Results 251 to 260 of about 201,896 (346)

R‐Ras1 and R‐Ras2 regulate mature oligodendrocyte subpopulations

open access: yesGlia, Volume 73, Issue 4, Page 701-719, April 2025.
Main Points R‐Ras1 and R‐Ras2 are differentially expressed in mature oligodendrocytes subpopulations MOL1, MOL2 and MOL5/6. Lack of R‐Ras1 and R‐Ras2 produces an imbalance in mature oligodendrocyte subpopulation proportions. Abstract In the mammalian central nervous system, axonal myelination, executed by mature oligodendrocytes (MOLs), enables rapid ...
Berta Alcover‐Sanchez   +10 more
wiley   +1 more source

Modulation of OPC Mitochondrial Function by Inhibiting USP30 Promotes Their Differentiation

open access: yesGlia, Volume 73, Issue 4, Page 773-787, April 2025.
Main Points Mitochondrial changes occur during OPC differentiation and myelination. USP30 knockout promotes OPC differentiation and myelination in vitro. USP30 knockout OPCs and OLs exhibit differences in metabolism. ABSTRACT Multiple lines of evidence indicate that mitochondrial dysfunction occurs in demyelinating diseases, such as multiple sclerosis (
Allison L. Soung   +10 more
wiley   +1 more source

Post-Synaptic Density Proteins in Oligodendrocytes are Required for Activity-Dependent Myelin Sheath Growth

open access: green
Mary‐amélie Masson   +3 more
openalex   +1 more source

Axonal Selectivity of Myelination by Single Oligodendrocytes Established During Development in Mouse Cerebellar White Matter

open access: yesGlia, Volume 73, Issue 4, Page 873-886, April 2025.
Main Points Nearly half of OLs preferentially myelinate specific types of axons in the cerebellar white matter of adult mice. Early and later differentiated oligodendrocytes dominantly myelinate Purkinje cell and non‐Purkinje cell axons, respectively.
Batpurev Battulga   +4 more
wiley   +1 more source

Low‐Intensity Focused Ultrasound Ameliorates Cisplatin‐Induced Cognitive Impairment by Attenuating Hippocampal Neuroinflammation and Enhancing Synaptic Plasticity in Rats

open access: yesiRADIOLOGY, Volume 3, Issue 2, Page 152-167, April 2025.
The study evaluates the application of low‐intensity focused ultrasound (LIFUS) in alleviating cisplatin‐induced cognitive impairment in rats and explores the associated neural mechanisms. Through behavioral assessments and 9.4‐T small animal magnetic resonance imaging, results show that LIFUS improved cognitive function in rats, with significant ...
Xiaowei Han   +10 more
wiley   +1 more source

Crucial role of microglia-mediated myelin sheath damage in vascular dementia: antecedents and consequences

open access: gold
Qi Shao   +8 more
openalex   +1 more source

Age‐Stratified Treg Responses During Viral Infections of the Central Nervous System: A Literature Review

open access: yesJournal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Regulatory T cells (Tregs) play a vital role in limiting inflammation and resolving the immune response after a viral infection. Within the central nervous system (CNS), Tregs are especially important for the protection of neurons, which have limited regenerative capacity, and the preservation of myelin sheaths, which support neuronal function
Vivek R. Singh, Lauren A. O'Donnell
wiley   +1 more source

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