Engineering the Future of Restorative Clinical Peripheral Nerve Surgery
Advanced Healthcare Materials, Volume 14, Issue 20, August 8, 2025.What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell +5 more
wiley +1 more source
Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness [PDF]
, 2001 Gregory A. Elder +2 more
openalex +1 more source
Nano‐Anesthetics Regulate Neuro‐Immune Interaction for Treating Neuropathic Pain
Advanced Science, Volume 12, Issue 29, August 7, 2025.Ce‐UiO‐66‐Bupivacaine (CUB) demonstrates triple therapeutic innovation: 1) Sustained analgesia with ROS scavenging synergistically resolves neuropathic pain; 2) Microglia/astrocyte polarization switch reprograms the pro‐regenerative immune microenvironment; 3) CGRP‐TSP‐1 axis activation couples inflammation suppression to axon regeneration, defining a ...
Yue Wang +9 more
wiley +1 more source
ATP-Binding Cassette Transporter ABC2/ABCA2 in the Rat Brain: A Novel Mammalian Lysosome-Associated Membrane Protein and a Specific Marker for Oligodendrocytes But Not for Myelin Sheaths [PDF]
, 2001 Chengji J. Zhou +7 more
openalex +1 more source
Clinical Case Reports, Volume 13, Issue 8, August 2025.ABSTRACT Ectopic ACTH secretion‐related Cushing's syndrome may manifest as a rapid onset of hypercortisolism, elevated urinary free cortisol (UFC) and blood ACTH concentrations, and hypokalemia. However, for patients whose primary lesions are difficult to remove, bilateral adrenalectomy is the recommended treatment method according to guidelines. Here,
Fang Sun +6 more
wiley +1 more source
Oligodendrocytes assist in the maintenance of sodium channel clusters independent of the myelin sheath [PDF]
, 2004 Jeffrey L. Dupree +6 more
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Food Science &Nutrition, Volume 13, Issue 8, August 2025.The positive influence of berberine on the nervous system can be attributed to its diverse effects on multiple targets. The effects of berberine include its antioxidant, anti‐apoptotic, anti‐necroptotic, and anti‐inflammatory properties, as well as its ability to induce autophagy.
Xiaolan Wang +5 more
wiley +1 more source
White matter intercompartmental water exchange rates determined from detailed modeling of the myelin sheath. [PDF]
Magn Reson Med, 2019 van Gelderen P, Duyn JH.
europepmc +1 more source
Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide
Glia, Volume 73, Issue 8, Page 1692-1706, August 2025.Main Points Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel peptide that promotes OL myelin formation. ABSTRACT In the central nervous system, oligodendrocytes (OLs) form myelin sheaths that accomplish the ...
Binri Sasaki +14 more
wiley +1 more source
Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.ABSTRACT Background Sarcopenia is defined by the age‐related loss of muscle mass and function, with an impaired regenerative capacity of satellite cells (SCs). Despite their recognized importance in muscle regeneration, human model‐based studies on SCs in sarcopenia are still lacking, limiting our understanding of their role in age‐related muscle loss.
Seongjun Park +14 more
wiley +1 more source