical characteristics, radiological features, and changes in inflammatory markers throughout the entire course of illness in eight patients with COVID‐19‐associated CLOCCs. The neurological symptoms or signs in these patients included altered consciousness, headache, cognitive impairment, ataxia, dysarthria, pyramidal signs, and visual
Chenyi Wan   +6 more
wiley   +1 more source

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